公开(公告)号：US20090325953A1

公开(公告)日：2009-12-31

申请号：US12481614

申请日：2009-06-10

申请人： Soumya P. Sahoo ,  Meng-Hsin Chen ,  Kevin D. Dykstra ,  Hiroo Koyama ,  Peter T. Meinke ,  Stephen J. O'Keefe ,  Ginger Xu-qiang Yang

发明人： Soumya P. Sahoo ,  Meng-Hsin Chen ,  Kevin D. Dykstra ,  Hiroo Koyama ,  Peter T. Meinke ,  Stephen J. O'Keefe ,  Ginger Xu-qiang Yang

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61K31/519 ,  A61K31/5025 ,  A61K31/5377 ,  A61P11/06 ,  A61P19/00

CPC分类号： C07D519/00

摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗哮喘，COPD，ARDS，类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和 其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。

公开(公告)号：US08017605B2

公开(公告)日：2011-09-13

申请号：US12481614

申请日：2009-06-10

申请人： Soumya P. Sahoo ,  Meng-Hsin Chen ,  Kevin D. Dykstra ,  Hiroo Koyama ,  Peter T. Meinke ,  Stephen J. O'Keefe ,  Ginger Xu-qiang Yang

发明人： Soumya P. Sahoo ,  Meng-Hsin Chen ,  Kevin D. Dykstra ,  Hiroo Koyama ,  Peter T. Meinke ,  Stephen J. O'Keefe ,  Ginger Xu-qiang Yang

IPC分类号： A61K31/437 ,  A61K31/519 ,  A61K31/5025 ,  A61K31/5377 ,  C07D471/04 ,  A61P11/06 ,  A61P19/00

CPC分类号： C07D519/00

摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗哮喘，COPD，ARDS，类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和 其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。

公开(公告)号：US4815728A

公开(公告)日：1989-03-28

申请号：US127264

申请日：1987-12-01

申请人： Stephen J. O'Keefe

发明人： Stephen J. O'Keefe

IPC分类号： A63G27/00 ,  A63G27/02 ,  A63G1/00

CPC分类号： A63G27/00 ,  A63G27/02

摘要： A Ferris wheel amusement ride has a main wheel supported by a shaft secured on top of two towers. A plurality of subwheels is mounted on the periphery of the main wheel and a plurality of passenger cabs is pivotally mounted on and with their longitudinal axes along, the periphery of the subwheels. A hydraulic system is provided for independently driving the main wheel and the subwheels. The passenger cabs are manually rotated by the passengers about the longitudinal axes thereof.

摘要翻译： 摩天轮游乐设施有一个由两个塔顶部固定的轴支撑的主轮。 多个副轮安装在主轮的周边上，并且多个乘用驾驶室沿着副轮周边枢转地安装在其纵轴上。 提供用于独立地驱动主轮和副轮的液压系统。 乘客围绕其纵向轴线被乘客手动地旋转。