公开(公告)号：US20230121990A1

公开(公告)日：2023-04-20

申请号：US17905736

申请日：2021-03-06

申请人： Solugen, Inc.

发明人： Toni M. Lee ,  Shuai Qian ,  Brian F. Fisher ,  Sarah Downing ,  Gaurab Chakrabarti ,  Sean Hunt

IPC分类号： C12P17/06 ,  C12P17/04 ,  C12N9/04 ,  C12N9/08 ,  C12N9/02

摘要： A chemoenzymatic process for the preparation of an oxidized glucose product comprising contacting D-glucose with an enzyme selected from the group consisting essentially of galactose oxidase (GAO), glucose oxidase (GOX), polysaccharide monooxygenase, catalase, animal peroxidase, periplasmic aldehyde oxidase (Pao), unspecific peroxygenase (UPO), lactoperoxidase (LPO), myeloperoxidase (MPO), eosinophil peroxidase (EPO), thyroid peroxidase (TPO), ovoperoxidase, salivary peroxidase, vanadium haloperoxidase, non-mammalian vertebrate peroxidase (POX), peroxidasin (Pxd), bacterial peroxicin (Pxc), invertebrate peroxinectin (Pxt), short peroxidockerin (PxDo), alpha-dioxygenase (aDox), dual oxidase (DuOx), prostaglandin H synthase (PGHS), cyclooxygenase (CyOx), linoleate diol synthase (LDS), variants thereof, and combinations thereof under conditions suitable for the formation of an oxidized intermediate; and contacting the oxidized intermediate with a metal catalyst to form an oxidized glucose product.

公开(公告)号：US20230096662A1

公开(公告)日：2023-03-30

申请号：US17910849

申请日：2021-02-25

申请人： Solugen, Inc.

发明人： Toni M. Lee ,  Shuai Qian ,  Brian F. Fisher ,  Phillip Wiemann ,  Hans-Joerg Woelk ,  Gaurab Chakrabarti ,  Sean Hunt ,  Konrad V. Miller

IPC分类号： C12P17/04 ,  C12N9/08 ,  C12N9/04

摘要： A chemoenzymatic process for the preparation of 2,5-furan dicarboxylic acid includes contacting D-glucose with (i) at least two enzymes selected from the group consisting essentially of galactose oxidase, pyranose 2-oxidase, glucarate dehydratase, catalase and a combination thereof to produce an intermediate; and (ii) a heterogeneous metal catalyst to form 2,5-furan dicarboxylic acid.