公开(公告)号：US12295369B2

公开(公告)日：2025-05-13

申请号：US17597488

申请日：2020-07-23

Applicant: Solventum Intellectual Properties Company

Inventor： Andrew W. Vail ,  Jerald K. Rasmussen ,  Robert A. Schmitz

IPC: A01N47/44 ,  A01N25/10 ,  A01N25/34

Abstract: An article, and method of use, wherein the article includes: a substrate; a cationic coating bound to the substrate, wherein the cationic coating includes a guanidinyl-containing polymer that is crosslinked on the substrate; wherein the guanidinyl-containing polymer is of the following Formula (I), wherein: R3 is a H, C1-C12(hetero)alkyl, C5-C12(hetero)aryl, or Polymer; each R4 is independently H, C1-C12(hetero)alkyl, or C5-C12(hetero)aryl; each R5 is H, C1-C12(hetero)alkyl, C5-C12(hetero)aryl, or N(R4)2; Polymer is a residue of an aminopolymer chain; m is 1 or 2; and x is an integer of at least 1; and wherein the guanidinyl-containing polymer is crosslinked with an amine-reactive polyepoxy compound having pendant —OH groups.

公开(公告)号：US20240409905A1

公开(公告)日：2024-12-12

申请号：US18689462

申请日：2022-08-04

Applicant: Solventum Intellectual Properties Company

Inventor： Kenneth C. Koehler ,  Alexei M. Voloshin ,  Ki-Joo Sung ,  Narendranath Bhokisham ,  Andrew W. Vail ,  Kristopher E. Richardson ,  Rebecca A. Hochstein

IPC: C12N7/00

Abstract: A method. The method includes providing a filter medium comprising a functionalized nonwoven; passing a first fluid containing cells through the filter medium, wherein at least some of the cells are captured by the functionalized nonwoven; passing a second fluid, and optionally a third and/or fourth fluid through the filter medium, wherein the second and/or third and/or fourth fluid disrupts at least one of the captured cells; and recovering an intracellular biological product in the first and/or second and/or third and/or fourth fluid.