公开(公告)号：US10927121B1

公开(公告)日：2021-02-23

申请号：US16723215

申请日：2019-12-20

申请人： Southwest Research Institute

发明人： William R. Cantrell, Jr. ,  Robert D. Gutierrez ,  Michael J. Rubal

IPC分类号： C07D489/08

摘要： Methods for removing residual solvent from Nalmefene Hydrochloride (HCl) and producing crystalline Nalmefene HCl monohydrate, monosolvate or crystalline Nalmefene HCl dihydrate are described. In embodiments, the methods include recrystallizing Nalmefene HCl from a solvate that includes Nalmefene HCl, water, and a first solvent, wherein the first solvent has a molar volume of at least 98 cm3. Crystalline Nalmefene HCl with a desirably low amount of residual solvent is also described.

公开(公告)号：US09162983B2

公开(公告)日：2015-10-20

申请号：US14284890

申请日：2014-05-22

申请人： Southwest Research Institute

发明人： William E. Bauta ,  William R. Cantrell, Jr. ,  Michael W. Tidwell

IPC分类号： C07D215/38

CPC分类号： C07D215/38

摘要： The present invention relates to organophosphate-inhibited acetylcholinesterase (AChE) reactivators with central nervous system (CNS) bioavailability and their associated methods of preparation including their use for treatment of exposure to AChE inhibitors such as an organophosphate (OP) insecticides and nerve agents.

摘要翻译： 本发明涉及具有中枢神经系统（CNS）生物利用度的有机磷酸酯抑制乙酰胆碱酯酶（AChE）再激活剂及其相关制备方法，包括其用于治疗暴露于有机磷酸酯（OP）杀虫剂和神经药剂的AChE抑制剂的用途。