公开(公告)号：US08907087B2

公开(公告)日：2014-12-09

申请号：US13927255

申请日：2013-06-26

申请人： Signal Pharmaceuticals, LLC

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella I. Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Jan Elsner

IPC分类号： C07D241/38 ,  C07D498/14 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof. Furthermore, provided are methods of preparing a compound of formula (III), Furthermore, provided are methods of preparing a compound of formula (VI),

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病 疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。 此外，提供制备式（III）化合物的方法。此外，提供制备式（VI）化合物的方法，

公开(公告)号：US20130289271A1

公开(公告)日：2013-10-31

申请号：US13927255

申请日：2013-06-26

申请人： SIGNAL PHARMACEUTICALS, LLC

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella I. Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Elizabeth Fultz ,  Rama Narla ,  Sabita Sankar ,  Jan Elsner

IPC分类号： C07D487/04 ,  C07D498/14

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

公开(公告)号：US09193692B2

公开(公告)日：2015-11-24

申请号：US14529261

申请日：2014-10-31

申请人： SIGNAL PHARMACEUTICALS, LLC

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella I. Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Jan Elsner

IPC分类号： C07D241/16 ,  C07D241/20 ,  C07D487/04 ,  C07D498/14

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof. Furthermore, provided herein are compounds having the following formulas (IV), (V), (VII) and (VIII): wherein R, R2, R3, R4, Hal and Hal2 are as defined herein, for preparation of the Heteroaryl Compounds.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病 疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。 此外，本文提供了具有下式（IV），（V），（VII）和（VIII）的化合物：其中R，R2，R3，R4，Hal和Hal2如本文所定义，用于制备杂芳基化合物。

公开(公告)号：US20150051397A1

公开(公告)日：2015-02-19

申请号：US14529261

申请日：2014-10-31

申请人： SIGNAL PHARMACEUTICALS, LLC

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella I. Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Jan Elsner

IPC分类号： C07D241/20

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病 疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。