公开(公告)号：US20100310593A1

公开(公告)日：2010-12-09

申请号：US12664554

申请日：2008-06-16

申请人： So-ching Brazer ,  James Adam Crawford ,  Chunghee Lee ,  Sukjoon Park ,  W. James Jackson ,  Michael Joseph Lacy ,  Hang Lu

发明人： So-ching Brazer ,  James Adam Crawford ,  Chunghee Lee ,  Sukjoon Park ,  W. James Jackson ,  Michael Joseph Lacy ,  Hang Lu

IPC分类号： A61K39/02 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C07K14/295 ,  A61K48/00 ,  A61K38/16 ,  A61P31/04

CPC分类号： A61K39/118 ,  Y02A50/484

摘要： The present invention is directed to providing a vaccine to enhance the immune response of an animal in need of protection against a Chlamydia infection. The present invention is also directed toward an isolated nucleic acid encoding a polypeptide comprising at least 70% identity to any one of SEQ ID NOS: 2, 11, 13, 19, or 21, wherein the polypeptide is soluble in the absence of denaturing agents. In some aspects of the invention, the polynucleotide is codon-optimized. In some embodiments, the present invention is related to the polypeptide encoded by the polynucleotide of the invention. Administration of polypeptides of the present invention can be used as a method to treat or prevent a Chlamydia infection in an animal in need thereof.

摘要翻译： 本发明旨在提供一种用于增强需要防止衣原体感染的动物的免疫应答的疫苗。 本发明还涉及编码与SEQ ID NO：2,11,13,19或21中任一个具有至少70％同一性的多肽的分离的核酸，其中所述多肽在不存在变性剂的情况下是可溶的 。 在本发明的一些方面，多核苷酸是密码子优化的。 在一些实施方案中，本发明涉及由本发明的多核苷酸编码的多肽。 本发明的多肽的施用可以用作在有需要的动物中治疗或预防衣原体感染的方法。