专利检索 ap:("Signal Pharmaceuticals, LLC") AND inv:"Hon-Wah Man" 第 1 页

1.

发明授权
Isotopologues of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide 有权

公开(公告)号：US10975039B2

公开(公告)日：2021-04-13

申请号：US16871143

申请日：2020-05-11

申请人： Signal Pharmaceuticals, LLC

发明人： Hon-Wah Man , Mohit Atul Kothare

IPC分类号： C07D239/48 , C07B59/00

摘要： Provided herein are isotopologues of Compound A, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided.

2.

发明授权
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use 有权

公开(公告)号：US10517873B2

公开(公告)日：2019-12-31

申请号：US16266793

申请日：2019-02-04

申请人： Signal Pharmaceuticals, LLC

发明人： Marie Georges Beauchamps , Antonio Christian Ferretti , Robert Hilgraf , Mohit Atul Kothare , Hon-Wah Man , Mark A. Nagy , Kelvin Hin-Yeong Yong , Nanfei Zou

IPC分类号： C07D239/42 , A61K31/505 , C07D239/48

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

3.

发明申请
SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE 审中-公开

公开(公告)号：US20180028534A1

公开(公告)日：2018-02-01

申请号：US15727659

申请日：2017-10-09

申请人： Signal Pharmaceuticals, LLC

发明人： Hon-Wah Man , Marie Georges Beauchamps , Mohit Atul Kothare , Nanfei Zou

IPC分类号： A61K31/505 , C07D239/42 , C07D239/48

CPC分类号： A61K31/505 , C07D239/42 , C07D239/48

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

4.

发明授权
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use 有权
标题翻译：固体形式的2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺及其使用方法

公开(公告)号：US09365524B2

公开(公告)日：2016-06-14

申请号：US14608314

申请日：2015-01-29

申请人： Signal Pharmaceuticals, LLC

发明人： Hon-Wah Man , Jean Xu , Marie Georges Beauchamps , Mohit Atul Kothare , Nanfei Zou , Ying Li , Lianfeng Huang , Daozhong Zou

IPC分类号： A61K31/505 , C07D239/48 , C07D239/42

CPC分类号： A61K31/505 , C07D239/42 , C07D239/48

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

摘要翻译： 本文提供了与2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺相关的制剂，方法，固体形式和使用方法。

5.

发明授权
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use 有权

公开(公告)号：US11241430B2

公开(公告)日：2022-02-08

申请号：US16679592

申请日：2019-11-11

申请人： Signal Pharmaceuticals, LLC

发明人： Marie Georges Beauchamps , Robert Hilgraf , Mohit Atul Kothare , Hon-Wah Man , Mark A. Nagy

IPC分类号： A61K31/505 , C07D239/48 , C07D239/42

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

6.

发明申请
SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE 审中-公开

公开(公告)号：US20200078359A1

公开(公告)日：2020-03-12

申请号：US16679592

申请日：2019-11-11

申请人： Signal Pharmaceuticals, LLC

发明人： Marie Georges Beauchamps , Robert Hilgraf , Mohit Atul Kothare , Hon-Wah Man , Mark A. Nagy

IPC分类号： A61K31/505 , C07D239/42 , C07D239/48

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

7.

发明授权
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use 有权

公开(公告)号：US10226461B2

公开(公告)日：2019-03-12

申请号：US15727659

申请日：2017-10-09

申请人： Signal Pharmaceuticals, LLC

发明人： Hon-Wah Man , Marie Georges Beauchamps , Mohit Atul Kothare , Nanfei Zou

IPC分类号： C07D239/42 , A61K31/505 , C07D239/48

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

8.

发明授权
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use 有权

公开(公告)号：US09814713B2

公开(公告)日：2017-11-14

申请号：US15152653

申请日：2016-05-12

申请人： Signal Pharmaceuticals, LLC

发明人： Hon-Wah Man , Jean Xu , Marie Georges Beauchamps , Mohit Atul Kothare , Nanfei Zou , Ying Li , Lianfeng Huang , Daozhong Zou

IPC分类号： A61K31/505 , C07D239/48 , C07D239/42

CPC分类号： A61K31/505 , C07D239/42 , C07D239/48

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2 -(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

9.

发明申请
SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE 审中-公开

公开(公告)号：US20160256459A1

公开(公告)日：2016-09-08

申请号：US15152653

申请日：2016-05-12

申请人： Signal Pharmaceuticals, LLC

发明人： Hon-Wah Man , Jean Xu , Marie Georges Beauchamps , Mohit Atul Kothare , Nanfei Zou , Ying Li , Lianfeng Huang , Daozhong Zou

IPC分类号： A61K31/505

CPC分类号： A61K31/505 , C07D239/42 , C07D239/48

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

10.

发明申请
SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE 有权

公开(公告)号：US20220378785A1

公开(公告)日：2022-12-01

申请号：US17562933

申请日：2021-12-27

申请人： Signal Pharmaceuticals, LLC

发明人： Marie Georges Beauchamps , Robert Hilgraf , Mohit Atul Kothare , Hon-Wah Man , Mark A. Nagy

IPC分类号： A61K31/505 , C07D239/48 , C07D239/42

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.