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    SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS
    2.
    发明申请
    SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS 审中-公开
    用于基于光源分布的细胞外分泌的系统

    公开(公告)号：US20130052725A1

    公开(公告)日：2013-02-28

    申请号：US13285976

    申请日：2011-10-31

    申请人： Siavash Yazdanfar ,  Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

    IPC分类号： C12M1/42

    CPC分类号： C12M35/02

    摘要： A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 105 W/cm2; one or more optical elements; an imaging system to image the cells in a field of view; a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches optical beam from wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.

    摘要翻译： 用于递送外源分子的系统包括用于含有细胞和外源分子的载体; 红外（IR）光源，其产生平均功率密度至少大于105W / cm2的IR光束; 一个或多个光学元件; 成像系统，用于在视场中对细胞进行成像; 处理器，其在视野中产生用于细胞定位的信号; 用于光束的时间聚焦的光图案整形器以在细胞上产生宽场照明以透过细胞膜以传递外源分子; 以及将光束从宽场照明切换到聚焦照明的控制器。 处理器可操作地耦合到成像系统和光图案整形器，并且传输信号用于细胞的定位，以确保光束在细胞上的时间聚焦。

    METHOD OF RECORDING DATA IN AN OPTICAL DATA STORAGE MEDIUM AND AN OPTICAL DATA STORAGE MEDIUM
    4.
    发明申请
    METHOD OF RECORDING DATA IN AN OPTICAL DATA STORAGE MEDIUM AND AN OPTICAL DATA STORAGE MEDIUM 有权
    在光学数据存储介质中记录数据的方法和光学数据存储介质

    公开(公告)号：US20120328973A1

    公开(公告)日：2012-12-27

    申请号：US13164996

    申请日：2011-06-21

    申请人： Arunkumar Natarajan ,  Eugene Pauling Boden ,  Dmitry Vladimirovich Dylov ,  James Edward Pickett ,  Evgenia Mikhailovna Kim ,  Patrick Joseph McCloskey ,  Kwok Pong Chan ,  Victor Petrovich Ostroverkhov ,  Matthew Jeremiah Misner ,  Vijay Krishna Paruchuru

    发明人： Arunkumar Natarajan ,  Eugene Pauling Boden ,  Dmitry Vladimirovich Dylov ,  James Edward Pickett ,  Evgenia Mikhailovna Kim ,  Patrick Joseph McCloskey ,  Kwok Pong Chan ,  Victor Petrovich Ostroverkhov ,  Matthew Jeremiah Misner ,  Vijay Krishna Paruchuru

    IPC分类号： G11B7/0065

    CPC分类号： G11B7/0065 ,  G11B7/24044 ,  G11B7/245 ,  G11B7/246

    摘要： In accordance with one aspect of the present invention, a method for recording holographic data in an optical data storage medium is provided. The method includes (i) providing an optical data storage medium including: (a) a thermoplastic polymer matrix, (b) a latent acid generator, (c) a non-linear sensitizer, and (d) a reactant including a latent chromophore. The method further includes (ii) irradiating a volume element of the optical data storage medium with an interference pattern, said interference pattern including an incident radiation having a wavelength and an intensity sufficient to cause upper triplet energy transfer from the non-linear sensitizer to the latent acid generator, thereby generating an acid, wherein the latent acid generator is substantially non-responsive to said incident radiation. The method furthermore includes (iii) reacting at least one protected chromophore with the acid generated to form at least one chromophore, thereby causing a refractive index change within the volume element; and (iv) producing within the irradiated volume element refractive index variations corresponding to the interference pattern, thereby producing an optically readable datum. An optical data storage medium is also provided.

    摘要翻译： 根据本发明的一个方面，提供一种在光学数据存储介质中记录全息数据的方法。 该方法包括（i）提供光学数据存储介质，其包括：（a）热塑性聚合物基质，（b）潜伏酸发生剂，（c）非线性敏化剂，和（d）包含潜在发色团的反应物。 该方法还包括（ii）用干涉图案照射光学数据存储介质的体积元件，所述干涉图案包括入射辐射，该入射辐射具有足以使上部三线态能量从非线性敏化剂转移到 潜酸产生剂，从而产生酸，其中潜酸产生剂对所述入射辐射基本上不响应。 所述方法还包括（iii）使至少一种受保护的发色团与产生的酸形成至少一种生色团，由此引起体积元素内的折射率变化; 和（iv）在照射的体积元件内产生对应于干涉图案的折射率变化，由此产生光学可读数据。 还提供光学数据存储介质。

    Method of recording data in an optical data storage medium and an optical data storage medium
    5.
    发明授权
    Method of recording data in an optical data storage medium and an optical data storage medium 有权
    在光学数据存储介质和光学数据存储介质中记录数据的方法

    公开(公告)号：US08475975B2

    公开(公告)日：2013-07-02

    申请号：US13164996

    申请日：2011-06-21

    申请人： Arunkumar Natarajan ,  Eugene Pauling Boden ,  Dmitry Vladimirovich Dylov ,  James Edward Pickett ,  Evgenia Mikhailovna Kim ,  Patrick Joseph McCloskey ,  Kwok Pong Chan ,  Victor Petrovich Ostroverkhov ,  Matthew Jeremiah Misner ,  Vijay Krishna Paruchuru

    发明人： Arunkumar Natarajan ,  Eugene Pauling Boden ,  Dmitry Vladimirovich Dylov ,  James Edward Pickett ,  Evgenia Mikhailovna Kim ,  Patrick Joseph McCloskey ,  Kwok Pong Chan ,  Victor Petrovich Ostroverkhov ,  Matthew Jeremiah Misner ,  Vijay Krishna Paruchuru

    IPC分类号： G03H1/02

    CPC分类号： G11B7/0065 ,  G11B7/24044 ,  G11B7/245 ,  G11B7/246

    摘要： In accordance with one aspect of the present invention, a method for recording holographic data in an optical data storage medium is provided. The method includes (i) providing an optical data storage medium including: (a) a thermoplastic polymer matrix, (b) a latent acid generator, (c) a non-linear sensitizer, and (d) a reactant including a latent chromophore. The method further includes (ii) irradiating a volume element of the optical data storage medium with an interference pattern, said interference pattern including an incident radiation having a wavelength and an intensity sufficient to cause upper triplet energy transfer from the non-linear sensitizer to the latent acid generator, thereby generating an acid, wherein the latent acid generator is substantially non-responsive to said incident radiation. The method furthermore includes (iii) reacting at least one protected chromophore with the acid generated to form at least one chromophore, thereby causing a refractive index change within the volume element; and (iv) producing within the irradiated volume element refractive index variations corresponding to the interference pattern, thereby producing an optically readable datum. An optical data storage medium is also provided.

    摘要翻译： 根据本发明的一个方面，提供一种在光学数据存储介质中记录全息数据的方法。 该方法包括（i）提供光学数据存储介质，其包括：（a）热塑性聚合物基质，（b）潜伏酸发生剂，（c）非线性敏化剂，和（d）包含潜在发色团的反应物。 该方法还包括（ii）用干涉图案照射光学数据存储介质的体积元件，所述干涉图案包括入射辐射，该入射辐射具有足以使上部三线态能量从非线性敏化剂转移到 潜酸产生剂，从而产生酸，其中潜酸产生剂对所述入射辐射基本上不响应。 所述方法还包括（iii）使至少一种受保护的发色团与产生的酸形成至少一种生色团，由此引起体积元素内的折射率变化; 和（iv）在照射的体积元件内产生对应于干涉图案的折射率变化，由此产生光学可读数据。 还提供光学数据存储介质。