公开(公告)号：US20150175557A1

公开(公告)日：2015-06-25

申请号：US14576197

申请日：2014-12-19

申请人： Signal Pharmaceuticals, LLC

发明人： Patrick Papa ,  Brian Edwin Cathers ,  Andrew Antony CALABRESE ,  Brandon Wade WHITEFIELD ,  Brydon BENNETT ,  Daniel CASHION ,  Deborah MORTENSEN ,  Dehua HUANG ,  Eduardo TORRES ,  Jason PARNES ,  John SAPIENZA ,  Joshua HANSEN ,  Katerina LEFTHERIS ,  Matthew CORREA ,  Maria Mercedes DELGADO ,  Neil RAHEJA ,  Sami BAHMANYAR ,  Sayee HEGDE ,  Stephen NORRIS ,  Veronique PLANTEVIN-KRENITSKY

IPC分类号： C07D239/48 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D405/12 ,  C07D471/04 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.