公开(公告)号：US20040102645A1

公开(公告)日：2004-05-27

申请号：US10716453

申请日：2003-11-20

申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

发明人： Piero Melloni ,  Alberto Cerri ,  Marco Santagostino

IPC分类号： C07C229/06

CPC分类号： C07C309/66 ,  C07B2200/07 ,  C07C51/377 ,  C07C51/48 ,  C07C51/56 ,  C07C69/63 ,  C07C227/08 ,  C07C227/32 ,  C07C55/32 ,  C07C229/22

摘要： An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formula (I): 1 where X1 and X2, which may be the same or different, are hydroxy, C1-C4 alkoxy, phenoxy, halogen, or X1 and X2, when taken together are an oxygen atom and the resulting compound is a derivative of succinic anhydride; Y is halogen, a mesyloxy or a tosyloxy group, and subsequent treatment with water, then with a base and then with trimethylamine.

摘要翻译： 通过用合适的还原剂还原式（I）化合物制备L-肉毒碱的内盐：其中X1和X2可以相同或不同，为羟基，C1-C4烷氧基，苯氧基， 卤素或X 1和X 2，当一起为氧原子时，所得化合物为琥珀酸酐的衍生物; Y是卤素，甲磺酰氧基或甲苯磺酰氧基，然后用水处理，然后用碱，然后用三甲胺处理。