公开(公告)号：US20220133678A1

公开(公告)日：2022-05-05

申请号：US17541847

申请日：2021-12-03

Applicant: Sol-Gel Technologies Ltd.

Inventor： Moshe ARKIN ,  Karine NEIMANN ,  Ofer TOLEDANO

IPC: A61K31/327 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61P17/00 ,  A61K9/50 ,  A61K9/10

Abstract: A regimen is described for the therapeutic treatment of rosacea. The regimen includes topically applying a pharmaceutical composition to the skin of a subject in need of said treatment. The pharmaceutical composition includes from about 2.5% to about 10% benzoyl peroxide as the only active ingredient, and a pharmaceutically acceptable carrier or excipient. The regimen achieves, in a group of such subjects, a primary measure of success of at least about 9%, at least about 25%, at least about 40%, or at least about 47%, after application of said pharmaceutical composition once daily for at least about 2 weeks, at least about 4 weeks, at least about 8 weeks, or at least about 12 weeks, respectively.

公开(公告)号：US20210236416A1

公开(公告)日：2021-08-05

申请号：US17166164

申请日：2021-02-03

Applicant: Sol-Gel Technologies Ltd.

Inventor： Moshe ARKIN ,  Marcel ZIGHELBOIM ,  Karine NEIMANN

IPC: A61K9/00 ,  A61K31/4436 ,  A61K31/327 ,  A61K9/06 ,  A61K9/48

Abstract: Provided herein is a topical combination composition comprising roflumilast, roflumilast N-oxide or pharmaceutically acceptable salt thereof, and at least one additional active agent selected from a retinoid, benzoyl peroxide (BPO) and combinations thereof. The active agents in the composition of this invention are in encapsulated or non-encapsulated form, according to need.
The above composition is useful for the treatment, prevention or alleviation of a skin disorder selected from acne and rosacea and exhibits synergistic and/or additive effects allowing to reduce the active agents amounts in the topical combination compositions.

公开(公告)号：US20220142944A1

公开(公告)日：2022-05-12

申请号：US17582273

申请日：2022-01-24

Applicant: Sol-Gel Technologies Ltd.

Inventor： Moshe ARKIN ,  Marcel ZIGHELBOIM ,  Ori NOV ,  Ofer TOLEDANO ,  Karine NEIMANN ,  Hila HAKAK DJERBI

IPC: A61K31/05 ,  A61K47/18

Abstract: Disclosed are topical compositions and methods of treatment of a skin or mucosal disorder selected from palmoplantar psoriasis, hereditary palmoplantar keratoderma, acquired palmoplantar keratoderma, hydradenitis suppurativa, dermatitis, ichthyosis vulgaris, hereditary ichthyosis, acquired ichthyosis, actinic keratosis, a keratinization skin disorder, a keratinization mucosal disorder, Gorlin syndrome, nail psoriasis, flexural/inverse psoriasis, non-melanoma skin cancer, Cutaneous T-cell lymphoma and precancerous skin, mucosal and nail lesions, by once or twice daily topical administration to a subject of a composition comprising therapeutically effective amount of tapinarof.

公开(公告)号：US20210361608A1

公开(公告)日：2021-11-25

申请号：US17327729

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer TOLEDANO ,  Karine NEIMANN ,  Danil FINKEL-MOISEEV ,  Maya ERLICH ,  Dorit MARCO

IPC: A61K31/202 ,  A61K9/50 ,  A61K9/00 ,  A61K31/327

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20180235924A1

公开(公告)日：2018-08-23

申请号：US15753397

申请日：2016-08-17

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer TOLEDANO ,  Alon SERI-LEVY ,  Karine NEIMANN ,  Ori NOV

IPC: A61K31/327 ,  A61K9/00 ,  A61K9/16 ,  A61P17/06 ,  A61P17/04 ,  A61P17/10

CPC classification number: A61K31/327 ,  A61K9/0014 ,  A61K9/16 ,  A61K9/501 ,  A61K9/5089 ,  A61K31/192 ,  A61K2300/00 ,  A61P17/04 ,  A61P17/06 ,  A61P17/10

Abstract: The invention provides compositions comprising as active agents benzoyl peroxide (BPO), adapalene and optionally clindamycin phosphate, kits and uses thereof in methods for treating skin surface condition in a subject in need thereof.

公开(公告)号：US20230390291A1

公开(公告)日：2023-12-07

申请号：US18453355

申请日：2023-08-22

Applicant: Sol-Gel Technologies Ltd.

Inventor： Moshe ARKIN ,  Marcel ZIGHELBOIM ,  Ori NOV ,  Ofer TOLEDANO ,  Karine NEIMANN

IPC: A61K31/517 ,  A61P35/00 ,  A61K9/00

CPC classification number: A61K31/517 ,  A61P35/00 ,  A61K9/0014

Abstract: Provided herein compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib. The compositions of this invention are useful for the treatment, prevention or amelioration of skin or mucosal disorders like psoriasis, palmoplantar psoriasis, acquired palmoplantar keratosis, eczema, ichthyosis vulgaris, non-melanoma skin cancer, actinic keratosis, a keratinization skin disorder, a keratinization mucosal disorder, pachyonychia congenita, hidradenitis suppurativa, Gorlin syndrome, prurigo nodularis and prurigo pigmentosa.

公开(公告)号：US20210361583A1

公开(公告)日：2021-11-25

申请号：US17327732

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer TOLEDANO ,  Karine NEIMANN ,  Danil FINKEL-MOISEEV ,  Maya ERLICH ,  Dorit MARCO

IPC: A61K9/48 ,  A61K31/202 ,  A61K9/50 ,  A61K31/235 ,  A61K31/336 ,  A61K9/00

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20210346279A1

公开(公告)日：2021-11-11

申请号：US17313136

申请日：2021-05-06

Applicant: Sol-Gel Technologies Ltd.

Inventor： Marcel ZIGHELBOIM ,  Moshe ARKIN ,  Karine NEIMANN ,  Hila HAKAK DJERBI

IPC: A61K9/00 ,  A61K31/05 ,  A61K31/517 ,  A61P17/04 ,  A61K9/06

Abstract: The present invention, in some embodiments thereof, relates to a topical composition for use in treating, preventing, alleviating and/or ameliorating pruritus, wherein the composition comprises tapinarof and the pruritus is not associated with atopic dermatitis, psoriasis or any combination thereof.

公开(公告)号：US20230338306A1

公开(公告)日：2023-10-26

申请号：US18128328

申请日：2023-03-30

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer TOLEDANO ,  Karine NEIMANN ,  Danil FINKEL-MOISEEV ,  Maya ERLICH ,  Dorit MARCO

IPC: A61K31/07 ,  A61K31/327 ,  A61K9/50

CPC classification number: A61K31/07 ,  A61K9/501 ,  A61K9/5089 ,  A61K31/327

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20210346380A1

公开(公告)日：2021-11-11

申请号：US17352322

申请日：2021-06-20

Applicant: Sol-Gel Technologies Ltd.

Inventor： Moshe ARKIN ,  Marcel ZIGHELBOIM ,  Ori NOV ,  Ofer TOLEDANO ,  Karine NEIMANN ,  Asher Cachlon

IPC: A61K31/517 ,  A61K9/00 ,  A61K45/06

Abstract: This invention relates to compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib. The compositions of this invention are useful for the treatment, prevention or amelioration of skin or mucosal disorders like psoriasis, palmoplantar psoriasis, acquired palmoplantar keratosis, eczema, ichtyosis vulgaris, non-melanoma skin cancer, actinic keratosis, a keratinization skin disorder, a keratinization mucosal disorder, pachyonychia congenita, hidradenitis suppurativa, Gorlin syndrome, prurigo nodularis and prurigo pigmentosa.