公开(公告)号：US20220362112A1

公开(公告)日：2022-11-17

申请号：US17766060

申请日：2020-10-01

Applicant: Shiseido Company, Ltd.

Inventor： Haruhiko INOUE ,  Masaki KITAJIMA

IPC: A61K8/06 ,  A61K8/92 ,  A61K8/25 ,  A61K8/34 ,  A61K8/81

Abstract: A W/O/W emulsion composition comprising a large amount of silicone oil and having a high viscosity and a high stability is provided.
The W/O/W emulsion composition comprises: an inner aqueous phase; an oil phase in which the inner aqueous phase is dispersed; and an outer aqueous phase in which the oil phase is dispersed, wherein the inner aqueous phase comprises an osmotic pressure regulator that prepares the inner aqueous phase to have a higher osmotic pressure than the outer aqueous phase, the oil phase comprises a silicone oil that is 0.5 times by mass or greater of the total oil phase, and a silicone-based surfactant having a silicone skeleton as a main skeleton and a hydrophilic group in a side chain, and the outer aqueous phase comprises a polyol and an alkyl-modified carboxyvinyl polymer.

公开(公告)号：US20230087483A1

公开(公告)日：2023-03-23

申请号：US17908350

申请日：2021-03-04

Applicant: Shiseido Company, Ltd.

Inventor： Kento UENO ,  Haruhiko INOUE ,  Hidehito MUNAKATA ,  Kei WATANABE

IPC: A61K8/06 ,  A61Q19/00 ,  A61K8/894

Abstract: An object of the present invention is to provide, regarding a composition containing a nanodisc composed of a silicone-based surfactant, a nanodisc-containing composition having an improved stability of an emulsion composition.
For achieving the object, provided is an oil-in-water emulsion composition containing (A) an aqueous phase, (B) an oil phase, and (C) polyoxyalkylene-modified silicone. When the oil-in-water emulsion composition contains 1 to 35% by mass in total of ethyl alcohol and dipropylene glycol in (A) the aqueous phase, 1 to 50% by mass of (B) the oil phase, and 0.2 to 5% by mass of (C) based on the whole composition, a nanodisc is formed and the emulsion state is stable.