公开(公告)号：US20160083796A1

公开(公告)日：2016-03-24

申请号：US14888994

申请日：2014-05-05

申请人： Sofia MIKKO ,  Leif ANDERSSON ,  Gabriella LINDGREN ,  Carl-Johan RUBIN ,  Bhanu CHOWDHARY ,  Terje RAUDSEPP ,  Evans E. EICHLER ,  John HUDDLESTON ,  Maika MALIG

发明人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to methods for detecting a genetic deletion at the SHOX locus of a horse, where the presence of such a genetic deletion indicates that the horse is a carrier of disease-causing mutation that can lead to skeletal atavism. The invention further provides nucleic acid primers and probes for use in methods for detecting the presence or absence of disease-causing genetic deletion at the SHOX locus of a horse.

摘要翻译： 本发明涉及用于检测马的SHOX基因座上的遗传缺失的方法，其中存在这样的遗传缺失表明该马是导致骨骼萎缩的致病突变的载体。 本发明还提供了用于检测马的SHOX基因座上存在或不存在致病遗传缺失的方法的核酸引物和探针。

公开(公告)号：US20180282812A1

公开(公告)日：2018-10-04

申请号：US16004537

申请日：2018-06-11

申请人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

发明人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

IPC分类号： C12Q1/6883

摘要： The present invention relates to methods for detecting a genetic deletion at the SHOX locus of a horse, where the presence of such a genetic deletion indicates that the horse is a carrier of disease-causing mutation that can lead to skeletal atavism. The invention further provides nucleic acid primers and probes for use in methods for detecting the presence or absence of disease-causing genetic deletion at the SHOX locus of a horse.

公开(公告)号：US11286527B2

公开(公告)日：2022-03-29

申请号：US16004537

申请日：2018-06-11

申请人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

发明人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

IPC分类号： C07H21/04 ,  C12Q1/68 ,  A01K67/00 ,  C12Q1/6883

摘要： The present invention relates to methods for detecting a genetic deletion at the SHOX locus of a horse, where the presence of such a genetic deletion indicates that the horse is a carrier of disease-causing mutation that can lead to skeletal atavism. The invention further provides nucleic acid primers and probes for use in methods for detecting the presence or absence of disease-causing genetic deletion at the SHOX locus of a horse.