公开(公告)号：US06872846B2

公开(公告)日：2005-03-29

申请号：US10399516

申请日：2001-11-13

申请人： Shinya Nagano ,  Hiroshi Shimojitosho

发明人： Shinya Nagano ,  Hiroshi Shimojitosho

IPC分类号： C07C67/08 ,  C07B49/00 ,  C07C33/05 ,  C07C45/68 ,  C07C67/14 ,  C07C69/03 ,  C07C69/54 ,  C07C69/74

CPC分类号： C07C67/14 ,  C07C2602/42 ,  C07C2603/68 ,  C07C2603/74 ,  C07C69/54

摘要： The production process of the present invention comprises a step of allowing a carboxylic acid derivative represented by the formula (1): wherein ring Z is a monocyclic or polycyclic non-aromatic or aromatic ring, and R1 is a halogen atom or a group represented by the formula (2): —OR  (2) wherein R is a hydrogen atom or a hydrocarbon group, to react with an organometallic compound represented by the formula (3): R2-M  (3) wherein R2 is a hydrocarbon group, and M is a metallic atom which may have a ligand, or the formula (4): -MgY  (4) wherein Y is a halogen atom, and a carboxylic acid halide represented by the formula (5): wherein R3 is a hydrocarbon group or a heterocyclic group, and X is a halogen atom, to yield the tertiary alcohol ester represented by the formula (6): wherein Z, R2 and R3 have the same meanings as defined above. According to the present invention, a tertiary alcohol compound having a tertiary carbon combined with a ring group can be easily and efficiently produced from carboxylic acid derivative which is comparatively cheap and readily available.

摘要翻译： 本发明的制备方法包括使式（1）表示的羧酸衍生物：其中环Z为单环或多环非芳族或芳香环，R 1为卤素原子或 由式（2）表示的基团：其中R是氢原子或烃基，与式（3）表示的有机金属化合物反应：其中R 2是烃基，M是金属原子 其可以具有配体，或式（4）：其中Y是卤素原子，和由式（5）表示的羧酸卤化物：其中R 3是烃基或杂环基，X是 卤素原子，得到由式（6）表示的叔醇酯：其中Z，R 2和R 3具有与上述相同的含义。根据本发明，具有式 结合环基的叔碳可以从羧酸衍生物容易且有效地制备 这是比较便宜和容易获得的。