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公开(公告)号：US11231436B2
公开(公告)日：2022-01-25
申请号：US16608187
申请日：2018-02-16
发明人： Isamu Nakao , Noriyuki Kishii , Tetsuro Kuwayama , Kensei Jo
摘要： The flow rate of light scattering fluid is measured more easily and at a higher speed.
A flow rate measuring method according to the present disclosure includes: generating two or more speckle images by continually imaging light scattering fluid to be measured, while defining time shorter than spatial correlation disappearance time corresponding to time in which spatial correlation between speckle patterns generated by the light scattering fluid disappears as exposure time, at a time interval shorter than the spatial correlation disappearance time; and calculating direction and speed of flow of the light scattering fluid from time variation of the speckle patterns between the two or more speckle images, in which the speckle images are imaged by using an imaging device mounted with an area sensor and a pixel group of a part of the area sensor or by using an imaging device mounted with a line sensor.-
公开(公告)号：US20190045112A1
公开(公告)日：2019-02-07
申请号：US16076447
申请日：2016-12-09
申请人： Sony Corporation
发明人： Hiroshi Ichiki , Isamu Nakao , Tetsuro Kuwayama , Noriyuki Kishii , Yusaku Nakashima , Takeshi Matsui
摘要： The imaging apparatus includes a coherent light source that irradiates an imaging object with coherent light, an incoherent light source that irradiates the imaging object with incoherent light, a speckle imaging unit that captures a speckle image obtained from scattered light of the imaging object irradiated with the coherent light, a non-speckle imaging unit that captures a non-speckle image obtained from reflected light of the imaging object irradiated with the incoherent light, and a focus detection unit that detects a focus of the speckle imaging unit on the basis of a focal position of the non-speckle imaging unit.
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公开(公告)号：US20190293554A1
公开(公告)日：2019-09-26
申请号：US16086135
申请日：2017-01-20
申请人： Sony Corporation
发明人： Isamu Nakao , Takuya Kishimoto , Noriyuki Kishii
IPC分类号： G01N21/47
摘要： A fluid located at a certain depth in an imaging object can be imaged with high sensitivity and accuracy. As a result, an imaging technique by which information regarding the fluid can be accurately obtained is provided. An imaging apparatus includes: a light irradiation unit that irradiates a plurality of positions of an imaging object with coherent light as spots; a light detection unit that detects light, the light being emitted from the light irradiation unit and propagated in the imaging object; and an imaging unit that captures a speckle image obtained from scattered light of the imaging object, the scattered light being detected by the light detection unit.
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公开(公告)号：US20150276608A1
公开(公告)日：2015-10-01
申请号：US14665465
申请日：2015-03-23
申请人： Sony Corporation
IPC分类号： G01N21/65 , G01N33/574
CPC分类号： G01N21/65 , G01N33/5011 , G01N33/54373 , G01N33/57492 , G01N33/57496
摘要： According to an embodiment of the present disclosure, there is provided a biomolecule detection apparatus including a light emission unit, a measuring unit and an analysis unit. The light emission unit is configured to emit excitation light to living cells, the living cells having been in contact with an antitumor drug in advance. The measuring unit is configured to measure a Raman spectrum of the living cells. The analysis unit is configured to analyze whether or not the antitumor drug and a target biomolecule are bound with each other on the surface or inside of the living cells, based on the Raman spectrum.
摘要翻译： 根据本公开的实施方案，提供了包括发光单元，测量单元和分析单元的生物分子检测装置。 发光单元被配置为向活细胞发射激发光，活细胞预先与抗肿瘤药物接触。 测量单元被配置为测量活细胞的拉曼光谱。 分析单元被配置为基于拉曼光谱来分析抗肿瘤药物和靶生物分子是否在活细胞的表面或内部彼此结合。
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公开(公告)号：US10681259B2
公开(公告)日：2020-06-09
申请号：US16076447
申请日：2016-12-09
申请人： Sony Corporation
发明人： Hiroshi Ichiki , Isamu Nakao , Tetsuro Kuwayama , Noriyuki Kishii , Yusaku Nakashima , Takeshi Matsui
IPC分类号： H04N5/232 , A61B5/026 , G02B27/48 , H04N5/235 , G02B7/32 , A61B5/00 , H04N5/217 , A61B1/04 , G02B7/28 , H04N9/04 , G02B7/09 , G02B27/00 , H04N5/225 , G02B23/24 , A61B90/00
摘要： Provided is an imaging technique capable of detecting a focus even in an imaging apparatus of a speckle image.The imaging apparatus includes a coherent light source that irradiates an imaging object with coherent light, an incoherent light source that irradiates the imaging object with incoherent light, a speckle imaging unit that captures a speckle image obtained from scattered light of the imaging object irradiated with the coherent light, a non-speckle imaging unit that captures a non-speckle image obtained from reflected light of the imaging object irradiated with the incoherent light, and a focus detection unit that detects a focus of the speckle imaging unit on the basis of a focal position of the non-speckle imaging unit.
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公开(公告)号：US10031023B2
公开(公告)日：2018-07-24
申请号：US15547303
申请日：2016-01-14
申请人： SONY CORPORATION
摘要： Provided is a highly accurate imaging technology that utilizes the speckle interference. The present technology provides a speckle imaging device including: an irradiation condition setting unit that sets an irradiation condition for coherent light with which an imaging object is irradiated; an imaging unit that captures scattered light obtained from the imaging object irradiated with the coherent light; an image generation unit that generates a speckle-enhanced image from a captured image captured by the imaging unit; and a leveling processing unit that generates a leveled speckle image from speckle-enhanced images corresponding to two or more different irradiation conditions.
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公开(公告)号：US11025812B2
公开(公告)日：2021-06-01
申请号：US16067662
申请日：2016-11-16
申请人： SONY CORPORATION
发明人： Hiroshi Ichiki , Isamu Nakao , Tetsuro Kuwayama , Noriyuki Kishii , Yusaku Nakashima , Takeshi Matsui
摘要： To provide an image analyzing technology capable of obtaining an image with less shading and with enough speckle contrast. An imaging apparatus includes: a light source that irradiates an imaging object with coherent light with a first irradiation condition and a second irradiation condition; a speckle imaging unit that captures a first speckle image obtained from scattered light of the imaging object irradiate at the first irradiation condition, and a second speckle image obtained from scattered light of the imaging object irradiate at the second irradiation condition; and an information processing unit that separates speckle images at boundaries of average luminance difference formed in the first speckle image and the second speckle image, connecting the separaged speckle images at the boundaries, and analyzes the combined speckle combined image.
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公开(公告)号：US20140334981A1
公开(公告)日：2014-11-13
申请号：US14286300
申请日：2014-05-23
申请人： Sony Corporation
发明人： Kenzo Machida , Noriyuki Kishii , Mari Ichimura , Kazumine Ito , Takuya Kishimoto , Naohisa Sakamoto
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N21/6452
摘要： Provided is a microbead analysis method for a microbead. The microbead is formed in a columnar shape having a top surface and a bottom surface facing each other, as placed almost in parallel, and a side surface extending therefrom, and carries an identification pattern formed on at least one of the top surface and the bottom surface and a substance immobilized on a surface thereof having affinity to an analyte substance. The method includes detecting fluorescence emitted from the microbead surface due to interaction of the analyte substance with the substance having affinity to the analyte substance from a region including a region of the top surface and the bottom surface where there is no identification pattern formed and the side surface.
摘要翻译： 微珠的微珠分析方法。 微珠形成为具有彼此面对的顶表面和底表面的几乎平行的柱状和从其延伸的侧表面，并且携带形成在顶表面和底部中的至少一个上的识别图案 表面和固定在其对分析物质具有亲和性的表面上的物质。 该方法包括检测由于分析物质与对分析物质具有亲和性的物质的相互作用而从微珠表面发射的荧光，该区域包括不形成识别图案的顶表面和底表面的区域，侧面 表面。
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