公开(公告)号：US11440920B2

公开(公告)日：2022-09-13

申请号：US16671545

申请日：2019-11-01

Applicant: Showa University

Inventor： Takashi Itoh ,  Kazuhiro Nagata ,  Takuya Kanemitsu ,  Michiko Miyazaki ,  Yuichiro Tomisawa ,  Misa Mori

IPC: C07D493/04 ,  C07D311/58 ,  C07C67/30 ,  C07C67/31

Abstract: The present invention provides a compound having a dihydropyran structure, a method of producing a compound having a dihydropyran structure, a method of producing Pre-SMTP, a method of producing a group of SMTPs, and a pharmaceutical composition. The compound having a dihydropyran structure can be a useful intermediate in the chemically producing a group of Pre-SMTP and SMTP. Specifically, the compound having a dihydropyran structure is represented by the following formula (1), wherein: R3Si is a silyl group selected from TMS: trimethylsilyl, TES: triethysilyl, TBS (TBDMS): tert-butyldimethylsil, TIPS: triisopropylsilyl, TBDPS: tert-butyldiphenylsilyl, X is selected from COOH, CHO, and —CH═C(CH3)—(CH2)2—CH═C(CH3)2.