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公开(公告)号:US20140073680A1
公开(公告)日:2014-03-13
申请号:US14015829
申请日:2013-08-30
发明人: Bastiaan Nuijen , Ernie Pfadenhauer , Jos H. Beijnen , Dorla Mirejovsky , Guru Reddy , Luigi Lenaz
IPC分类号: A61K31/404 , A61K47/10
CPC分类号: A61K31/404 , A61K9/0019 , A61K9/0034 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/26
摘要: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
摘要翻译: 公开了包含吲哚醌化合物和各种膀胱癌治疗和方法的治疗组合物。 更具体地,组合物包含吲哚醌化合物和制剂载体。 制剂载体改善了吲哚醌化合物的溶解度和稳定性。 另外,涂层组合物可以包括涂层剂,其在涂层组合物的膀胱内递送期间提供涂层组合物对膀胱壁的更好的粘附。
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公开(公告)号:US09295666B2
公开(公告)日:2016-03-29
申请号:US14015829
申请日:2013-08-30
发明人: Bastiaan Nuijen , Ernie Pfadenhauer , Jos H. Beijnen , Dorla Mirejovsky , Guru Reddy , Luigi Lenaz
CPC分类号: A61K31/404 , A61K9/0019 , A61K9/0034 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/26
摘要: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
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公开(公告)号:US20140288143A1
公开(公告)日:2014-09-25
申请号:US14173734
申请日:2014-02-05
发明人: Bastiaan Nuijen , Ernie Pfadenhauer , Jos H. Beijnen , Luigi Lenaz , Shanta Chawla , Mario Beer
IPC分类号: A61K31/404 , A61K47/18 , A61K47/26 , A61K47/10 , A61K47/02
CPC分类号: A61K31/404 , A61K9/0019 , A61K9/0034 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/26
摘要: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical administration of apaziquone immediately following transurethral resection. Also disclosed are therapeutic compositions comprising an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
摘要翻译: 公开了包含吲哚醌化合物和各种膀胱癌治疗和方法的治疗组合物。 更具体地说,膀胱癌治疗包括在经尿道切除后立即施用阿哌喹酮。 还公开了包含吲哚醌化合物和制剂载体的治疗组合物。 制剂载体改善了吲哚醌化合物的溶解度和稳定性。 另外,涂层组合物可以包括涂层剂,其在涂层组合物的膀胱内递送期间提供涂层组合物对膀胱壁的更好的粘附。
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