公开(公告)号：US20060122198A1

公开(公告)日：2006-06-08

申请号：US10560598

申请日：2004-06-25

申请人： Shunji Ichikawa ,  Chiemi Takashima ,  Hironori Imma ,  Junichi Shimada

发明人： Shunji Ichikawa ,  Chiemi Takashima ,  Hironori Imma ,  Junichi Shimada

IPC分类号： A61K31/522

CPC分类号： A61K31/522 ,  C07D473/12

摘要： An antiepileptic agent which contains either a xanthine derivative represented by the formula (I): (I) (wherein R1, R2, and R3 are the same or different and each represents hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; R4 represents cycloalkyl, —(CH2)n.R5, or the formula (II); (II) and X1 and X2 are the same or different and each represents oxygen or sulfur) or a pharmacologically acceptable salt thereof as an active ingredient.

摘要翻译： 含有由式（I）表示的黄嘌呤衍生物：（I）（其中R 1，R 2，R 2和R 3）的抗癫痫剂， SUP>相同或不同，各自表示氢，低级烷基，低级烯基或低级炔基; R 4表示环烷基， - （CH 2）n 或者式（II）;（II）和X 1和X 2相同或不同 并且各自表示氧或硫）或其药理学上可接受的盐作为活性成分。

公开(公告)号：US20060252679A1

公开(公告)日：2006-11-09

申请号：US10525324

申请日：2003-08-22

申请人： Mayumi Saki ,  Hiromi Nonaka ,  Hiromasa Miyaji ,  Shunji Ichikawa ,  Chiemi Takashima ,  Tsutomu Matsumura ,  Hitoshi Arai ,  Katsutoshi Sasaki ,  Choei Kobatake ,  Yukihito Tsukumo ,  Kyoichiro Iida ,  Takeshi Kuboyama ,  Haruhiko Manabe

发明人： Mayumi Saki ,  Hiromi Nonaka ,  Hiromasa Miyaji ,  Shunji Ichikawa ,  Chiemi Takashima ,  Tsutomu Matsumura ,  Hitoshi Arai ,  Katsutoshi Sasaki ,  Choei Kobatake ,  Yukihito Tsukumo ,  Kyoichiro Iida ,  Takeshi Kuboyama ,  Haruhiko Manabe

IPC分类号： A61K38/17 ,  A61K48/00

CPC分类号： C07D401/14 ,  A61K31/519 ,  A61K31/55 ,  A61K31/7088 ,  A61K48/00 ,  C07D403/06 ,  C07D417/14 ,  C07D471/04 ,  G01N33/5088

摘要： The present invention provides an agent for prevention and/or treatment of itching comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents substituted or unsubstituted lower alkyl, etc.; R2 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, etc.; n represents 0 or 1; X represents —(CH2)2—, etc.; and Y represents the formula (II); (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, substituted or unsubstituted lower alkyl, etc.; and Z3 represents hydrogen, substituted or unsubstituted lower alkyl, etc.)]

摘要翻译： 本发明提供了用于预防和/或治疗瘙痒的药剂，其包含能够抑制作为活性成分的GPR4的信号转导所涉及的功能的物质。 它还提供由式（I）表示的含氮三环化合物或其季铵盐或其药学上可接受的盐; [其中R 1表示取代或未取代的低级烷基等; R 2表示氢，取代或未取代的低级烷基等; R 3和R 4相同或不同，各自表示氢，低级烷基等; n表示0或1; X表示 - （CH 2 2）2 - 等; Y表示式（II）; （其中W表示CH或氮原子; Z 1和Z 2相同或不同，各自表示氢，取代或未取代的低级烷基等; Z 代表氢，取代或未取代的低级烷基等）]