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1.发明申请公开(公告)号：US20120142707A1
公开(公告)日：2012-06-07
申请号：US13151706
申请日：2011-06-02
申请人： Alicia Regueiro-Ren , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen
发明人： Alicia Regueiro-Ren , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen
IPC分类号： A61K31/235 , C07C63/66 , C07D257/04 , C07D215/50 , C07D333/40 , C07D213/64 , C07D239/28 , A61K31/194 , A61K31/196 , A61K31/41 , A61K31/47 , A61K31/381 , A61K31/4418 , A61K31/505 , A61P31/12 , A61P31/18 , A61P37/02 , C07C309/65 , C07C69/753
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 betulinic acid and other structurally related natural products derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的改良的C-3桦木酸和其他与结构相关的天然产物衍生物作为HIV成熟抑制剂提供。 这些化合物可用于治疗艾滋病毒和艾滋病。
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2.发明申请C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS 有权C-28作为HIV成熟抑制剂的改性C-3白蛋白酸衍生物公开(公告)号：US20120142653A1
公开(公告)日：2012-06-07
申请号：US13151722
申请日：2011-06-02
申请人： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen , Yan Chen , Ny Sin
发明人： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen , Yan Chen , Ny Sin
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的改良的C-3和C-28桦木酸衍生物作为HIV成熟抑制剂提供。 这些化合物可用于治疗艾滋病毒和艾滋病。
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3.发明授权C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity 有权C-17和C-3修饰的三萜类化合物具有HIV成熟抑制活性公开(公告)号：US08846647B2
公开(公告)日：2014-09-30
申请号：US13359727
申请日：2012-01-27
申请人： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
发明人： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
CPC分类号： A61K31/565 , A61K31/56 , A61K31/58 , A61K31/704 , A61K45/06 , C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的C-17和C-3修饰的三萜类化合物作为HIV成熟抑制剂提供，如式I，II和III化合物所示：这些化合物可用于治疗HIV和AIDS。
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4.发明授权
公开(公告)号：US5892045A
公开(公告)日：1999-04-06
申请号：US972280
申请日：1997-11-18
IPC分类号： C07D215/22 , A61K31/47 , A61P1/04 , A61P9/10 , A61P11/06 , A61P21/02 , A61P25/00 , A61P25/06 , A61P43/00 , C07D215/227 , C07D215/16 , C07D215/20 , C07D215/36
CPC分类号： C07D215/227 , Y10S514/826
摘要： There is provided novel substituted 4-aryl-3-hydroxyquinolin-2-one derivatives of the formula ##STR1## wherein R is hydrogen or methyl;R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are independently hydrogen, bromo, chloro or trifluoromethyl, and when R.sup.1, R.sup.3 and R.sup.4 are hydrogen, R.sup.2 is nitro;R.sup.5 is hydrogen or methyl; andR.sup.6 is bromo or chloro;or a nontoxic pharmaceutically acceptable salt thereof, which are openers of the large-conductance calcium-activated potassium channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.
摘要翻译： 提供了新颖的式“IMAGE”的取代的4-芳基-3-羟基喹啉-2-酮衍生物，其中R是氢或甲基; R 1，R 2，R 3和R 4各自独立地为氢，溴，氯或三氟甲基，当R 1，R 3和R 4为氢时，R 2为硝基; R5是氢或甲基; 并且R 6是溴或氯; 或其无毒的药学上可接受的盐，其是大电导钙激活的钾通道的开放剂，并且可用于治疗对钾通道开放有反应的病症。
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5.发明授权C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors 有权改性C-3桦木酸衍生物的C-28酰胺作为HIV成熟抑制剂公开(公告)号：US08802661B2
公开(公告)日：2014-08-12
申请号：US13151722
申请日：2011-06-02
申请人： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen , Yan Chen , Ny Sin
发明人： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen , Yan Chen , Ny Sin
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的改良的C-3和C-28桦木酸衍生物作为HIV成熟抑制剂提供。 这些化合物可用于治疗艾滋病毒和艾滋病。
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6.发明申请C-28 AMINES OF C-3 MODIFIED BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS 有权作为HIV成熟抑制剂的C-28修饰的乳清酸衍生物的C-28氨基酸公开(公告)号：US20130029954A1
公开(公告)日：2013-01-31
申请号：US13359680
申请日：2012-01-27
申请人： Alicia Regueiro-Ren , Jacob Swidorski , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell , Zheng Liu
发明人： Alicia Regueiro-Ren , Jacob Swidorski , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell , Zheng Liu
IPC分类号： A61K31/565 , A61P31/18 , A61P31/14 , C07J53/00 , A61K31/58
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof:a compound of formula I a compound of formula II and a compound of formula III
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的C-3修饰的桦木酸衍生物的C-28胺被提供为HIV成熟抑制剂。 这些化合物可用于治疗艾滋病毒和艾滋病。 特别地，本文提供以下化合物，包括其药学上可接受的盐：式I化合物式II化合物和式III化合物
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7.发明授权
公开(公告)号：US5922735A
公开(公告)日：1999-07-13
申请号：US166273
申请日：1998-10-05
IPC分类号： C07D215/22 , A61K31/47 , A61P1/04 , A61P9/10 , A61P11/06 , A61P21/02 , A61P25/00 , A61P25/06 , A61P43/00 , C07D215/227 , A61K31/55
CPC分类号： C07D215/227 , Y10S514/826
摘要： There is provided novel substituted 4-aryl-3-hydroxyquinolin-2-one derivatives of the formula ##STR1## wherein R is hydrogen or methyl;R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are independently hydrogen, bromo, chloro or trifluoromethyl, and when R.sup.1, R.sup.3 and R.sup.4 are hydrogen, R.sup.2 is nitro;R.sup.5 is hydrogen or methyl; andR.sup.6 is bromo or chloro;or a nontoxic pharmaceutically acceptable salt thereof, which are openers of the large-conductance calcium-activated potassium channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.
摘要翻译： 提供下式的新的取代的4-芳基-3-羟基喹啉-2-酮衍生物其中R是氢或甲基; R 1，R 2，R 3和R 4各自独立地为氢，溴，氯或三氟甲基，当R 1，R 3和R 4为氢时，R 2为硝基; R5是氢或甲基; 并且R 6是溴或氯; 或其无毒的药学上可接受的盐，其是大电导钙激活的钾通道的开放剂，并且可用于治疗对钾通道开放有反应的病症。
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8.发明授权公开(公告)号：US08754068B2
公开(公告)日：2014-06-17
申请号：US13151706
申请日：2011-06-02
申请人： Alicia Regueiro-Ren , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen , Ny Sin
发明人： Alicia Regueiro-Ren , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen , Ny Sin
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 betulinic acid and other structurally related natural products derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的改良的C-3桦木酸和其他与结构相关的天然产物衍生物作为HIV成熟抑制剂提供。 这些化合物可用于治疗艾滋病毒和艾滋病。
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9.发明授权C-28 amines of C-3 modified betulinic acid derivatives as HIV maturation inhibitors 有权C-28修饰的桦木酸衍生物的C-28胺作为HIV成熟抑制剂公开(公告)号：US08748415B2
公开(公告)日：2014-06-10
申请号：US13359680
申请日：2012-01-27
申请人： Alicia Regueiro-Ren , Jacob Swidorski , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell , Zheng Liu
发明人： Alicia Regueiro-Ren , Jacob Swidorski , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell , Zheng Liu
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof:a compound of formula I a compound of formula II and a compound of formula III
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的C-3修饰的桦木酸衍生物的C-28胺被提供为HIV成熟抑制剂。 这些化合物可用于治疗艾滋病毒和艾滋病。 特别地，本文提供以下化合物，包括其药学上可接受的盐：式I化合物式II化合物和式III化合物
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10.发明申请C-17 AND C-3 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY 有权C-17和C-3修饰的TRAILRPENOIDS与HIV成熟抑制活性公开(公告)号：US20130035318A1
公开(公告)日：2013-02-07
申请号：US13359727
申请日：2012-01-27
申请人： ALICIA REGUEIRO-REN , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
发明人： ALICIA REGUEIRO-REN , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
IPC分类号： C07J53/00 , A61K31/58 , A61P31/18 , A61K31/565
CPC分类号： A61K31/565 , A61K31/56 , A61K31/58 , A61K31/704 , A61K45/06 , C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的C-17和C-3修饰的三萜类化合物作为HIV成熟抑制剂提供，如式I，II和III化合物所示：这些化合物可用于治疗HIV和AIDS。
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