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1.发明授权Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith 有权取代的二氨基嘧啶基化合物，其组合物及其处理方法公开(公告)号：US09556126B2
公开(公告)日：2017-01-31
申请号：US14576197
申请日：2014-12-19
发明人： Patrick Papa , Brian Edwin Cathers , Andrew Antony Calabrese , Brandon Wade Whitefield , Brydon Bennett , Daniel Cashion , Deborah Mortensen , Dehua Huang , Eduardo Torres , Jason Parnes , John Sapienza , Joshua Hansen , Katerina Leftheris , Matthew Correa , Maria Mercedes Delgado , Raj K. Raheja , Sogole Bahmanyar , Sayee Hegde , Stephen Norris , Veronique Plantevin-Krenitsky
IPC分类号： C07D403/12 , A61K31/505 , C07D239/48 , C07D401/12 , C07D409/12 , C07D413/12 , C07D405/12 , C07D471/04 , C07D405/14 , A61K31/506 , C07D417/12
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
摘要翻译： 本文提供具有以下结构的二氨基嘧啶化合物：其中X，L，R 1和R 2如本文所定义，包含有效量的二氨基嘧啶基化合物的组合物，以及用于治疗或预防PKC-θ介导的病症的方法或病症 可通过抑制激酶例如PKC-θ治疗或预防。
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2.发明授权Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith 有权取代的二氨基嘧啶基化合物，其组合物及其处理方法公开(公告)号：US09156798B2
公开(公告)日：2015-10-13
申请号：US14680530
申请日：2015-04-07
发明人： Sogole Bahmanyar , Andrew Antony Calabrese , Daniel Cashion , Brian Edwin Cathers , Matthew Correa , Maria Mercedes Delgado , Joshua Hansen , Sayee Hegde , Dehua Huang , Katerina Leftheris , Deborah Mortensen , Stephen Norris , Patrick Papa , Jason Parnes , Veronique Plantevin-Krenitsky , Raj Kumar Raheja , John Sapienza , Eduardo Torres , Brandon Wade Whitefield
IPC分类号： C07D403/12 , C07D239/48 , C07D401/12 , C07D409/12 , C07D413/12 , C07D405/12 , C07D471/04 , C07D405/14
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
摘要翻译： 本文提供具有以下结构的二氨基嘧啶化合物：其中X，L，R 1和R 2如本文所定义，包含有效量的二氨基嘧啶基化合物的组合物，以及用于治疗或预防PKC-θ介导的病症的方法或病症 可通过抑制激酶例如PKC-θ治疗或预防。
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3.发明授权公开(公告)号：US09783505B2
公开(公告)日：2017-10-10
申请号：US15241232
申请日：2016-08-19
发明人： Patrick Papa , Brian Edwin Cathers , Andrew Antony Calabrese , Brandon Wade Whitefield , Brydon Bennett , Daniel Cashion , Deborah Mortensen , Dehua Huang , Eduardo Torres , Jason Parnes , John Sapienza , Joshua Hansen , Katerina Leftheris , Matthew Correa , Maria Mercedes Delgado , Raj K. Raheja , Sogole Bahmanyar , Sayee Hegde , Stephen Norris , Veronique Plantevin-Krenitsky
IPC分类号： A61K31/505 , C07D239/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D405/12 , C07D471/04 , C07D405/14 , A61K31/506 , C07D417/12 , A61K31/5377
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
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