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1.发明授权公开(公告)号：US11932854B2
公开(公告)日：2024-03-19
申请号：US17510277
申请日：2021-10-25
发明人： Mark Cancilla , James John Cunningham , William Michael Flanagan , Henry J. Haringsma , Denise M. Kenski , Matthew G. Stanton , Steven M. Stirdivant , Aarron T. Willingham
IPC分类号： C07H21/02 , A61K31/713 , C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/331 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2320/32 , C12N2320/51 , C12N2310/321 , C12N2310/3527 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
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2.发明申请公开(公告)号：US20220195433A1
公开(公告)日：2022-06-23
申请号：US17510277
申请日：2021-10-25
发明人： Mark Cancilla , James John Cunningham , William Michael Flanagan , Henry J. Haringsma , Denise M. Kenski , Matthew G. Stanton , Steven M. Stirdivant , Aarron T. Willingham
IPC分类号： C12N15/113 , C12N15/11 , A61K31/713 , C07H21/02
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (MAO against target gene expression.
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3.发明授权公开(公告)号：US11193126B2
公开(公告)日：2021-12-07
申请号：US15947248
申请日：2018-04-06
发明人： Mark Cancilla , James John Cunningham , William Michael Flanagan , Henry J. Haringsma , Denise M. Kenski , Matthew G. Stanton , Steven M. Stirdivant , Aarron T. Willingham
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , C12N15/11 , A61K31/713
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
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4.发明申请公开(公告)号：US20180362977A1
公开(公告)日：2018-12-20
申请号：US15947248
申请日：2018-04-06
发明人： Mark Cancilla , James John Cunningham , William Michael Flanagan , Henry J. Haringsma , Denise M. Kenski , Matthew G. Stanton , Steven M. Stirdivant , Aarron T. Willingham
IPC分类号： C12N15/113 , C07H21/02 , C12N15/11
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
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5.发明授权公开(公告)号：US09970005B2
公开(公告)日：2018-05-15
申请号：US14984065
申请日：2015-12-30
发明人： Mark Cancilla , James John Cunningham , William Michael Flanagan , Henry J. Haringsma , Denise M. Kenski , Matthew G. Stanton , Steven M. Stirdivant , Aarron T. Willingham
IPC分类号： C07H21/02 , C12N15/113 , C12N15/11
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/331 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2320/32 , C12N2320/51 , C12N2310/3527 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
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6.发明申请公开(公告)号：US20160264964A1
公开(公告)日：2016-09-15
申请号：US14984065
申请日：2015-12-30
发明人： Mark Cancilla , James John Cunningham , Michael William Flanagan , Henry J. Haringsma , Denise M. Kenski , Matthew G. Stanton , Steven M. Stirdivant , Aarron T. Willingham
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/331 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2320/32 , C12N2320/51 , C12N2310/3527 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
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