公开(公告)号：US11198898B2

公开(公告)日：2021-12-14

申请号：US16131798

申请日：2018-09-14

Applicant: CORNELL UNIVERSITY

Inventor： Jeremy Baskin ,  Timothy Bumpus ,  Dongjun Liang

IPC: C12Q1/42 ,  C07C233/60 ,  C07C33/05 ,  C07C43/196 ,  C07C235/08 ,  C07D321/12 ,  C07D313/18

Abstract: A method for detecting phospholipase D (PLD) activity in a cell, comprising: (i) stimulating endogenous PLD in said cell for said PLD to catalyze a transphosphatidylation reaction between phosphatidylcholine or a derivative thereof and an exogenous functionalized alcohol to form a phosphatidyl alcohol, wherein the functionalized alcohol possesses a first functional group that can react with and form a bond to a functionalized detectable label having a second functional group reactive with the first functional group, and said phosphatidyl alcohol contains said first functional group in available form; (ii) reacting said phosphatidyl alcohol with said functionalized detectable label under conditions where said functionalized detectable label reacts, via its second functional group, with the first functional group to form a linkage between said detectable label and said phosphatidyl alcohol so as to form a labeled phosphatidyl alcohol containing said detectable label; and (iii) detecting said labeled phosphatidyl alcohol.

公开(公告)号：US20130012422A1

公开(公告)日：2013-01-10

申请号：US13616766

申请日：2012-09-14

Applicant: Johan SMETS ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

Inventor： Johan SMETS ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

IPC: A61K8/34 ,  C11D3/50 ,  A61Q13/00 ,  C07C33/05

CPC classification number: C11D3/50 ,  A61K8/732 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C33/05 ,  C07C33/14 ,  C07C49/203 ,  C07C49/213 ,  C07C49/217 ,  C07C49/225 ,  C07C49/255 ,  C07C49/293 ,  C07C49/557 ,  C07C49/792 ,  C07C49/794 ,  C07C57/03 ,  C07C69/007 ,  C07C255/07 ,  C07C255/33 ,  C07C2601/04 ,  C07C2601/16 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0061 ,  C11B9/0065

Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Abstract translation: 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 本文公开的这种香料原料和组合物，包括递送系统，扩展了香水社区的选择，因为这样的香料原料可以提供特性的变化，并且这样的组合物可提供所需的气味分布。

公开(公告)号：US5047575A

公开(公告)日：1991-09-10

申请号：US258132

申请日：1988-10-14

Applicant: Guy Solladie ,  Serge Forestier ,  Gerard Lang

Inventor： Guy Solladie ,  Serge Forestier ,  Gerard Lang

IPC: A61K31/045 ,  A61K8/00 ,  A61K8/36 ,  A61K8/37 ,  A61K8/58 ,  A61K31/075 ,  A61K31/16 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/695 ,  A61P11/00 ,  A61P17/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07C27/00 ,  C07C29/14 ,  C07C29/147 ,  C07C29/38 ,  C07C31/137 ,  C07C33/05 ,  C07C33/12 ,  C07C33/14 ,  C07C41/00 ,  C07C43/162 ,  C07C43/168 ,  C07C45/27 ,  C07C45/29 ,  C07C47/225 ,  C07C49/557 ,  C07C57/26 ,  C07C67/00 ,  C07C69/587 ,  C07C69/608 ,  C07C233/10 ,  C07C255/31 ,  C07D263/12 ,  C07D309/12 ,  C07F7/18

CPC classification number: A61K8/36 ,  A61K8/37 ,  A61Q19/00 ,  A61Q7/00 ,  C07C33/12 ,  C07C45/27 ,  C07C45/298 ,  C07C47/225 ,  C07C57/26 ,  C07F7/1856 ,  A61Q19/008 ,  A61Q19/08

Abstract: Compounds, and a process for their preparation, have the formula ##STR1## or corresponding salts thereof wherein R represents a group of the formula ##STR2## wherein R.sub.1 represents oxazolinyl, --C.tbd.N, --CH.sub.2 OR.sub.2 or ##STR3## These compounds in the form of pharmaceutical or cosmetic compositions are useful for the treatment of keratinization disorders.

Abstract translation: 化合物及其制备方法具有式（I）或其相应的盐，其中R表示下式的基团：其中R 1表示恶唑啉基，-C 3位N，-CH 2 OR 2或这些 药物或化妆品组合物形式的化合物可用于治疗角质化障碍。

公开(公告)号：US4983627A

公开(公告)日：1991-01-08

申请号：US269811

申请日：1988-11-10

Applicant: Counde O'Yang ,  Walter Kurz ,  Keith A. M. Walker ,  Helen Y. Wu

Inventor： Counde O'Yang ,  Walter Kurz ,  Keith A. M. Walker ,  Helen Y. Wu

IPC: C07C33/042 ,  C07C33/05 ,  C07C33/14 ,  C07C33/30 ,  C07C35/31 ,  C07C45/29 ,  C07C45/42 ,  C07C45/45 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C45/68 ,  C07C49/513 ,  C07C49/557 ,  C07C49/633 ,  C07C49/693 ,  C07C49/743 ,  C07C62/32 ,  C07C69/732 ,  C07C251/44 ,  C07C405/00 ,  C07D317/72 ,  C07F7/18

CPC classification number: C07F7/1864 ,  C07C251/44 ,  C07C33/042 ,  C07C33/05 ,  C07C33/14 ,  C07C33/30 ,  C07C35/31 ,  C07C405/0083 ,  C07C45/292 ,  C07C45/42 ,  C07C45/455 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C45/673 ,  C07C45/68 ,  C07C49/513 ,  C07C49/557 ,  C07C49/633 ,  C07C49/693 ,  C07C49/743 ,  C07C62/32 ,  C07C69/732 ,  C07D317/72 ,  C07F7/1852 ,  C07F7/1856 ,  C07C2102/22 ,  Y10S514/824

Abstract: Compounds useful in treating or preventing gastrointestinal ulcers and in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): ##STR1## wherein: A is --C.tbd.C--, trans --HC.dbd.CH--, trans --CH.dbd.CHCH.sub.2 -- or --CH.sub.2 CH.sub.2 --;X is lower alkyl of 1-6 carbon atoms;Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl);n is an integer from 2-4;R.sub.1 is --CH.sub.2 OH, --CHO, --CO.sub.2 R or --CO.sub.2 H, and the olefin formed by the R.sub.1 (CH.sub.2).sub.n CH.dbd. moiety is either (E) or (Z);R.sub.2 is hydrogen or methyl, or optionally --CH.dbd.CH.sub.2 when A is trans --CH.dbd.CHCH.sub.2 --; andR.sub.3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, ##STR2## --(CH.sub.2).sub.m -phenyl or CH.sub.2 O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen. in which:a is an integer of 0, 1 or 2;b is an integer of 3-7;m is an integer of 0, 1 or 2; andR is ##STR3## wherein X' is ##STR4## in which each R.sub.4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, or a pharmaceutically acceptable, non-toxic salt or ester thereof.

Abstract translation: （1），（2）和（3）中描述了可用于治疗或预防胃肠溃疡和治疗心血管疾病如血栓形成，高血压和动脉粥样硬化的化合物：（2） + TR 。

公开(公告)号：US4678805A

公开(公告)日：1987-07-07

申请号：US891509

申请日：1986-07-28

Applicant: Arthur F. Kluge ,  Helen Y. Wu

Inventor： Arthur F. Kluge ,  Helen Y. Wu

IPC: C07C43/178 ,  A61K31/045 ,  A61K31/085 ,  A61K31/11 ,  A61K31/19 ,  A61K31/215 ,  A61P1/04 ,  A61P3/06 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07C27/00 ,  C07C29/147 ,  C07C33/05 ,  C07C35/31 ,  C07C35/52 ,  C07C41/00 ,  C07C45/00 ,  C07C45/29 ,  C07C45/30 ,  C07C45/45 ,  C07C45/59 ,  C07C45/65 ,  C07C45/72 ,  C07C47/26 ,  C07C47/267 ,  C07C47/27 ,  C07C47/273 ,  C07C47/277 ,  C07C49/21 ,  C07C49/217 ,  C07C49/235 ,  C07C49/633 ,  C07C49/687 ,  C07C49/743 ,  C07C49/747 ,  C07C51/00 ,  C07C53/136 ,  C07C59/42 ,  C07C59/46 ,  C07C59/54 ,  C07C59/56 ,  C07C59/62 ,  C07C59/72 ,  C07C67/00 ,  C07C69/02 ,  C07C69/73 ,  C07C69/732 ,  C07C69/734 ,  C07C231/00 ,  C07C231/12 ,  C07C233/12 ,  C07C233/16 ,  C07C233/24 ,  C07C233/25 ,  C07C233/64 ,  C07C233/75 ,  C07C275/28 ,  C07C275/34 ,  C07F7/18 ,  H04N9/79 ,  C07C69/74

CPC classification number: C07C59/46 ,  C07C35/31 ,  C07C403/08 ,  C07C403/16 ,  C07C45/292 ,  C07C45/305 ,  C07C45/455 ,  C07C45/59 ,  C07C45/65 ,  C07C45/72 ,  C07C47/267 ,  C07C47/27 ,  C07C47/273 ,  C07C47/277 ,  C07C49/21 ,  C07C49/217 ,  C07C49/235 ,  C07C49/633 ,  C07C49/687 ,  C07C49/743 ,  C07C49/747 ,  C07C59/56 ,  C07F7/1856 ,  H04N9/7921 ,  C07B2200/07 ,  C07B2200/09 ,  C07C2101/14

Abstract: Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): ##STR1## wherein: Y is exo-(lower alkyl) or endo-(lower alkyl);n is 2 or 3;R.sub.1 is CH.sub.2 OH, CHO, CO.sub.2 R or CO.sub.2 H;R.sub.2 is hydrogen or methyl; andR.sub.3 is linear or branched alkyl having 5-10 carbon atoms, ##STR2## or --(CH.sub.2).sub.m -phenyl optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen,in whicha is 0, 1 or 2;b is 3-7;m is 1 or 2; andR is ##STR3## wherein X is ##STR4## in which each R.sub.4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

Abstract translation: （1），（2）和（3）中描述的化合物是：治疗心血管疾病如血栓形成，高血压和动脉粥样硬化的化合物是：（1） 其中：Y为外 - （低级烷基）或内 - （低级烷基）; n为2或3; R1是CH2OH，CHO，CO2R或CO2H; R2是氢或甲基; 并且R 3是具有5-10个碳原子的直链或支链烷基，或任选被低级烷基，低级烷氧基，三氟甲基或卤素取代的 - （CH 2）m - 苯基，其中a是0,1或2; b为3-7; m为1或2; 并且R为，其中X为每个R 4独立地为氢或具有1-6个碳原子的低级烷基，其药学上可接受的无毒盐和酯。

公开(公告)号：US4497830A

公开(公告)日：1985-02-05

申请号：US381609

申请日：1982-05-24

Applicant: Werner Skuballa ,  Bernd Raduechel ,  Helmut Vorbrueggen ,  Jorge Casals-Stenzel ,  Ekkehard Schillinger ,  Gerda Mannesmann ,  Bob Nieuweboer

Inventor： Werner Skuballa ,  Bernd Raduechel ,  Helmut Vorbrueggen ,  Jorge Casals-Stenzel ,  Ekkehard Schillinger ,  Gerda Mannesmann ,  Bob Nieuweboer

IPC: A61K31/557 ,  A61P43/00 ,  C07C29/147 ,  C07C33/05 ,  C07C33/12 ,  C07C41/26 ,  C07C43/178 ,  C07C405/00 ,  C07D309/12 ,  C07D317/72 ,  C07F9/40

CPC classification number: C07D317/72 ,  C07C33/12 ,  C07C405/0083 ,  C07C43/178 ,  C07D309/12 ,  C07F9/4015

Abstract: Compounds of Formula I ##STR1## wherein X is oxygen or CH.sub.2 ;A is CH.sub.2 --CH.sub.2, trans-CH.dbd.CH or C.tbd.C;W is free or functionally modified hydroxymethylene or free or functionally modified ##STR2## and the OH groups may be in the .alpha.- or the .beta.-position; D is straight chain or branched, saturated or unsaturated hydrocarbon aliphatic of from 1 to 10 carbon atoms, which may be substituted by fluorine;E is C.tbd.C or CR.sub.3 .dbd.CR.sub.4, R.sub.3 and R.sub.4 being different and being hydrogen or alkyl of 1 to 5 carbon atoms;R.sub.1 is free or functionally modified hydroxy; andR.sub.2 is alkyl, cycloalkyl, optionally substituted aryl or heterocyclic,have valuable pharmacological properties, e.g., hypotensive and bronchodilatory characteristics. They can furthermore be used for prophylaxis and therapy of coronary infarct and as a treatment for stroke. They are produced by means of reduction of the corresponding 1-carbonic acid derivatives.

Abstract translation: 式I的化合物其中X是氧或CH 2; A是CH 2 -CH 2，反式-CH = CH或C 3 C; W是游离或官能改性的羟基亚甲基或游离或功能修饰的“IMAGE”，OH基可以是α或β位; D是可以被氟取代的具有1至10个碳原子的直链或支链，饱和或不饱和的烃脂族; E为C 3或C 3或CR 3 = CR 4，R 3和R 4不同，为氢或1至5个碳原子的烷基; R1是游离或官能改性的羟基; 和R2是烷基，环烷基，任选取代的芳基或杂环，具有有价值的药理学性质，例如降血压和支气管扩张特征。 它们还可用于冠状动脉梗塞的预防和治疗以及中风治疗。 它们是通过还原相应的1-碳酸衍生物生产的。

公开(公告)号：US4223167A

公开(公告)日：1980-09-16

申请号：US877759

申请日：1978-02-14

Applicant: Brian J. Willis ,  Philip A. Christenson ,  Derek H. R. Barton

Inventor： Brian J. Willis ,  Philip A. Christenson ,  Derek H. R. Barton

IPC: C07C69/608 ,  C07C1/24 ,  C07C27/00 ,  C07C29/136 ,  C07C29/147 ,  C07C29/17 ,  C07C29/36 ,  C07C29/38 ,  C07C31/137 ,  C07C33/05 ,  C07C45/41 ,  C07C45/44 ,  C07C47/225 ,  C07C67/00 ,  C07C69/74 ,  C07C231/00 ,  C07C235/26 ,  C07C253/00 ,  C07C255/31 ,  C07D303/04 ,  C07D307/94 ,  C07D311/94 ,  C11B9/00 ,  C07C31/13 ,  C07C33/02

CPC classification number: C07C29/147 ,  C07C1/24 ,  C07C255/00 ,  C07C29/17 ,  C07C29/172 ,  C07C29/177 ,  C07C29/36 ,  C07C29/38 ,  C07C45/41 ,  C07C45/44 ,  C07C47/225 ,  C07C69/74 ,  C07D303/04 ,  C07D307/94 ,  C07D311/94 ,  C07C2102/42

Abstract: This invention concerns processes for preparing .beta.-santalol, .beta.-santalene, dihydro-.beta.-santalol, tetrahydro-.beta.-santalol and related compounds from camphene. The invention further concerns novel compounds useful as intermediates in these processes and as fragrance adjuncts.

Abstract translation: 本发明涉及从camp烯制备β-檀香醇，β-檀香烃，二氢-β-檀香醇，四氢-β-檀香醇和相关化合物的方法。 本发明还涉及可用作这些方法中的中间体和作为香料助剂的新化合物。

公开(公告)号：US4206151A

公开(公告)日：1980-06-03

申请号：US972005

申请日：1978-12-21

Applicant: Charles V. Grudzinskas

Inventor： Charles V. Grudzinskas

IPC: A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C29/10 ,  C07C29/40 ,  C07C33/05 ,  C07C45/30 ,  C07C45/45 ,  C07C45/59 ,  C07C45/71 ,  C07C49/707 ,  C07C49/743 ,  C07C49/753 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/32 ,  C07F7/18 ,  C07F7/22 ,  C07C35/06

CPC classification number: C07D307/32 ,  C07C29/10 ,  C07C29/40 ,  C07C33/05 ,  C07C405/0016 ,  C07C405/0025 ,  C07C45/305 ,  C07C45/45 ,  C07C45/59 ,  C07C45/71 ,  C07C49/707 ,  C07C49/743 ,  C07C49/753 ,  C07F7/1852 ,  C07F7/2212 ,  Y02P20/55

Abstract: This disclosure describes novel 15-deoxy-16 hydroxy-16-substituted prostanoic acid analogs in which the C-1 carboxyl is replaced by a primary alcohol and carboxylic acid esters, carbonates and carbomates thereof. The prostanoic carbinols and carboxylic acid esters thereof described herein have utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.

Abstract translation: 本公开描述了新的15-脱氧-16羟基-16-取代的前列腺烷酸类似物，其中C 1羧基被伯醇和羧酸酯，碳酸酯和碳酸酯代替。 本文所述的前列腺烷醇和羧酸酯可用作作为降压药的支气管扩张剂，以及用于控制过度胃分泌的药剂。

公开(公告)号：US4128729A

公开(公告)日：1978-12-05

申请号：US780685

申请日：1977-03-23

Applicant: James M. Sanders ,  Joaquin F. Vinals ,  Frederick L. Schmitt

Inventor： James M. Sanders ,  Joaquin F. Vinals ,  Frederick L. Schmitt

IPC: C07C5/25 ,  C07C29/40 ,  C07C33/14 ,  C11B9/00 ,  C11D3/50 ,  C07C33/05

CPC classification number: C07C5/2531 ,  C07C29/40 ,  C07C33/14 ,  C07C45/69 ,  C07C5/25 ,  C11B9/0046 ,  C11D3/50 ,  C07C2102/44

Abstract: Described are bicyclo[2.2.2]-octene derivatives having the formula selected from the group consisting of ##STR1## and mixtures thereof.

Abstract translation: 描述了具有选自 及其混合物的式的双环[2.2.2] - 辛烯衍生物。

公开(公告)号：US4126756A

公开(公告)日：1978-11-21

申请号：US782603

申请日：1977-03-29

Applicant: Paul R. Stapp

Inventor： Paul R. Stapp

IPC: C07C33/025 ,  C07C33/05 ,  C07C29/00

CPC classification number: C07C33/025 ,  C07C33/05 ,  Y02P20/582

Abstract: The yield of alkenols and cycloalkenols is substantially improved by carrying out the reaction of olefins with formaldehyde in the presence of selected catalysts. In accordance with one embodiment, alk-3-en-1-ols are produced in good yields from isobutylene and formaldehyde in the presence of organic carboxylic acid salts of Group IB metals.

Abstract translation: 在选择的催化剂存在下，通过进行烯烃与甲醛的反应，烯醇和环烯醇的收率大大提高。 根据一个实施方案，在IB族金属的有机羧酸盐存在下，以异丁烯和甲醛的良好收率生产烷-3-烯-1-醇。