公开(公告)号：US20190041379A1

公开(公告)日：2019-02-07

申请号：US16074587

申请日：2016-11-14

Applicant: Sony Corporation

Inventor： Kenzo Machida ,  Shinji Omori ,  Yoshihito Hayashi ,  Marcaurele Brun

IPC: G01N33/49 ,  G01N27/12 ,  G01N33/86

Abstract: To provide a technique which is useful in verification of measurement accuracy before measurement in the measurement of electric characteristics of a blood sample.There is provided a sample for measurement of electric characteristics at least including a liquid containing a blood coagulation factor, and micro particles. The density of each of the micro particles is different from the density of the liquid containing the blood coagulation factor. In addition, there is provided an electric characteristic measuring apparatus and an electric characteristic measuring method as well each using the sample for measurement of electric characteristics.

公开(公告)号：US20140322761A1

公开(公告)日：2014-10-30

申请号：US14190865

申请日：2014-02-26

Applicant: Sony Corporation

Inventor： Tomohiko Nakamura ,  Kenzo Machida

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q2523/301 ,  C12Q2527/125 ,  C12Q2527/137 ,  C12Q2565/625

Abstract: Provided is a method of preparing a sample for nucleic acid amplification reaction, including: a procedure of dissolving a solid phase reagent at least containing DNA polymerase, cyclodextrin, and a binder, in a liquid containing a nucleic acid.

Abstract translation: 本发明提供了制备用于核酸扩增反应的样品的方法，包括：将含有至少含有DNA聚合酶，环糊精和粘合剂的固相试剂溶解在含有核酸的液体中的方法。

公开(公告)号：US11982667B2

公开(公告)日：2024-05-14

申请号：US17286074

申请日：2019-08-27

Applicant: SONY CORPORATION

Inventor： Aya Fuchigami ,  Seungmin Lee ,  Yoshihito Hayashi ,  Kenzo Machida

IPC: G01N33/49 ,  G01N27/22 ,  G01N33/50

CPC classification number: G01N33/4905 ,  G01N27/221 ,  G01N33/5044

Abstract: Provided is a platelet aggregation capacity analyzer including a blood coagulation system-analyzing unit that analyzes a platelet aggregation capacity based on measurement data during a coagulation process of a platelet-containing sample, and an output control unit that controls an output of results analyzed by the blood coagulation system-analyzing unit, in which the blood coagulation system-analyzing unit analyzes the platelet aggregation capacity of the platelet-containing sample based on the barb of measurement data during the coagulation process with a platelet aggregation inhibitor added to the platelet-containing sample and measurement data during the coagulation process without a platelet agonist or the platelet aggregation inhibitor added to the platelet-containing sample.

公开(公告)号：US10578604B2

公开(公告)日：2020-03-03

申请号：US15509091

申请日：2015-08-10

Applicant: SONY CORPORATION

Inventor： Kenzo Machida ,  Marcaurele Brun ,  Yoshihito Hayashi

IPC: G01N33/49 ,  G01N27/02

Abstract: To an electrical characteristic measuring device that further improves the accuracy of measurement of an electrical characteristic of a blood sample. Provided is an electrical characteristic measuring device including: a measuring unit configured to measure an electrical characteristic of a blood sample; and an alert generation unit configured to issue an alert signal when an erythrocyte sedimentation rate in the blood sample exceeds a prescribed standard during measurement of the blood sample.

公开(公告)号：US11802825B2

公开(公告)日：2023-10-31

申请号：US16337598

申请日：2017-07-21

Applicant: Sony Corporation

Inventor： Aya Murata ,  Yoshihito Hayashi ,  Kenzo Machida ,  Seungmin Lee

IPC: G01N11/00 ,  G01N19/00 ,  G01N27/22 ,  G01N33/49 ,  G01N33/86

CPC classification number: G01N11/00 ,  G01N19/00 ,  G01N27/22 ,  G01N33/49 ,  G01N33/86 ,  G01N2011/0066

Abstract: A measurement method of simply and quickly measuring platelet aggregation, is provided.
The measurement method is a platelet aggregation analysis method, including:



a step of adding a platelet-inducing substance and a calcium salt to a platelet-containing specimen;
a step of stirring the platelet-containing specimen; and a step of acquiring measurement data of an electrical characteristic and/or viscoelasticity of the platelet-containing specimen.

公开(公告)号：US10816493B2

公开(公告)日：2020-10-27

申请号：US15560039

申请日：2016-02-29

Applicant: SONY CORPORATION

Inventor： Seungmin Lee ,  Kenzo Machida ,  Kaori Kawaguchi ,  Marcaurele Brun

IPC: G01N27/02 ,  G01N33/49 ,  G01N33/86 ,  G01N33/80

Abstract: Provided is a technique that allows high-accuracy electrical measurement without the influence of blood sedimentation in a case where various measurements or evaluations are performed using blood samples containing a blood cell component and a plasma component. Provided is an electrical measurement method for electrically measuring a blood sample including at least a blood cell component and a plasma component, the electrical measurement method including the step of adding a blood sedimentation inhibitor to the blood sample. Also provided is a blood sedimentation inhibitor for use in electrical measurement of a blood sample including at least a blood cell component and a plasma component, the blood sedimentation inhibitor including a non-cationic water-soluble compound and being capable of increasing specific gravity and/or viscosity of the plasma component.

公开(公告)号：US10234469B2

公开(公告)日：2019-03-19

申请号：US15302914

申请日：2015-04-09

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49

Abstract: A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.

公开(公告)号：US20170023597A1

公开(公告)日：2017-01-26

申请号：US15302562

申请日：2015-02-19

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49 ,  G01N27/02

Abstract: To provide a technology that allows for simple and highly accurate evaluation of the condition of blood.Provided is a blood condition analysis device, for analyzing the condition of a blood sample having added thereto at least one kind of drug selected from the group consisting of anticoagulation treatment canceling agents, coagulation activators, anticoagulants, platelet activators, and antiplatelet agents, the device including a drug dosage control unit for controlling the dosage of the drug to be added to the blood sample on the basis of the hematocrit and/or hemoglobin content of the blood sample.

Abstract translation: 本发明提供一种血液分析装置，用于分析添加了选自抗凝治疗消除剂，凝血激活剂，抗凝剂，血小板活化剂和抗血小板剂中的至少一种药物的血液样品的状态，该装置 包括用于基于血液样品的血细胞比容和/或血红蛋白含量控制待添加到血液样品中的药物的剂量的药物剂量控制单元。

公开(公告)号：US20140334981A1

公开(公告)日：2014-11-13

申请号：US14286300

申请日：2014-05-23

Applicant: Sony Corporation

Inventor： Kenzo Machida ,  Noriyuki Kishii ,  Mari Ichimura ,  Kazumine Ito ,  Takuya Kishimoto ,  Naohisa Sakamoto

IPC: G01N33/543

CPC classification number: G01N33/54366 ,  G01N21/6452

Abstract: Provided is a microbead analysis method for a microbead. The microbead is formed in a columnar shape having a top surface and a bottom surface facing each other, as placed almost in parallel, and a side surface extending therefrom, and carries an identification pattern formed on at least one of the top surface and the bottom surface and a substance immobilized on a surface thereof having affinity to an analyte substance. The method includes detecting fluorescence emitted from the microbead surface due to interaction of the analyte substance with the substance having affinity to the analyte substance from a region including a region of the top surface and the bottom surface where there is no identification pattern formed and the side surface.

Abstract translation: 微珠的微珠分析方法。 微珠形成为具有彼此面对的顶表面和底表面的几乎平行的柱状和从其延伸的侧表面，并且携带形成在顶表面和底部中的至少一个上的识别图案 表面和固定在其对分析物质具有亲和性的表面上的物质。 该方法包括检测由于分析物质与对分析物质具有亲和性的物质的相互作用而从微珠表面发射的荧光，该区域包括不形成识别图案的顶表面和底表面的区域，侧面 表面。

公开(公告)号：US20210341498A1

公开(公告)日：2021-11-04

申请号：US17271540

申请日：2019-09-06

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Seunmin Lee ,  Aya Fuchigami ,  Kenzo Machida

IPC: G01N33/86 ,  G01N27/02

Abstract: There is provided a blood-clotting-system analysis apparatus, including: a pair of electrodes; an application unit configured to apply alternating voltage to the pair of electrodes at predetermined time intervals; a measurement unit configured to measure a complex dielectric constant of a blood sample placed between the pair of electrodes; and an analysis unit configured to analyze, by using at least two or more types of blood clotting-related assays, activity of a clotting factor and activity of a clotting inhibition factor on a basis of a complex dielectric constant of a particular frequency in a predetermined time period measured at the time intervals after an anticoagulant effect acting on the blood sample is resolved.