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公开(公告)号：US08327903B2
公开(公告)日：2012-12-11
申请号：US12000742
申请日：2007-12-17
IPC分类号： B29C43/30
CPC分类号： A61F13/02 , A61F13/00991 , A61F2013/0296 , A61K9/7061 , Y10T156/1724 , Y10T156/1798
摘要： A manufacturing apparatus of a transdermal absorption preparation includes an adhesive sheet supplying part to feed out a band-like first adhesive sheet into a runway, wherein the adhesive sheet has at least an adhesive layer comprising an adhesive and a liquid component compatible with the adhesive, a drug liquid application part to apply a given amount of a drug liquid to an adhesive face, and a traveling section for impregnation which is set in the runway after the drug liquid application part, during which the adhesive sheet is run for a period necessary for the applied drug liquid to soak into the adhesive layer without contact of the drug liquid coated face of the adhesive layer with other members.
摘要翻译： 透皮吸收制剂的制造装置包括将带状第一粘合片输送到跑道中的粘合片供给部，其中，所述粘合片至少具有粘合剂层和与所述粘合剂相容的液体成分， 药液施加部，将给定量的药液施加到粘合面上;以及浸渍移动部，其设置在药液施加部之后的跑道中，粘贴片的运行期间为 将所施加的药液浸入粘合剂层中，而不与粘合剂层的药液涂布面与其它构件接触。
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公开(公告)号：US20080149277A1
公开(公告)日：2008-06-26
申请号：US12000742
申请日：2007-12-17
IPC分类号： B32B37/12
CPC分类号： A61F13/02 , A61F13/00991 , A61F2013/0296 , A61K9/7061 , Y10T156/1724 , Y10T156/1798
摘要： A manufacturing apparatus of a transdermal absorption preparation, comprising an adhesive sheet supplying part A to feed out a band-like first adhesive sheet 3 into a runway, wherein the adhesive sheet has at least an adhesive layer comprising an adhesive and a liquid component compatible with the adhesive, a drug liquid application part B to apply a given amount of a drug liquid to an adhesive face 2b, and a traveling section C for impregnation which is set in the runway after the drug liquid application part B, during which the adhesive sheet is run for a period necessary for the applied drug liquid to soak into the adhesive layer without contact of the drug liquid coated face of the adhesive layer with other members.
摘要翻译： 一种透皮吸收制剂的制造装置，其特征在于，包括粘合片供给部A将带状的第一粘合片3送入到跑道中，所述粘合片至少具有粘合剂层，所述粘合剂层包含粘合剂和与 粘合剂，将药液施加给粘合面2b的药液施加部B和在药液施加部B之后设置在跑道中的浸渍行进部C，在该过程中粘合剂 将片材运行所需的时间，使所施加的药液浸没到粘合剂层中，而不会使粘合剂层的药物液体涂覆面与其它部件接触。
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公开(公告)号：US20070087043A1
公开(公告)日：2007-04-19
申请号：US11546302
申请日：2006-10-12
IPC分类号： A61K31/4439 , A61K9/70
CPC分类号： A61K9/7061 , A61K31/465 , A61K47/14
摘要： The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off. The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.
摘要翻译： 本发明提供了一种尼古丁透皮制剂的制备方法，其能够方便且经济地制备尼古丁透皮制剂，同时保持高精度的含量均匀性，其能够同时制备粘合期间的固定性和柔软感， 与剥离时的皮肤刺激性降低，粘合性优异。 本发明提供了含量均匀性优异的尼古丁透皮制剂，同时达到粘合时的固定性和柔软感，并且在剥离时显示出减少的皮肤刺激性。 本发明提供一种制备含有载体和粘合剂层的制剂的方法，该粘合剂层含有尼古丁和与粘合剂相容的液体成分的粘合剂层，该方法包括（1）提供粘合剂层，其中尼古丁的接触角 含尼古丁之前的粘合剂层为20-60°，和（2）向粘合剂层施加尼古丁以允许将尼古丁吸收到粘合剂层中，以及含有形成在其上的载体和粘合剂层的制剂，该粘合剂 包括尼古丁和与粘合剂相容的液体成分的层，其中尼古丁与包含尼古丁之前的粘合剂层的接触角为20-60°。
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公开(公告)号：US08506991B2
公开(公告)日：2013-08-13
申请号：US11546302
申请日：2006-10-12
IPC分类号： A61L15/16 , A61K9/70 , A61K31/465 , A61K47/14
CPC分类号： A61K9/7061 , A61K31/465 , A61K47/14
摘要： The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off.The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.
摘要翻译： 本发明提供了一种尼古丁透皮制剂的制备方法，其能够方便且经济地制备尼古丁透皮制剂，同时保持高精度的含量均匀性，其能够同时制备粘合期间的固定性和柔软感， 与剥离时的皮肤刺激性降低，粘合性优异。 本发明提供了含量均匀性优异的尼古丁透皮制剂，同时达到粘合时的固定性和柔软感，并且在剥离时显示出减少的皮肤刺激性。 本发明提供一种制备含有载体和粘合剂层的制剂的方法，该粘合剂层含有尼古丁和与粘合剂相容的液体成分的粘合剂层，该方法包括（1）提供粘合剂层，其中尼古丁的接触角 含尼古丁之前的粘合剂层为20-60°，和（2）向粘合剂层施加尼古丁以允许将尼古丁吸收到粘合剂层中，以及含有形成在其上的载体和粘合剂层的制剂，该粘合剂 包括尼古丁和与粘合剂相容的液体成分的层，其中尼古丁与包含尼古丁之前的粘合剂层的接触角为20-60°。
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公开(公告)号：US20070212520A1
公开(公告)日：2007-09-13
申请号：US11716694
申请日：2007-03-12
申请人： Kenji Furumori , Hiroshi Hatanaka , Tsuyoshi Kasahara , Tatsumi Ishikawa , Shunetsu Kikuchi , Tomoyuki Ota
发明人： Kenji Furumori , Hiroshi Hatanaka , Tsuyoshi Kasahara , Tatsumi Ishikawa , Shunetsu Kikuchi , Tomoyuki Ota
IPC分类号： B32B3/10
CPC分类号： A61F13/0269 , Y10T428/14 , Y10T428/24298 , Y10T428/24322
摘要： The present invention relates to A pressure-sensitive adhesive tape or sheet comprising a substrate comprising a nonwoven fabric and a pressure-sensitive adhesive layer disposed on at least one side of the substrate, the pressure-sensitive adhesive tape or sheet having a plurality of penetrating pores which penetrate the substrate and the pressure-sensitive adhesive layer so that corners of the penetrating pores are aligned in at least one direction, the penetrating pores having a flat polygonal shape, and in which, the penetration pore has, among the corners aligned in one direction, at least two corners facing each other in one direction each having an angle of less than 90°; a pressure-sensitive adhesive tape or sheet comprising a substrate comprising a nonwoven fabric and a pressure-sensitive adhesive layer disposed on at least one side of the substrate, the pressure-sensitive adhesive tape or sheet having a plurality of pores aligned in at least one direction, the pores having a shape in which at least two corners facing each other in one direction each has an angle of less than 90°, the pores including penetrating and non-penetrating pores, the pressure-sensitive adhesive tape or sheet having a penetration ratio of a series of adjacent pores of 50% or more and less than 100%, and in which the penetrating and non-penetrating pores are disposed randomly; and a pressure-sensitive adhesive tape or sheet comprising a substrate including nonwoven fabric and a pressure-sensitive adhesive layer disposed on at least one side of the substrate, the pressure-sensitive adhesive tape or sheet having a plurality of pores so that edges of the pores are aligned in at least one direction, in which a distance between one alignment of the pores and another alignment of the pores adjacent thereto is in the range of 1 to 15 mm.
摘要翻译： 本发明涉及一种压敏粘合带或片，其包含基材，该基材包括非织造织物和设置在所述基材的至少一侧上的压敏粘合剂层，所述压敏粘合带或片材具有多个穿透性 穿透基材和压敏粘合剂层的孔，使得贯通孔的角部在至少一个方向上排列，贯通孔具有平坦的多边形，并且其中贯通孔具有在 一个方向，至少两个角部在一个方向上彼此面对，每个角度小于90°; 一种压敏粘合带或片，其包含基底，该基底包括布置在所述基底的至少一侧上的非织造织物和压敏粘合剂层，所述压敏粘合带或片具有至少一个对齐的多个孔 方向，具有这样的形状的孔，其中在一个方向上彼此面对的至少两个角各自具有小于90°的角度，所述孔包括穿透孔和非穿透孔，所述压敏粘合带或片具有渗透性 50％以上且小于100％的一系列相邻孔的比例，其中穿透孔和非穿透孔随机布置; 以及包含非织造布的基板和设置在所述基板的至少一侧上的压敏粘合剂层的压敏粘合带或片，所述压敏粘合带或片具有多个孔， 孔至少在一个方向上排列，其中孔的一个取向和与其相邻的孔的另一取向之间的距离在1至15mm的范围内。
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