公开(公告)号：US20140088052A1

公开(公告)日：2014-03-27

申请号：US14000816

申请日：2012-02-27

申请人： Shyam Biswal ,  Rajesh Thimmulappa ,  Sarvesh Kumar ,  Sanjay V. Malhotra ,  Vineet Kumar ,  Kim Jung-Hyun

发明人： Shyam Biswal ,  Rajesh Thimmulappa ,  Sarvesh Kumar ,  Sanjay V. Malhotra ,  Vineet Kumar ,  Kim Jung-Hyun

IPC分类号： A61K31/121 ,  A61K45/06 ,  C07C49/84

CPC分类号： A61K31/121 ,  A61K45/06 ,  C07C49/813 ,  C07C49/84 ,  C07C205/45

摘要： Compounds and methods for treating or preventing a disease, disorder or condition associated with an Nrf2-regulated pathway, including those associated with an autoimmune disease, comorbidity associated with diabetes, such as retinopathy and nephropathy, bone marrow transplant for leukemia and related cancers, bone marrow deficiencies, inborn errors of metabolism, and other immune disorders, oxidative stress, respiratory infection, ischemia, neurodegenerative disorders, radiation injury, neutropenia caused by chemotherapy, autoimmunity, and congenital neutropenic disorders, and for restoring a corticosteroid responsiveness, in a subject are provided.

摘要翻译： 用于治疗或预防与Nrf2调节途径相关的疾病，病症或病症的化合物和方法，包括与自身免疫性疾病相关的疾病，与糖尿病相关的共病，例如视网膜病变和肾病，白血病骨髓移植和相关癌症，骨骼 受试者骨髓缺陷，代谢紊乱，其他免疫疾病，氧化应激，呼吸道感染，局部缺血，神经退行性疾病，放射性损伤，化疗引起的中性粒细胞减少，自身免疫和先天性中性粒细胞减少症，以及恢复皮质类固醇反应等） 提供。