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    METHOD FOR TREATMENT OF MODERATE TO SEVERE ERYTHEMA SYMPTOMS IN ROSACEA PATIENTS
    3.
    发明申请
    METHOD FOR TREATMENT OF MODERATE TO SEVERE ERYTHEMA SYMPTOMS IN ROSACEA PATIENTS 审中-公开

    公开(公告)号：US20200261402A1

    公开(公告)日：2020-08-20

    申请号：US16794974

    申请日：2020-02-19

    Applicant: Sol-Gel Technologies Ltd.

    Inventor： Ofer TOLEDANO ,  Ofra LEVY-HACHAM ,  Ori NOV ,  Vered RAM

    IPC: A61K31/327 ,  A61P17/00

    Abstract: A regimen for the therapeutic treatment of moderate to severe erythema symptoms in rosacea patients, the regimen comprising topically applying to the skin of a subject in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 12 weeks, to achieve a percentage decrease of about 60% in a population exhibiting moderate to severe erythema symptoms when measured at about 12 weeks after initial treatment of the population with the pharmaceutical composition.

    METHOD FOR LONG-TERM TREATMENT OF ROSACEA
    8.
    发明申请
    METHOD FOR LONG-TERM TREATMENT OF ROSACEA 审中-公开

    公开(公告)号：US20200261400A1

    公开(公告)日：2020-08-20

    申请号：US16794887

    申请日：2020-02-19

    Applicant: Sol-Gel Technologies Ltd.

    Inventor： Ofer TOLEDANO ,  Ofra LEVY-HACHAM ,  Ori NOV ,  Vered RAM

    IPC: A61K31/327 ,  A61P17/10 ,  A61K9/107

    Abstract: A regimen for the long-term therapeutic treatment of rosacea. The regimen includes topically applying to the skin of a subject in need of said treatment a pharmaceutical composition. The pharmaceutical composition includes about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient. The benzoyl peroxide is the only active ingredient in said pharmaceutical composition, and the pharmaceutical composition is applied once daily for a period of up to about 40 weeks to about 52 weeks, to achieve, in a group of such subjects, a success rate of about 75% to about 85%.

    METHOD FOR TREATMENT OF ROSACEA IN PATIENTS AGED 65 YEARS AND OLDER
    9.
    发明申请
    METHOD FOR TREATMENT OF ROSACEA IN PATIENTS AGED 65 YEARS AND OLDER 审中-公开

    公开(公告)号：US20200261399A1

    公开(公告)日：2020-08-20

    申请号：US16794839

    申请日：2020-02-19

    Applicant: Sol-Gel Technologies Ltd.

    Inventor： Ofer TOLEDANO ,  Ofra LEVY-HACHAM ,  Ori NOV ,  Vered RAM

    IPC: A61K31/327 ,  A61K9/06 ,  A61K9/107 ,  A61P17/10

    Abstract: A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.

    METHOD FOR PROVIDING EARLY ONSET OF ACTION IN THE TREATMENT OF ROSACEA
    10.
    发明申请
    METHOD FOR PROVIDING EARLY ONSET OF ACTION IN THE TREATMENT OF ROSACEA 审中-公开

    公开(公告)号：US20200261397A1

    公开(公告)日：2020-08-20

    申请号：US16794734

    申请日：2020-02-19

    Applicant: Sol-Gel Technologies Ltd.

    Inventor： Ofer TOLEDANO ,  Ofra LEVY-HACHAM ,  Ori NOV ,  Vered RAM

    IPC: A61K31/327 ,  A61P17/00 ,  A61K9/50

    Abstract: A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment. The pharmaceutical composition includes about 1% to about 10% benzoyl peroxide as the only active ingredient, and a pharmaceutically acceptable carrier or excipient. The pharmaceutical composition is applied once daily for a period of at least about 2, 4, 8 or 12 weeks. Based on early onset of action, a primary measure of success is at least about 9%, primary measure of success being defined as a 2-grade improvement in IGA of clear or almost clear; and a secondary measure of success is at least about 40%, secondary measure of success being defined as mean inflammatory lesion count percent reduction from baseline, after at least about 2 weeks of treatment.

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