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公开(公告)号：US20090325953A1
公开(公告)日：2009-12-31
申请号：US12481614
申请日：2009-06-10
申请人： Soumya P. Sahoo , Meng-Hsin Chen , Kevin D. Dykstra , Hiroo Koyama , Peter T. Meinke , Stephen J. O'Keefe , Ginger Xu-qiang Yang
发明人： Soumya P. Sahoo , Meng-Hsin Chen , Kevin D. Dykstra , Hiroo Koyama , Peter T. Meinke , Stephen J. O'Keefe , Ginger Xu-qiang Yang
IPC分类号： A61K31/437 , C07D471/04 , A61K31/519 , A61K31/5025 , A61K31/5377 , A61P11/06 , A61P19/00
CPC分类号： C07D519/00
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗哮喘，COPD，ARDS，类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和 其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US08017605B2
公开(公告)日：2011-09-13
申请号：US12481614
申请日：2009-06-10
申请人： Soumya P. Sahoo , Meng-Hsin Chen , Kevin D. Dykstra , Hiroo Koyama , Peter T. Meinke , Stephen J. O'Keefe , Ginger Xu-qiang Yang
发明人： Soumya P. Sahoo , Meng-Hsin Chen , Kevin D. Dykstra , Hiroo Koyama , Peter T. Meinke , Stephen J. O'Keefe , Ginger Xu-qiang Yang
IPC分类号： A61K31/437 , A61K31/519 , A61K31/5025 , A61K31/5377 , C07D471/04 , A61P11/06 , A61P19/00
CPC分类号： C07D519/00
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗哮喘，COPD，ARDS，类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和 其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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![PYRROLO [2,3-C] PYRIDINE DERIVATIVES AS P38 KINEASE INHIBITING AGENTS](/abs-image/US/2011/05/05/US20110105430A1/abs.jpg.150x150.jpg)
3.发明申请PYRROLO [2,3-C] PYRIDINE DERIVATIVES AS P38 KINEASE INHIBITING AGENTS 审中-公开PYRROLO [2,3-C]吡啶衍生物作为P38激酶抑制剂公开(公告)号：US20110105430A1
公开(公告)日：2011-05-05
申请号：US12997524
申请日：2009-06-08
申请人： Soumya P. Sahoo , Meng-Hsin Chen , Kevin D. Dykstra , Hiroo Koyama , Peter T. Meinke , Stephen J. O'keefe , Ginger Xu-Qiang Yang
发明人： Soumya P. Sahoo , Meng-Hsin Chen , Kevin D. Dykstra , Hiroo Koyama , Peter T. Meinke , Stephen J. O'keefe , Ginger Xu-Qiang Yang
IPC分类号： A61K31/437 , C07D471/04 , A61K31/519 , A61K31/5025 , A61K31/5377 , C07F7/10 , A61K31/695 , A61P29/00 , A61P19/02 , A61P11/06 , A61P11/00
CPC分类号： C07D519/00
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (A) are inhibitors N of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：（A）是p38的抑制剂N，可用于治疗炎症，例如治疗哮喘，类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和 其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US08513289B2
公开(公告)日：2013-08-20
申请号：US13266043
申请日：2010-04-26
IPC分类号： A61K31/4245 , A61K31/433 , C07D285/08 , C07D207/333
CPC分类号： C07D417/12 , C07D417/14
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: Formula (I); are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：式（I）; 是p38的抑制剂，可用于治疗炎症，例如治疗哮喘，COPD，ARDS，类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US20120040999A1
公开(公告)日：2012-02-16
申请号：US13266043
申请日：2010-04-26
IPC分类号： A61K31/433 , C07D417/14 , A61K31/4439 , A61P19/10 , C07D487/04 , A61K31/519 , A61P29/00 , A61P11/00 , C07D417/12 , A61K31/497
CPC分类号： C07D417/12 , C07D417/14
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: Formula (I); are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：式（I）; 是p38的抑制剂，可用于治疗炎症，例如治疗哮喘，COPD，ARDS，类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US07879875B2
公开(公告)日：2011-02-01
申请号：US11990050
申请日：2006-08-08
申请人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor , Swaminathan R. Natarajan , Zhen Li , Soumya P. Sahoo
发明人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor , Swaminathan R. Natarajan , Zhen Li , Soumya P. Sahoo
IPC分类号： A61K31/4375 , C07D455/02
CPC分类号： C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症 ; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US20090131472A1
公开(公告)日：2009-05-21
申请号：US11990050
申请日：2006-08-08
申请人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor , Swaminathan R. Natarajan , Zhen Li , Soumya P. Sahoo
发明人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor , Swaminathan R. Natarajan , Zhen Li , Soumya P. Sahoo
IPC分类号： A61K31/4375 , C07D455/02 , A61P37/02
CPC分类号： C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症 ; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US20110183959A1
公开(公告)日：2011-07-28
申请号：US13013222
申请日：2011-01-25
申请人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor , Swaminathan R. Natarajan , Zhen Li , Soumya P. Sahoo
发明人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor , Swaminathan R. Natarajan , Zhen Li , Soumya P. Sahoo
IPC分类号： A61K31/506 , A61K31/4375 , C07D455/02 , A61P25/04
CPC分类号： C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US06645997B2
公开(公告)日：2003-11-11
申请号：US09961841
申请日：2001-09-24
IPC分类号： A01N4316
CPC分类号： C07D311/66
摘要： A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.
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公开(公告)号：US07319170B2
公开(公告)日：2008-01-15
申请号：US10542287
申请日：2004-01-13
申请人： Soumya P. Sahoo , Hiroo Koyama , Daniel J. Miller
发明人： Soumya P. Sahoo , Hiroo Koyama , Daniel J. Miller
IPC分类号： C07C311/16 , C07C311/19 , C07C313/06 , A61K31/64
CPC分类号： C07C317/22 , A61K45/06 , C07C311/59 , C07C2601/14
摘要： A class of N-cyclohexylaminocarbonyl benzenesulfonamide derivatives are agonists or partial agonists or antagonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
摘要翻译： 一类N-环己基氨基羰基苯磺酰胺衍生物是PPARγ的激动剂或部分激动剂或拮抗剂，可用于治疗和控制II型糖尿病症状的高血糖，以及血脂异常，高脂血症，高胆固醇血症，高甘油三酯血症和肥胖症 经常与2型糖尿病有关。
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