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公开(公告)号：US07163920B2
公开(公告)日：2007-01-16
申请号：US10674516
申请日：2003-09-30
申请人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George A. Heavner , Xuanhan Lin , Chin-Feng Yi
发明人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George A. Heavner , Xuanhan Lin , Chin-Feng Yi
CPC分类号： A61K38/08 , A61K31/375 , A61K31/573 , A61K31/661 , A61K35/32 , A61K38/18 , A61K45/06 , A61L27/227 , A61K2300/00
摘要： The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.
摘要翻译： 本发明提供了包含具有成骨细胞增殖活性的分离或重组的肽组分的组合物。 促进成骨细胞增殖的肽可用于治疗骨折，作为骨缺损部位的填充物，用于抑制与骨质疏松症和牙周病相关的骨质减少，以及用于预防与骨质疏松症和类风湿性关节炎相关的骨折 。 已经经遗传工程化以产生肽的肽或细胞可以与骨相容性基质组合以促进肽缓慢释放到治疗部位和/或提供用于发展骨的结构。
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公开(公告)号：US20050187162A1
公开(公告)日：2005-08-25
申请号：US10674516
申请日：2003-09-30
申请人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George Heavner , Xuanhan Lin , Chin-Feng Yi
发明人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George Heavner , Xuanhan Lin , Chin-Feng Yi
CPC分类号： A61K38/08 , A61K31/375 , A61K31/573 , A61K31/661 , A61K35/32 , A61K38/18 , A61K45/06 , A61L27/227 , A61K2300/00
摘要： The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.
摘要翻译： 本发明提供了包含具有成骨细胞增殖活性的分离或重组的肽组分的组合物。 促进成骨细胞增殖的肽可用于治疗骨折，作为骨缺损部位的填充物，用于抑制与骨质疏松症和牙周病相关的骨质减少，以及用于预防与骨质疏松症和类风湿性关节炎相关的骨折 。 已经经遗传工程化以产生肽的肽或细胞可以与骨相容性基质组合以促进肽缓慢释放到治疗部位和/或提供用于发展骨的结构。
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