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![PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY](/abs-image/US/2016/01/28/US20160024101A1/abs.jpg.150x150.jpg)
1.发明申请公开(公告)号：US20160024101A1
公开(公告)日：2016-01-28
申请号：US14874524
申请日：2015-10-05
发明人： Jan ELSNER , Kimberly Elizabeth FULTZ , Roy L. HARRIS , Branden Gingsee LEE , Loui MADAKAMUTIL , Deborah MORTENSEN , Rama K. NARLA , Garrick K. PACKARD , Patrick PAPA , Jason PARNES , Sophie PERRIN-NINKOVIC , Jennifer RIGGS , Sabita SANKAR , John SAPIENZA , Graziella I. SHEVLIN , Lida TEHRANI , Weiming XU , Jingjing ZHAO
IPC分类号： C07D487/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14 , C07D471/04
CPC分类号： C07D487/04 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
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![PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY](/abs-image/US/2020/08/20/US20200262840A1/abs.jpg.150x150.jpg)
2.发明申请公开(公告)号：US20200262840A1
公开(公告)日：2020-08-20
申请号：US16865512
申请日：2020-05-04
发明人： Jan ELSNER , Roy L. HARRIS , Branden Gingsee LEE , Deborah MORTENSEN , Garrick K. PACKARD , Patrick PAPA , Jason PARNES , Sophie PERRIN-NINKOVIC , Jennifer RIGGS , John SAPIENZA , Graziella I. SHEVLIN , Lida TEHRANI , Jingjing ZHAO
IPC分类号： C07D487/04 , C07D487/14 , C07D487/10 , C07D471/14 , C07D471/04 , C07D241/20 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
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3.发明申请SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权取代的二氨基吡啶化合物，其组合物及其处理方法公开(公告)号：US20150246890A1
公开(公告)日：2015-09-03
申请号：US14680530
申请日：2015-04-07
发明人： Sogole BAHMANYAR , Andrew Antony CALABRESE , Daniel CASHION , Brian Edwin CATHERS , Matthew CORREA , Maria Mercedes DELGADO , Joshua HANSEN , Sayee HEGDE , Dehua HUANG , Katerina LEFTHERIS , Deborah MORTENSEN , Stephen NORRIS , Patrick PAPA , Jason PARNES , Veronique PLANTEVIN-KRENITSKY , Raj Kumar RAHEJA , John SAPIENZA , Eduardo TORRES , Brandon Wade WHITEFIELD
IPC分类号： C07D239/48 , C07D403/12 , C07D405/14 , C07D413/12 , C07D405/12 , C07D471/04 , C07D401/12 , C07D409/12
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
摘要翻译： 本文提供具有以下结构的二氨基嘧啶化合物：其中X，L，R 1和R 2如本文所定义，包含有效量的二氨基嘧啶基化合物的组合物，以及用于治疗或预防PKC-θ介导的病症的方法或病症 可通过抑制激酶例如PKC-θ治疗或预防。
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![PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY](/abs-image/US/2019/03/14/US20190077806A1/abs.jpg.150x150.jpg)
4.发明申请公开(公告)号：US20190077806A1
公开(公告)日：2019-03-14
申请号：US16186883
申请日：2018-11-12
发明人： Jan ELSNER , Roy L. HARRIS , Branden Gingsee LEE , Deborah MORTENSEN , Garrick K. PACKARD , Patrick PAPA , Jason PARNES , Sophie PERRIN-NINKOVIC , Jennifer RIGGS , John SAPIENZA , Graziella I. SHEVLIN , Lida TEHRANI , Jingjing ZHAO
IPC分类号： C07D487/04 , C07D241/20 , C07D487/14 , C07D498/14 , C07D471/14 , C07D471/04 , C07D487/10
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
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![PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY](/abs-image/US/2017/11/30/US20170342080A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20170342080A1
公开(公告)日：2017-11-30
申请号：US15680688
申请日：2017-08-18
发明人： Jan ELSNER , Roy L. HARRIS , Branden Gingsee LEE , Deborah MORTENSEN , Garrick K. PACKARD , Patrick PAPA , Jason PARNES , Sophie PERRIN-NINKOVIC , Jennifer RIGGS , John SAPIENZA , Graziella I. SHEVLIN , Lida TEHRANI , Jingjing ZHAO
IPC分类号： C07D487/04 , C07D487/14 , C07D487/10 , C07D471/14 , C07D471/04 , C07D498/14 , C07D241/20
CPC分类号： C07D487/04 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
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6.发明申请公开(公告)号：US20160354374A1
公开(公告)日：2016-12-08
申请号：US15241232
申请日：2016-08-19
发明人： Patrick Papa , Brian Edwin Cathers , Andrew Antony CALABRESE , Brandon Wade WHITEFIELD , Brydon BENNETT , Daniel CASHION , Deborah MORTENSEN , Dehua HUANG , Eduardo TORRES , Jason PARNES , John SAPIENZA , Joshua HANSEN , Katerina LEFTHERIS , Matthew CORREA , Maria Mercedes DELGADO , Raj K. RAHEJA , Sogole BAHMANYAR , Sayee HEGDE , Stephen NORRIS , Veronique PLANTEVIN-KRENITSKY
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/505
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
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7.发明申请公开(公告)号：US20150175557A1
公开(公告)日：2015-06-25
申请号：US14576197
申请日：2014-12-19
发明人： Patrick Papa , Brian Edwin Cathers , Andrew Antony CALABRESE , Brandon Wade WHITEFIELD , Brydon BENNETT , Daniel CASHION , Deborah MORTENSEN , Dehua HUANG , Eduardo TORRES , Jason PARNES , John SAPIENZA , Joshua HANSEN , Katerina LEFTHERIS , Matthew CORREA , Maria Mercedes DELGADO , Neil RAHEJA , Sami BAHMANYAR , Sayee HEGDE , Stephen NORRIS , Veronique PLANTEVIN-KRENITSKY
IPC分类号： C07D239/48 , C07D403/12 , C07D405/14 , C07D413/12 , C07D405/12 , C07D471/04 , C07D401/12 , C07D409/12
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
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