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1.发明公开公开(公告)号：US20230158035A1
公开(公告)日：2023-05-25
申请号：US18095670
申请日：2023-01-11
发明人： Matthew Alexander , Sogole Bahmanyar , John Frederick Boylan , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , Jingjing Zhao
IPC分类号： A61K31/52 , C07D473/32 , A61P35/00 , A61K31/5377
CPC分类号： A61K31/52 , C07D473/32 , A61P35/00 , A61K31/5377
摘要： Provided herein are Aminopurine Compounds having the following structures:
wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.-
2.发明授权公开(公告)号：US10940152B2
公开(公告)日：2021-03-09
申请号：US16846503
申请日：2020-04-13
发明人： Matthew Alexander , Sogole Bahmanyar , John Frederick Boylan , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , JingJing Zhao
IPC分类号： A61K31/52 , C07D473/32 , A61P35/00 , A61K31/5377
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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3.发明授权Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith 有权取代的氨基嘌呤化合物，其组合物及其处理方法公开(公告)号：US09512124B2
公开(公告)日：2016-12-06
申请号：US14874513
申请日：2015-10-05
发明人： Matthew Alexander , Sogole Bahmanyar , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , JingJing Zhao , John Frederick Boylan
IPC分类号： C07D473/32
CPC分类号： A61K31/52 , A61K31/5377 , A61P35/00 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物，以及用于治疗或预防癌症的方法，例如黑素瘤。
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4.发明授权公开(公告)号：US11590139B2
公开(公告)日：2023-02-28
申请号：US17147127
申请日：2021-01-12
发明人： Matthew Alexander , Sogole Bahmanyar , John Frederick Boylan , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , JingJing Zhao
IPC分类号： A61K31/52 , C07D473/32 , A61P35/00 , A61K31/5377
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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5.发明申请公开(公告)号：US20190091230A1
公开(公告)日：2019-03-28
申请号：US16169414
申请日：2018-10-24
发明人： Matthew Alexander , Joshua Hansen , Dehua Huang , Robert Hubbard , Raj K. Raheja , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , JingJing Zhao
IPC分类号： A61K31/52 , A61P35/00 , C07D473/32 , A61K31/5377
CPC分类号： A61K31/52 , A61K31/5377 , A61P35/00 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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6.发明授权公开(公告)号：US10149849B2
公开(公告)日：2018-12-11
申请号：US15641383
申请日：2017-07-05
发明人： Matthew Alexander , Joshua Hansen , Dehua Huang , Robert Hubbard , Raj K. Raheja , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , JingJing Zhao
IPC分类号： C07D473/32 , A61K31/52 , A61K31/5377 , A61P35/00
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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7.发明授权公开(公告)号：US09783505B2
公开(公告)日：2017-10-10
申请号：US15241232
申请日：2016-08-19
发明人： Patrick Papa , Brian Edwin Cathers , Andrew Antony Calabrese , Brandon Wade Whitefield , Brydon Bennett , Daniel Cashion , Deborah Mortensen , Dehua Huang , Eduardo Torres , Jason Parnes , John Sapienza , Joshua Hansen , Katerina Leftheris , Matthew Correa , Maria Mercedes Delgado , Raj K. Raheja , Sogole Bahmanyar , Sayee Hegde , Stephen Norris , Veronique Plantevin-Krenitsky
IPC分类号： A61K31/505 , C07D239/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D405/12 , C07D471/04 , C07D405/14 , A61K31/506 , C07D417/12 , A61K31/5377
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
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8.发明申请SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权取代的氨基嘌呤化合物，其组合物及其处理方法公开(公告)号：US20160096841A1
公开(公告)日：2016-04-07
申请号：US14874513
申请日：2015-10-05
发明人： Matthew Alexander , Sogole Bahmanyar , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , JingJing Zhao , John Frederick Boylan
IPC分类号： C07D473/32
CPC分类号： A61K31/52 , A61K31/5377 , A61P35/00 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物，以及用于治疗或预防癌症的方法，例如黑素瘤。
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9.发明申请公开(公告)号：US20210128565A1
公开(公告)日：2021-05-06
申请号：US17147127
申请日：2021-01-12
发明人： Matthew Alexander , Sogole Bahmanyar , John Frederick Boylan , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , JingJing Zhao
IPC分类号： A61K31/52 , C07D473/32 , A61P35/00 , A61K31/5377
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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10.发明申请公开(公告)号：US20200237768A1
公开(公告)日：2020-07-30
申请号：US16846503
申请日：2020-04-13
发明人： Matthew Alexander , Sogole Bahmanyar , John Frederick Boylan , Joshua Hansen , Dehua Huang , Robert Hubbard , Brandon Jeffy , Jim Leisten , Mehran Moghaddam , Raj K. Raheja , Heather Raymon , Kimberly Schwarz , Marianne Sloss , Eduardo Torres , Tam Minh Tran , Shuichan Xu , JingJing Zhao
IPC分类号： A61K31/52 , A61K31/5377 , A61P35/00 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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