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1.发明授权公开(公告)号：US08338616B2
公开(公告)日：2012-12-25
申请号：US13120009
申请日：2009-09-15
申请人： Song Li , Wu Zhong , Lili Wang , Zhibing Zheng , Hao Cui , Junhai Xiao , Gang Cheng , Yunde Xie , Bing Zhang
发明人： Song Li , Wu Zhong , Lili Wang , Zhibing Zheng , Hao Cui , Junhai Xiao , Gang Cheng , Yunde Xie , Bing Zhang
IPC分类号： A61K31/426 , C07D277/30
CPC分类号： C07D277/22 , A61K8/49 , A61K31/426 , A61Q11/00 , A61Q19/08
摘要： The present invention relates to a composition of a thiazolium compound of formula I or a solvate thereof, wherein the definitions of groups in the formula I are as those given in the claims:
摘要翻译： 本发明涉及式I的噻唑鎓化合物或其溶剂化物的组合物，其中式I中基团的定义如权利要求中给出的那些：
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2.发明申请公开(公告)号：US20110178141A1
公开(公告)日：2011-07-21
申请号：US13120009
申请日：2009-10-15
申请人： Song Li , Wu Zhong , Lili Wang , Zhibing Zheng , Hao Cui , Junhai Xiao , Gang Cheng , Yunde Xie , Bing Zhang
发明人： Song Li , Wu Zhong , Lili Wang , Zhibing Zheng , Hao Cui , Junhai Xiao , Gang Cheng , Yunde Xie , Bing Zhang
IPC分类号： A61K31/426 , C07D277/30 , A61P17/00 , A61P3/10 , A61P13/12 , A61P27/02 , A61P27/12 , A61P25/00 , A61P19/02
CPC分类号： C07D277/22 , A61K8/49 , A61K31/426 , A61Q11/00 , A61Q19/08
摘要： The present invention relates to a composition of a thiazolium compound of formula I or a solvate thereof, wherein the definitions of groups in the formula I are as those given in the claims:
摘要翻译： 本发明涉及式I的噻唑鎓化合物或其溶剂化物的组合物，其中式I中基团的定义如权利要求中给出的那些：
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3.发明申请Optically Pure Dihydropyrimidine Compounds and Their Uses for the Preparation of a Medicament for Treatment and Prevention of Viral Diseases 有权光学纯二氢嘧啶化合物及其用于制备治疗和预防病毒性疾病药物的用途公开(公告)号：US20100004268A1
公开(公告)日：2010-01-07
申请号：US12373101
申请日：2007-07-09
申请人： Song Li , Guangqiang Xia , Guoming Zhao , Lili Wang , Zhibing Zheng , Yunde Xie , Wu Zhong , Junhai Xiao , Xingzhou Li , Hao Cui
发明人： Song Li , Guangqiang Xia , Guoming Zhao , Lili Wang , Zhibing Zheng , Yunde Xie , Wu Zhong , Junhai Xiao , Xingzhou Li , Hao Cui
IPC分类号： A61K31/505 , C07D417/04 , C07D239/20 , A61K31/506
CPC分类号： C07D417/04 , C07D239/20 , C07D239/28
摘要： The present invention relates to an optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing the optically pure compound of formula (I), and use of the optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
摘要翻译： 本发明涉及光学纯的式（I）化合物或其药学上可接受的盐或水合物，制备光学纯的式（I）化合物的方法，以及使用光学纯的式（I）化合物或 其药学上可接受的盐或水合物作为药物，特别是作为治疗和预防B型肝炎的药物。
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4.发明申请Substitued A-Piperazingly Phenylpropionic Acid Derivatives As Hppar Alpha And/Or Hppar Gamma Agonists 有权取代的A-Piperazingly苯丙酸衍生物作为Hppar Alpha和/或Hppar伽玛激动剂公开(公告)号：US20070259883A1
公开(公告)日：2007-11-08
申请号：US11569575
申请日：2005-02-02
申请人： Song Li , Xinbo Zhou , Lili Wang , Cheng Xu , Chengmai Ruan , Cuifang Lin , Junhai Xiao , Zhibing Zheng , Hongying Liu , Yunde Xie , Wu Zhong , Hao Cui
发明人： Song Li , Xinbo Zhou , Lili Wang , Cheng Xu , Chengmai Ruan , Cuifang Lin , Junhai Xiao , Zhibing Zheng , Hongying Liu , Yunde Xie , Wu Zhong , Hao Cui
IPC分类号： A61K31/497 , C07D263/30 , C07D413/02
CPC分类号： C07D263/32
摘要： The present invention relates to a compound of formula I, racemates, optically active isomers, or pharmaceutically acceptable salts or solvates thereof, and a pharmaceutical composition comprising the compound, the various radicals in the formula I are the same as defined in the claims. The present invention also relates to a process for preparing the compound of formula I and use of said compound in the preparation of a medicament for the treatment of hyperglycemia, dyslipidemia, type II diabetes mellitus including associated diabetic dyslipidemia
摘要翻译： 本发明涉及式I化合物，外消旋体，旋光异构体或其药学上可接受的盐或溶剂合物，以及包含该化合物的药物组合物，式I中的各种基团与权利要求中所定义相同。 本发明还涉及制备式I化合物的方法，以及所述化合物在制备用于治疗高血糖，血脂异常，II型糖尿病的药物中的用途，所述II型糖尿病包括相关的糖尿病性血脂异常
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5.发明授权Optically pure dihydropyrimidine compounds and their uses for the preparation of a medicament for treatment and prevention of viral diseases 有权光学纯二氢嘧啶化合物及其用于制备用于治疗和预防病毒性疾病的药物的用途公开(公告)号：US08329902B2
公开(公告)日：2012-12-11
申请号：US12373101
申请日：2007-07-09
申请人： Song Li , Guangqiang Xia , Guoming Zhao , Lili Wang , Zhibing Zheng , Yunde Xie , Wu Zhong , Junhai Xiao , Xingzhou Li , Hao Cui
发明人： Song Li , Guangqiang Xia , Guoming Zhao , Lili Wang , Zhibing Zheng , Yunde Xie , Wu Zhong , Junhai Xiao , Xingzhou Li , Hao Cui
IPC分类号： C07D239/02 , C07D239/00 , C07D401/00
CPC分类号： C07D417/04 , C07D239/20 , C07D239/28
摘要： The present invention relates to an optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing the optically pure compound of formula (I), and use of the optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
摘要翻译： 本发明涉及光学纯的式（I）化合物或其药学上可接受的盐或水合物，制备光学纯的式（I）化合物的方法，以及使用光学纯的式（I）化合物或 其药学上可接受的盐或水合物作为药物，特别是作为治疗和预防B型肝炎的药物。
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6.发明授权Dihydropyrimidine compounds and their uses in preparation of medicaments for treating and preventing antiviral diseases 有权二氢嘧啶化合物及其在制备用于治疗和预防抗病毒疾病的药物中的用途公开(公告)号：US08168642B2
公开(公告)日：2012-05-01
申请号：US12373183
申请日：2007-07-09
申请人： Song Li , Guoming Zhao , Guangqiang Xia , Lili Wang , Zhibing Zheng , Yunde Xie , Wu Zhong , Junhai Xiao , Xingzhou Li , Hao Cui
发明人： Song Li , Guoming Zhao , Guangqiang Xia , Lili Wang , Zhibing Zheng , Yunde Xie , Wu Zhong , Junhai Xiao , Xingzhou Li , Hao Cui
IPC分类号： C07D239/20 , C07D403/04 , A61K31/506
CPC分类号： C07D239/20 , C07D403/04 , C07D417/04
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐或水合物，涉及制备式（I）化合物的方法，以及使用式（I）化合物或其药学上可接受的盐 或其水合物作为药物，特别是作为治疗和预防B型肝炎的药物。
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7.发明申请Dihydropyrimidine Compounds and Their Uses in Preparation of Medicaments for Treating and Preventing Antiviral Diseases 有权二氢嘧啶化合物及其用于制备治疗和预防抗病毒疾病药物的用途公开(公告)号：US20100087448A1
公开(公告)日：2010-04-08
申请号：US12373183
申请日：2007-07-09
申请人： Song Li , Guoming Zhao , Guangqiang Xia , Lili Wang , Zhibing Zheng , Yunde Xie , Wu Zhong , Junhai Xiao , Xingzhou Li , Hao Cui
发明人： Song Li , Guoming Zhao , Guangqiang Xia , Lili Wang , Zhibing Zheng , Yunde Xie , Wu Zhong , Junhai Xiao , Xingzhou Li , Hao Cui
IPC分类号： A61K31/505 , C07D239/02 , A61K31/506 , C07D403/04 , C07D417/04
CPC分类号： C07D239/20 , C07D403/04 , C07D417/04
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐或水合物，涉及制备式（I）化合物的方法，以及使用式（I）化合物或其药学上可接受的盐 或其水合物作为药物，特别是作为治疗和预防B型肝炎的药物。
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8.发明授权Substituted α-piperazinyl phenylpropionic acid derivatives as hPPAR α and/or hPPAR γ agonists 有权取代的α-哌嗪基苯丙酸衍生物作为hPPARα和/或hPPARγ激动剂公开(公告)号：US07544687B2
公开(公告)日：2009-06-09
申请号：US11569575
申请日：2005-02-02
申请人： Song Li , Xinbo Zhou , Lili Wang , Cheng Xu , Chengmai Ruan , Cuifang Lin , Junhai Xiao , Zhibing Zheng , Hongying Liu , Yunde Xie , Wu Zhong , Hao Cui
发明人： Song Li , Xinbo Zhou , Lili Wang , Cheng Xu , Chengmai Ruan , Cuifang Lin , Junhai Xiao , Zhibing Zheng , Hongying Liu , Yunde Xie , Wu Zhong , Hao Cui
IPC分类号： A61K31/496 , C07D263/32
CPC分类号： C07D263/32
摘要： The present invention relates to a compound of formula I, racemates, optically active isomers, or pharmaceutically acceptable salts or solvates thereof, and a pharmaceutical composition comprising the compound, the various radicals in the formula I are the same as defined in the claims. The present invention also relates to a process for preparing the compound of formula I and use of said compound in the preparation of a medicament for the treatment of hyperglycemia, dyslipidemia, type II diabetes mellitus including associated diabetic dyslipidemia.
摘要翻译： 本发明涉及式I化合物，外消旋体，旋光异构体或其药学上可接受的盐或溶剂合物，以及包含该化合物的药物组合物，式I中的各种基团与权利要求中所定义相同。 本发明还涉及制备式I化合物的方法和所述化合物在制备用于治疗高血糖，血脂异常，II型糖尿病，包括相关糖尿病性血脂异常的药物中的应用。
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公开(公告)号：US09034382B2
公开(公告)日：2015-05-19
申请号：US12225935
申请日：2006-08-11
申请人： Song Li , Wu Zhong , Junhai Xiao , Yunde Xie , Xingzhou Li , Hao Cui , Zhibing Zheng
发明人： Song Li , Wu Zhong , Junhai Xiao , Yunde Xie , Xingzhou Li , Hao Cui , Zhibing Zheng
IPC分类号： A61K9/14 , A61K31/215 , A61K9/16 , A61K9/00
CPC分类号： A61K31/215 , A61K9/0056 , A61K9/0095 , A61K9/141 , A61K9/1623 , A61K9/1635 , A61K9/1652
摘要： The present invention relates to an oseltamivir phosphate granule and preparation method thereof. The said granule comprises 1.97-19.8 wt. % oseltamivir phosphate, 75.0-97.5 wt. % diluent, 0.1-5.0 wt. % binder, optionally 1.0-5.0 wt. % edible flavoring essence, sweetener and/or edible pigment. It is prepared by using 30-55 v/v % aqueous ethanol solution as moistening agent. The granules prepared by the formulation and method according to the present invention have good uniformity and stability and are water-soluble. The administration dosage of the granules can be conveniently selected based on the age and body weight of patients. The oseltamivir phosphate granule is suitable for administering to old people, children and flu gravis patients and those patients that swallow inconveniently or difficulty. The preparation of the granule is simple and low in production cost.
摘要翻译： 本发明涉及磷酸奥司他韦颗粒及其制备方法。 所述颗粒包含1.97-19.8wt。 磷酸奥司他韦，75.0-97.5wt。 ％稀释剂，0.1-5.0wt。 ％粘合剂，任选地1.0-5.0wt。 ％可食用香精，甜味剂和/或食用色素。 通过使用30-55v / v％乙醇水溶液作为润湿剂制备。 通过本发明的制剂和方法制备的颗粒具有良好的均匀性和稳定性，并且是水溶性的。 可以根据患者的年龄和体重方便地选择颗粒的给药剂量。 奥司他韦磷酸盐颗粒适用于老年人，儿童和流感重症患者以及吞咽困难或困难的患者。 颗粒的制备简单，生产成本低。
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10.发明申请公开(公告)号：US20090176877A1
公开(公告)日：2009-07-09
申请号：US12225935
申请日：2006-08-11
申请人： Song Li , Wu Zhong , Junhai Xiao , Yunde Xie , Xingzhou Li , Hao Cui , Zhibing Zheng
发明人： Song Li , Wu Zhong , Junhai Xiao , Yunde Xie , Xingzhou Li , Hao Cui , Zhibing Zheng
IPC分类号： A61K31/215
CPC分类号： A61K31/215 , A61K9/0056 , A61K9/0095 , A61K9/141 , A61K9/1623 , A61K9/1635 , A61K9/1652
摘要： The present invention relates to an oseltamivir phosphate granule and preparation method thereof. The said granule comprises 1.97-19.8 wt. % oseltamivir phosphate, 75.0-97.5 wt. % diluent, 0.1-5.0 wt. % binder, optionally 1.0-5.0 wt. % edible flavouring essence, sweetener and/or edible pigment. It is prepared by using 30-55 v/v % aqueous ethanol solution as moistening agent. The granules prepared by the formulation and method according to the present invention have good uniformity and stability and are water-soluble. The administration dosage of the granules can be conveniently selected based on the age and body weight of patients. The oseltamivir phosphate granule is suitable for administering to old people, children and flu gravis patients and those patients that swallow inconveniently or difficulty. The preparation of the granule is simple and low in production cost.
摘要翻译： 本发明涉及磷酸奥司他韦颗粒及其制备方法。 所述颗粒包含1.97-19.8wt。 磷酸奥司他韦，75.0-97.5wt。 ％稀释剂，0.1-5.0wt。 ％粘合剂，任选地1.0-5.0wt。 ％可食用香精，甜味剂和/或食用色素。 通过使用30-55v / v％乙醇水溶液作为润湿剂制备。 通过本发明的制剂和方法制备的颗粒具有良好的均匀性和稳定性，并且是水溶性的。 可以根据患者的年龄和体重方便地选择颗粒的给药剂量。 奥司他韦磷酸盐颗粒适用于老年人，儿童和流感重症患者以及吞咽困难或困难的患者。 颗粒的制备简单，生产成本低。
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