公开(公告)号：US11286527B2

公开(公告)日：2022-03-29

申请号：US16004537

申请日：2018-06-11

申请人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

发明人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

IPC分类号： C07H21/04 ,  C12Q1/68 ,  A01K67/00 ,  C12Q1/6883

摘要： The present invention relates to methods for detecting a genetic deletion at the SHOX locus of a horse, where the presence of such a genetic deletion indicates that the horse is a carrier of disease-causing mutation that can lead to skeletal atavism. The invention further provides nucleic acid primers and probes for use in methods for detecting the presence or absence of disease-causing genetic deletion at the SHOX locus of a horse.

公开(公告)号：US10378057B2

公开(公告)日：2019-08-13

申请号：US15682124

申请日：2017-08-21

申请人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

发明人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q1/6876 ,  G01N33/68 ,  C12Q1/6881 ,  A01K29/00

摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

公开(公告)号：US20160083796A1

公开(公告)日：2016-03-24

申请号：US14888994

申请日：2014-05-05

申请人： Sofia MIKKO ,  Leif ANDERSSON ,  Gabriella LINDGREN ,  Carl-Johan RUBIN ,  Bhanu CHOWDHARY ,  Terje RAUDSEPP ,  Evans E. EICHLER ,  John HUDDLESTON ,  Maika MALIG

发明人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to methods for detecting a genetic deletion at the SHOX locus of a horse, where the presence of such a genetic deletion indicates that the horse is a carrier of disease-causing mutation that can lead to skeletal atavism. The invention further provides nucleic acid primers and probes for use in methods for detecting the presence or absence of disease-causing genetic deletion at the SHOX locus of a horse.

摘要翻译： 本发明涉及用于检测马的SHOX基因座上的遗传缺失的方法，其中存在这样的遗传缺失表明该马是导致骨骼萎缩的致病突变的载体。 本发明还提供了用于检测马的SHOX基因座上存在或不存在致病遗传缺失的方法的核酸引物和探针。

公开(公告)号：US20150376705A1

公开(公告)日：2015-12-31

申请号：US14795415

申请日：2015-07-09

申请人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

发明人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

IPC分类号： C12Q1/68 ,  G01N33/68 ,  A01K29/00

CPC分类号： C12Q1/6883 ,  A01K29/00 ,  C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/124 ,  C12Q2600/156 ,  G01N33/6872 ,  G01N33/6875 ,  G01N2333/4703

摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

公开(公告)号：US20170356047A1

公开(公告)日：2017-12-14

申请号：US15682124

申请日：2017-08-21

申请人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

发明人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

IPC分类号： C12Q1/68 ,  A01K29/00 ,  G01N33/68

CPC分类号： C12Q1/6883 ,  A01K29/00 ,  C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/156 ,  G01N33/6872 ,  G01N33/6875 ,  G01N2333/4703

摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

公开(公告)号：US20190382843A1

公开(公告)日：2019-12-19

申请号：US16447027

申请日：2019-06-20

申请人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

发明人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

IPC分类号： C12Q1/6883 ,  C12Q1/6876 ,  G01N33/68 ,  A01K29/00 ,  C12Q1/6881

摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

公开(公告)号：US20220056530A1

公开(公告)日：2022-02-24

申请号：US17523482

申请日：2021-11-10

申请人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

发明人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

IPC分类号： C12Q1/6883 ,  C12Q1/6876 ,  G01N33/68 ,  A01K29/00 ,  C12Q1/6881

摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

公开(公告)号：US20240043926A1

公开(公告)日：2024-02-08

申请号：US18551126

申请日：2022-03-18

申请人： Gabriella LINDGREN ,  Maria ROSENGREN ,  Susanne ERIKSSON ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Gabriella LINDGREN ,  Maria ROSENGREN ,  Susanne ERIKSSON ,  Marina SOLÉ BERGA, ,  Rebecca BELLONE

IPC分类号： C12Q1/6876

CPC分类号： C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/156

摘要： The invention relates to a method for determining, in a sample comprising nucleic acid molecules obtained from the horse, presence or absence of at least one biomarker useful in predicting conformation of back and croup and/or gait quality and/or gait type trot or pace of the horse. The at least one biomarker is located in a region of from nucleotide position 44,000,000 to nucleotide position 47,000,000 on Equus caballus chromosome 22 (ECA22).

公开(公告)号：US20180282812A1

公开(公告)日：2018-10-04

申请号：US16004537

申请日：2018-06-11

申请人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

发明人： Sofia Mikko ,  Leif Andersson ,  Gabriella Lindgren ,  Carl-Johan Rubin ,  Bhanu Chowdhary ,  Terje Raudsepp ,  Evan E. Eichler ,  John Huddleston ,  Maika Malig

IPC分类号： C12Q1/6883

摘要： The present invention relates to methods for detecting a genetic deletion at the SHOX locus of a horse, where the presence of such a genetic deletion indicates that the horse is a carrier of disease-causing mutation that can lead to skeletal atavism. The invention further provides nucleic acid primers and probes for use in methods for detecting the presence or absence of disease-causing genetic deletion at the SHOX locus of a horse.

公开(公告)号：US20150044681A1

公开(公告)日：2015-02-12

申请号：US14467594

申请日：2014-08-25

申请人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

发明人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  A01K29/00 ,  C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/124 ,  C12Q2600/156 ,  G01N33/6872 ,  G01N33/6875 ,  G01N2333/4703

摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

摘要翻译： 本发明提供了一种用于预测马中运动模式的方法，其中包括马匹使用不同步态的能力和快速跑步的能力。 所述方法包括在样品中确定从马获得的DNA是否存在至少一种遗传标记，其中所述至少一种遗传标记位于马染色体23上，所述标记与使用不同步态的能力相关联。 本发明还提供了扩增与使用不同步态和杂交探针的能力相关联的标记的引物，以检测与使用不同步态的能力相关联的标记和以快速速度跑步的能力。