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公开(公告)号：US20230338370A1
公开(公告)日：2023-10-26
申请号：US17976471
申请日：2022-10-28
发明人： Shuichan Xu , Kristen Mae Hege , Heather Raymon , Rama K. Narla
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985
摘要： Provided herein are methods for treating or preventing triple negative breast cancer or hormone receptor positive breast cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having triple negative breast cancer or hormone receptor positive breast cancer.
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![PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY](/abs-image/US/2023/04/20/US20230119470A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230119470A1
公开(公告)日：2023-04-20
申请号：US17681645
申请日：2022-02-25
发明人： Jan ELSNER , Kimberly E. Fultz , Roy L. HARRIS, III , Branden Gingsee LEE , Loui Thomas Madakamutil , Deborah S. Mortensen , Rama Krishna Narla , Garrick K. PACKARD , Patrick PAPA , Jason PARNES , Sophie Perrin-Ninkovic , Jennifer RIGGS , Sabita SANKAR , John J. Sapienza , Graziella I. Shevlin , Lida Tehrani , Weiming XU , Jingjing ZHAO
IPC分类号： C07D487/04 , C07D498/14 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
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3.发明申请公开(公告)号：US20210128565A1
公开(公告)日：2021-05-06
申请号：US17147127
申请日：2021-01-12
发明人： Matthew Alexander , Sogole Bahmanyar , John Frederick Boylan , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , JingJing Zhao
IPC分类号： A61K31/52 , C07D473/32 , A61P35/00 , A61K31/5377
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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公开(公告)号：US10975039B2
公开(公告)日：2021-04-13
申请号：US16871143
申请日：2020-05-11
发明人： Hon-Wah Man , Mohit Atul Kothare
IPC分类号： C07D239/48 , C07B59/00
摘要： Provided herein are isotopologues of Compound A, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided.
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公开(公告)号：US10919865B2
公开(公告)日：2021-02-16
申请号：US16291193
申请日：2019-03-04
发明人： Mercedes Delgado , Jan Elsner , Paul Erdman , Robert Hilgraf , Mark A. Nagy , Stephen Norris , David A. Paisner , Yoshitaka Satoh , Marianne Sloss , Jayashree Tikhe , Won Hyung Yoon
IPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D409/12 , C07D403/12 , C07D401/04 , C07D405/12
摘要： Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R1, R2, R3, and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.
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6.发明申请公开(公告)号：US20200237768A1
公开(公告)日：2020-07-30
申请号：US16846503
申请日：2020-04-13
发明人： Matthew Alexander , Sogole Bahmanyar , John Frederick Boylan , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , JingJing Zhao
IPC分类号： A61K31/52 , A61K31/5377 , A61P35/00 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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公开(公告)号：US10590089B2
公开(公告)日：2020-03-17
申请号：US16149393
申请日：2018-10-02
IPC分类号： A61K31/505 , C07D239/48
摘要： Provided are pharmaceutical compositions and dosage forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof. Also provided are methods of treating, managing, or preventing various disorders, such as diseases or disorders treatable or preventable by inhibition of a JNK pathway in mammals using such pharmaceutical compositions or dosage forms. Further provided are salts of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide and methods of preparation of such salts.
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公开(公告)号：US10517873B2
公开(公告)日：2019-12-31
申请号：US16266793
申请日：2019-02-04
发明人： Marie Georges Beauchamps , Antonio Christian Ferretti , Robert Hilgraf , Mohit Atul Kothare , Hon-Wah Man , Mark A. Nagy , Kelvin Hin-Yeong Yong , Nanfei Zou
IPC分类号： C07D239/42 , A61K31/505 , C07D239/48
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
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公开(公告)号：US10513519B2
公开(公告)日：2019-12-24
申请号：US16027503
申请日：2018-07-05
发明人： Zheng Chen , Paul F. Fernandez , Tracy L. Gaebele , Lianfeng Huang , Matthew J. Jackson , Matthew M. Kreilein , Xiaoling Lu , Wenju Wu , Jean Xu
IPC分类号： C07D473/32
摘要： Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
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10.发明授权公开(公告)号：US10398700B2
公开(公告)日：2019-09-03
申请号：US16169414
申请日：2018-10-24
发明人： Matthew Alexander , Joshua Hansen , Dehua Huang , Robert Hubbard , Raj K. Raheja , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , JingJing Zhao
IPC分类号： A61K31/52 , C07D473/32 , A61K31/5377 , A61P35/00
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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