公开(公告)号：US09751821B1

公开(公告)日：2017-09-05

申请号：US15586913

申请日：2017-05-04

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Manabu Yaosaka ,  Tomohisa Utsunomiya ,  Yuji Moriyama ,  Tomohiro Matsumoto ,  Kazutaka Matoba

IPC分类号： C07C45/72 ,  C07D413/14 ,  C07C51/367 ,  C07C231/12 ,  C07D213/04 ,  C07C67/343 ,  C07D249/08 ,  C07D233/60 ,  C07D401/04 ,  C07D413/12

CPC分类号： C07C45/72 ,  C07C45/66 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C51/353 ,  C07C51/367 ,  C07C51/377 ,  C07C65/40 ,  C07C67/327 ,  C07C67/343 ,  C07C67/347 ,  C07C69/65 ,  C07C231/12 ,  C07C253/30 ,  C07C319/20 ,  C07D213/30 ,  C07D213/50 ,  C07D213/61 ,  C07D233/14 ,  C07D249/08 ,  C07D261/04 ,  C07D401/04 ,  C07C323/22 ,  C07C235/84 ,  C07C255/56 ,  C07C69/76 ,  C07C49/813 ,  C07C65/38

摘要： There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

公开(公告)号：US09676692B2

公开(公告)日：2017-06-13

申请号：US14584642

申请日：2014-12-29

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Manabu Yaosaka ,  Tomohisa Utsunomiya ,  Yuji Moriyama ,  Tomohiro Matsumoto ,  Kazutaka Matoba

IPC分类号： C07C45/72 ,  C07C51/353 ,  C07C231/12 ,  C07D213/04 ,  C07C67/343 ,  C07D249/08 ,  C07D233/60 ,  C07D401/04 ,  C07D413/12 ,  C07D413/14 ,  C07C67/327 ,  C07C45/66 ,  C07C45/74 ,  C07C51/367 ,  C07C51/377

CPC分类号： C07C45/72 ,  C07C45/66 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C51/353 ,  C07C51/367 ,  C07C51/377 ,  C07C65/40 ,  C07C67/327 ,  C07C67/343 ,  C07C67/347 ,  C07C69/65 ,  C07C231/12 ,  C07C253/30 ,  C07C319/20 ,  C07D213/30 ,  C07D213/50 ,  C07D213/61 ,  C07D233/14 ,  C07D249/08 ,  C07D261/04 ,  C07D401/04 ,  C07C323/22 ,  C07C235/84 ,  C07C255/56 ,  C07C69/76 ,  C07C49/813 ,  C07C65/38

摘要： There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

公开(公告)号：US09611231B2

公开(公告)日：2017-04-04

申请号：US14683423

申请日：2015-04-10

申请人： E.I. du Pont de Nemours and Company

发明人： Gary David Annis

IPC分类号： C07D261/04 ,  C07C49/80 ,  C07C49/813 ,  C07D231/12 ,  C07C231/12 ,  C07D249/08 ,  C07D231/14 ,  C07D231/16 ,  C07C67/343 ,  C07C231/14 ,  C07C17/35 ,  C07C25/13 ,  C07C205/45 ,  C07D213/40 ,  C07D249/10 ,  C07D277/28 ,  C07C209/74 ,  C07C45/45 ,  C07C45/70

CPC分类号： C07D261/04 ,  C07C17/35 ,  C07C25/13 ,  C07C45/455 ,  C07C45/70 ,  C07C49/80 ,  C07C49/813 ,  C07C67/343 ,  C07C205/45 ,  C07C209/74 ,  C07C231/12 ,  C07C231/14 ,  C07C235/84 ,  C07D213/40 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D249/08 ,  C07D249/10 ,  C07D277/28 ,  C07C69/94 ,  C07C69/76 ,  C07C211/56

摘要： Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.

公开(公告)号：US20160333033A1

公开(公告)日：2016-11-17

申请号：US15218738

申请日：2016-07-25

申请人： Sun Yat-Sen University

发明人： Xianzhang Bu ,  Cuige Zhu ,  Xin Yue ,  Yinglin Zuo ,  Yu Chen ,  Gesi Wen

IPC分类号： C07F9/12 ,  C07C225/22 ,  C07C221/00 ,  C07C49/84 ,  C07C45/45 ,  C07C303/22 ,  C07C255/56 ,  C07C253/30 ,  C07D207/08 ,  C07C65/38 ,  C07C51/347 ,  C07C309/44 ,  C07F5/02 ,  C07C49/835

CPC分类号： C07F9/12 ,  C07C45/45 ,  C07C45/63 ,  C07C49/248 ,  C07C49/255 ,  C07C49/835 ,  C07C49/84 ,  C07C51/347 ,  C07C51/373 ,  C07C65/38 ,  C07C221/00 ,  C07C225/22 ,  C07C253/30 ,  C07C255/56 ,  C07C303/22 ,  C07C309/44 ,  C07D207/08 ,  C07D295/112 ,  C07D295/12 ,  C07F5/025 ,  C07C49/813

摘要： Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and have a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.

摘要翻译： 公开了邻苯基查耳酮化合物及其制备方法和用途。 邻苯基查耳酮化合物能够抑制肿瘤细胞中微管的聚集并影响细胞的有丝分裂，并且具有高的抗肿瘤活性。 该化合物还具有抑制各种肿瘤细胞增殖的作用，例如人卵巢癌细胞A2780，人结肠癌细胞HCT8，人乳腺癌细胞MCF7，人肺癌细胞A549，人结肠癌细胞SW480， 人鼻咽癌细胞CNE2，人肝癌细胞HepG2等纳米摩尔浓度。

公开(公告)号：US09461249B2

公开(公告)日：2016-10-04

申请号：US14505261

申请日：2014-10-02

申请人： Merck Patent GmbH

发明人： Horst Vestweber ,  Holger Heil ,  Philipp Stoessel ,  Arne Buesing ,  Amir Hossain Parham ,  Rocco Fortte

IPC分类号： H01L51/54 ,  C09K11/06 ,  H01L51/00 ,  C07C13/62 ,  C07C13/72 ,  C07C17/12 ,  C07C17/263 ,  C07C45/00 ,  C07C45/63 ,  C07C49/697 ,  C07C49/792 ,  C07C49/813 ,  C07C205/06 ,  C07C211/61 ,  C07D209/88 ,  C07D215/44 ,  C07D279/24 ,  C07D307/91 ,  C07D311/78 ,  C07D311/96 ,  C07D319/08 ,  C07D321/10 ,  C07D333/50 ,  C07D333/76 ,  C07D487/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07F9/53 ,  C07F9/6568 ,  C07F9/6571 ,  C09B57/00 ,  C07D307/94 ,  C07D491/048 ,  C07F5/02 ,  C07F9/50 ,  H01L51/50

CPC分类号： H01L51/006 ,  C07C13/62 ,  C07C13/72 ,  C07C17/12 ,  C07C17/2632 ,  C07C45/00 ,  C07C45/63 ,  C07C49/697 ,  C07C49/792 ,  C07C49/813 ,  C07C205/06 ,  C07C211/61 ,  C07C2603/54 ,  C07C2603/90 ,  C07D209/88 ,  C07D215/44 ,  C07D279/24 ,  C07D307/91 ,  C07D307/94 ,  C07D311/78 ,  C07D311/96 ,  C07D319/08 ,  C07D321/10 ,  C07D333/50 ,  C07D333/76 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04 ,  C07D495/04 ,  C07F5/027 ,  C07F9/5027 ,  C07F9/5325 ,  C07F9/5329 ,  C07F9/65685 ,  C07F9/657163 ,  C09B57/00 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1044 ,  C09K2211/1096 ,  C09K2211/185 ,  H01L51/002 ,  H01L51/0054 ,  H01L51/0055 ,  H01L51/0056 ,  H01L51/0058 ,  H01L51/0061 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/0081 ,  H01L51/0085 ,  H01L51/50 ,  H01L51/5036 ,  H01L51/5052 ,  H01L51/5092 ,  Y02E10/549 ,  Y02P70/521 ,  C07C25/22

摘要： The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer.

公开(公告)号：US20160264512A1

公开(公告)日：2016-09-15

申请号：US15028310

申请日：2014-10-09

申请人： THE TRUSTEES OF PRINCETON UNIVERSITY

发明人： John T. Groves ,  Wei Liu ,  Xiongyi Huang

IPC分类号： C07C69/65 ,  C07B59/00 ,  A61K51/04 ,  A61K31/137 ,  A61K31/198 ,  C07C311/09 ,  C07C233/14 ,  C07C49/255 ,  C07C49/813 ,  C07D231/12 ,  C07D217/20 ,  C07D207/16 ,  C07C233/18 ,  C07C271/16 ,  C07C271/14 ,  C07B39/00

CPC分类号： C07C69/65 ,  A61K31/137 ,  A61K31/198 ,  A61K51/0402 ,  C07B39/00 ,  C07B59/001 ,  C07B2200/05 ,  C07C22/08 ,  C07C25/13 ,  C07C49/255 ,  C07C49/697 ,  C07C49/755 ,  C07C49/813 ,  C07C69/63 ,  C07C233/07 ,  C07C233/14 ,  C07C233/18 ,  C07C255/10 ,  C07C271/14 ,  C07C271/16 ,  C07C311/09 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/32 ,  C07D207/16 ,  C07D209/48 ,  C07D215/06 ,  C07D215/18 ,  C07D217/20 ,  C07D231/12 ,  C07D333/54 ,  Y02P20/582

摘要： Fluorinated compounds are provided. Fluorinated compounds may be prepared by a method of halogenating a carbon containing compound having an sp3 C—H bond.

摘要翻译： 提供氟化合物。 氟化化合物可以通过卤化具有sp 3 C-H键的含碳化合物的方法来制备。

公开(公告)号：US20150366834A1

公开(公告)日：2015-12-24

申请号：US14825699

申请日：2015-08-13

申请人： BIKAM PHARMACEUTICALS, INC.

发明人： David S. GARVEY

IPC分类号： A61K31/277 ,  A61K31/045 ,  A61K31/12

CPC分类号： C07D333/22 ,  A61K31/045 ,  A61K31/12 ,  A61K31/277 ,  C07C25/06 ,  C07C25/13 ,  C07C25/18 ,  C07C33/14 ,  C07C33/34 ,  C07C33/50 ,  C07C43/23 ,  C07C49/792 ,  C07C49/813 ,  C07C49/84 ,  C07C255/53 ,  C07C255/56 ,  C07C259/18 ,  C07C2601/14 ,  C07C2601/16 ,  C07D307/42 ,  C07D307/46 ,  C07D333/16

摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

摘要翻译： 公开的化合物可用于治疗由眼睛中累积的毒性视觉循环产物引起或与其相关的眼部疾病，例如干性成人黄斑变性，以及由突变视蛋白质蛋白质错误折叠引起或与之相关的病症，以及 /或视蛋白蛋白质的错位。 还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。 还公开了合成这些试剂的方法。

公开(公告)号：US09120725B2

公开(公告)日：2015-09-01

申请号：US13812894

申请日：2011-07-06

申请人： Milan Fedurco

发明人： Milan Fedurco

IPC分类号： C07C309/44 ,  C07C49/825 ,  C07C49/813 ,  C07C49/83 ,  H01M8/10 ,  C08G65/40 ,  C08L71/00 ,  B01D71/66 ,  C07C49/80 ,  C08G75/02

CPC分类号： C07C309/44 ,  B01D71/66 ,  C07C49/80 ,  C07C49/813 ,  C07C49/825 ,  C07C49/83 ,  C08G65/4025 ,  C08G75/02 ,  C08G2650/40 ,  C08L71/00 ,  H01M8/1025 ,  H01M8/1039 ,  H01M8/1088 ,  Y02E60/521 ,  Y02P70/56

摘要： An aromatic perfluoroalkane monomer is provided that can be used for the manufacture of a polymer membrane for a PEM-type fuel cell. The perfluoroalkane monomer has a structure corresponding to a formula (I): Z1—Ar3—C(O)—Ar1—(CF2)n—Ar2—C(O)—Ar4—Z2  (I) in which: n is in a range from 1 to 20; Ar1, Ar2, Ar3, Ar4 which are identical or different, represent a substituted or unsubstituted phenylene group; and Z1 and Z2, which are identical or different, represent an electrophilic or nucleophilic polymerizable functional group.

摘要翻译： 提供了可用于制造用于PEM型燃料电池的聚合物膜的芳族全氟烷烃单体。 全氟烷基单体具有对应于式（I）的结构：Z1-Ar3-C（O）-Ar1-（CF2）n-Ar2-C（O）-Ar4-Z2（Ⅰ），其中n为 范围从1到20; 相同或不同的Ar 1，Ar 2，Ar 3，Ar 4表示取代或未取代的亚苯基; 和相同或不同的Z 1和Z 2表示亲电或亲核可聚合官能团。

公开(公告)号：US20150210654A1

公开(公告)日：2015-07-30

申请号：US14683423

申请日：2015-04-10

申请人： E.I. du Pont de Nemours and Company

发明人： Gary David Annis

IPC分类号： C07D261/04 ,  C07C49/80 ,  C07C49/813 ,  C07D231/12 ,  C07C231/12 ,  C07D249/08 ,  C07D231/14 ,  C07D231/16 ,  C07C67/343 ,  C07C231/14

CPC分类号： C07D261/04 ,  C07C17/35 ,  C07C25/13 ,  C07C45/455 ,  C07C45/70 ,  C07C49/80 ,  C07C49/813 ,  C07C67/343 ,  C07C205/45 ,  C07C209/74 ,  C07C231/12 ,  C07C231/14 ,  C07C235/84 ,  C07D213/40 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D249/08 ,  C07D249/10 ,  C07D277/28 ,  C07C69/94 ,  C07C69/76 ,  C07C211/56

摘要： Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.

摘要翻译： 公开了一种制备式1化合物的方法，其中Q和Z如本公开中所定义，包括从包含式2化合物，式3化合物，包含至少一种选自 由式4的碱土金属氢氧化物组成的组，其中M是Ca，Sr或Ba，式4a的碱金属碳酸盐，其中M1是Li，Na或K，1,5-二氮杂双环[4.3.0]壬-5-烯和 1,8-二氮杂双环[5.4.0]十一碳-7-烯，以及能够与水形成低沸点共沸物的非质子传递溶剂。 还公开了制备式2化合物的方法，其包括（1）形成反应混合物，该反应混合物包含衍生自在存在下使式5的化合物（其中X为Cl，Br或I）与镁金属或烷基卤化镁接触的格利雅试剂 的醚溶剂，然后（2）使反应混合物与式6化合物（其中Y是OR 11或NR 12 R 13）和R 11，R 12和R 13如本公开所定义。 进一步公开的是制备式7化合物的方法，其中Q和Z如本公开所定义，使用式1的化合物，其特征在于通过上述方法制备式1化合物或使用制备的式1化合物 通过上述方法。

公开(公告)号：US08952175B2

公开(公告)日：2015-02-10

申请号：US12452347

申请日：2008-06-27

申请人： Manabu Yaosaka ,  Tomohisa Utsunomiya ,  Yuji Moriyama ,  Tomohiro Matsumoto ,  Kazutaka Matoba

发明人： Manabu Yaosaka ,  Tomohisa Utsunomiya ,  Yuji Moriyama ,  Tomohiro Matsumoto ,  Kazutaka Matoba

IPC分类号： C07D261/04 ,  C07D213/30 ,  C07C45/72 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C51/353 ,  C07C65/40 ,  C07C67/347 ,  C07C69/65 ,  C07C231/12 ,  C07C253/30 ,  C07C319/20 ,  C07D213/50 ,  C07D213/61 ,  C07D233/14 ,  C07D249/08 ,  C07D401/04

CPC分类号： C07C45/72 ,  C07C45/66 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C51/353 ,  C07C51/367 ,  C07C51/377 ,  C07C65/40 ,  C07C67/327 ,  C07C67/343 ,  C07C67/347 ,  C07C69/65 ,  C07C231/12 ,  C07C253/30 ,  C07C319/20 ,  C07D213/30 ,  C07D213/50 ,  C07D213/61 ,  C07D233/14 ,  C07D249/08 ,  C07D261/04 ,  C07D401/04 ,  C07C323/22 ,  C07C235/84 ,  C07C255/56 ,  C07C69/76 ,  C07C49/813 ,  C07C65/38

摘要： There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

摘要翻译： 提供了一种生产农药的新型中间体。 制备式（3）化合物的方法包括使式（4）的芳族酮化合物和式（5）的取代的苯乙酮化合物作为起始原料，在存在或不存在添加剂的情况下，在有机溶剂或水中反应 在有悬浮状态的基地的情况下。 一种方法可以包括使式（3）的化合物脱水。 一步法制备化合物（2）的方法包括使化合物（4）和化合物（5）反应得到化合物（3）。 此外，制备式（1）的异恶唑啉化合物的方法包括使任选被卤素原子取代的脂族或芳族烃溶剂中的化合物（2）与羟胺反应，加入选自相转移催化剂 ，C1-C6醇和非质子极性溶剂在碱和水的存在下反应。