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公开(公告)号：US07459568B2
公开(公告)日：2008-12-02
申请号：US11140822
申请日：2005-05-31
IPC分类号： A61K31/381 , C07D333/36
CPC分类号： C07D333/38
摘要： Alpha crystalline form of strontium ranelate of formula (I): characterized by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in the treatment of osteoporosis and arthrosis.
摘要翻译： 式（I）的雷奈酸锶的α晶形式：其粉末X射线衍射图和含水量为22至24％的特征。 含有相同药物的药物可用于治疗骨质疏松症和关节病。
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2.发明授权γd-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it 有权盐酸伊伐布拉定的胶体结晶形式，其制备方法和含有它的药物组合物公开(公告)号：US07361651B2
公开(公告)日：2008-04-22
申请号：US11359262
申请日：2006-02-22
IPC分类号： C07D223/16 , A61K31/55 , A61P9/10
CPC分类号： C07D223/16
摘要： A γd-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
摘要翻译： 式（I）的盐酸伊伐布雷定的结晶形式：其粉末X射线衍射数据。 含有相同药物的药物可用作心动过缓药物。
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3.发明授权γ-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it 有权伊伐布雷定盐酸盐的γ-晶型，其制备方法和含有它的药物组合物公开(公告)号：US07361650B2
公开(公告)日：2008-04-22
申请号：US11358955
申请日：2006-02-22
IPC分类号： C07D223/16 , A61K31/55 , A61P9/10
CPC分类号： C07D223/16 , H04L51/12 , H04L51/14
摘要： A γ-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
摘要翻译： 式（I）的盐酸伊伐布雷定的γ-晶型：其特征在于其粉末X射线衍射数据。 含有相同药物的药物可用作心动过缓药物。
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4.发明申请Delta-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it 有权盐酸伊伐布雷达的三角晶体形式，其制备方法和含有它的药物组合物公开(公告)号：US20090318419A1
公开(公告)日：2009-12-24
申请号：US12583915
申请日：2009-08-27
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D223/16
摘要： A δ-crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data.Medicinal products containing the same which are useful as bradycardics.
摘要翻译： 式（I）的盐酸伊伐布拉定的δ-晶型：其特征在于其粉末X射线衍射数据。 含有相同药物的药物可用作心动过缓药物。
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5.发明申请Beta d-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it 有权盐酸伊伐布雷定的βd结晶形式，其制备方法和含有它的药物组合物公开(公告)号：US20090318416A1
公开(公告)日：2009-12-24
申请号：US12583857
申请日：2009-08-27
IPC分类号： A61K31/55 , C07D225/06
CPC分类号： C07D223/16 , B01J21/04 , B01J23/50 , B01J23/62 , B01J23/622 , B01J23/626 , B01J23/892 , B01J23/8926 , B01J35/0013 , B01J35/006 , B01J35/008 , B01J37/0211 , B01J37/0213 , C10G45/34
摘要： A βd-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data.Medicinal products containing the same which are useful as bradycardics.
摘要翻译： 式（I）的盐酸伊伐布拉定的betad-结晶形式：其特征在于其粉末X射线衍射数据。 含有相同药物的药物可用作心动过缓药物。
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6.发明授权βd-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it 有权盐酸伊伐布雷德的β-结晶形式，其制备方法和含有它的药物组合物公开(公告)号：US07361652B2
公开(公告)日：2008-04-22
申请号：US11359263
申请日：2006-02-22
IPC分类号： C07D223/16 , A61K31/55 , A61P9/10
CPC分类号： C07D223/16 , B01J21/04 , B01J23/50 , B01J23/62 , B01J23/622 , B01J23/626 , B01J23/892 , B01J23/8926 , B01J35/0013 , B01J35/006 , B01J35/008 , B01J37/0211 , B01J37/0213 , C10G45/34
摘要： A βd-Crystalline form of ivabradine hydrochloride of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
摘要翻译： 式（I）的盐酸伊伐布拉定的betad-结晶形式：其特征在于其粉末X射线衍射数据。 含有相同药物的药物可用作心动过缓药物。
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7.发明授权β-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it 有权盐酸伊伐布拉定的β-晶型，其制备方法和含有它的药物组合物公开(公告)号：US07361649B2
公开(公告)日：2008-04-22
申请号：US11358954
申请日：2006-02-22
IPC分类号： C07D223/16 , A61K31/55 , A61P9/10
CPC分类号： C07D223/16
摘要： A β-Crystalline form of ivabradine of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
摘要翻译： 式（I）的伊伐布拉定的β-晶型：其特征在于其粉末X射线衍射数据。 含有相同药物的药物可用作心动过缓药物。
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8.发明申请Beta-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it 有权盐酸伊伐布拉定的β-晶型，其制备方法和含有它的药物组合物公开(公告)号：US20100041640A1
公开(公告)日：2010-02-18
申请号：US12589283
申请日：2009-10-21
IPC分类号： A61K31/55 , C07D225/06
CPC分类号： C07D223/16
摘要： β-Crystalline form of ivabradine of formula (I): characterised by its powder X-ray diffraction diagram.Medicinal products containing the same which are useful as bradycardics.
摘要翻译： 式（I）的伊伐布拉定的晶型：其特征在于其粉末X射线衍射图。 含有相同药物的药物可用作心动过缓药物。
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9.发明申请Gamma d-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it 有权盐酸伊伐布雷定的γ-结晶形式，其制备方法和含有它的药物组合物公开(公告)号：US20090318420A1
公开(公告)日：2009-12-24
申请号：US12583917
申请日：2009-08-27
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D223/16
摘要： A γd-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data.Medicinal products containing the same which are useful as bradycardics.
摘要翻译： 式（I）的盐酸伊伐布雷定的结晶形式：其粉末X射线衍射数据。 含有相同药物的药物可用作心动过缓药物。
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公开(公告)号：US07250531B2
公开(公告)日：2007-07-31
申请号：US11052630
申请日：2005-02-07
申请人： Jean-Claude Souvie , Isaac Gonzalez Blanco , Gilles Thominot , Geneviève Chapuis , Stéphane Horvath , Gérard Damien
发明人： Jean-Claude Souvie , Isaac Gonzalez Blanco , Gilles Thominot , Geneviève Chapuis , Stéphane Horvath , Gérard Damien
IPC分类号： C07C233/05
CPC分类号： C07C255/37 , C07C233/18 , C07C2602/10
摘要： A process for the industrial synthesis and a new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
摘要翻译： 用于工业合成的方法和式（I）化合物的新结晶形式：含有该化合物的药物，其可用于治疗褪黑激素系统的病症。
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