专利检索 ap:("St. Jude Children's Research Hospital, Inc.") AND inv:"Jinghui ZHANG" 第 1 页

1.

发明公开
CHIMERIC ANTIGEN RECEPTORS TARGETING SPLICE VARIANTS OF THE EXTRACELLULAR MATRIX PROTEINS TENASCIN C (TNC) AND PROCOLLAGEN 11A1 (COL11A1) 审中-公开

公开(公告)号：US20240216427A1

公开(公告)日：2024-07-04

申请号：US18270675

申请日：2021-12-29

申请人： St. Jude Children's Research Hospital, Inc.

发明人： Stephen GOTTSCHALK , Jessica WAGNER , Elizabeth WICKMAN , Timothy Isham SHAW , Jinghui ZHANG

IPC分类号： A61K35/17 , A61K39/00 , A61P35/02 , C07K14/705 , C07K14/725 , C07K16/18

CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4631 , A61P35/02 , C07K14/7051 , C07K14/70521 , C07K16/18 , A61K2239/13 , A61K2239/21 , C07K2317/565 , C07K2317/622 , C07K2319/02 , C07K2319/03

摘要： The application provides chimeric antigen receptors (CARs) that target splice variants of the extracellular matrix proteins tenascin C (TNC) and procollagen 11A1 (Col11A1), and their uses in tumor immunotherapy. The application also provides polynucleotides and vectors that encode the chimeric antigen receptors, as well as host cells comprising the chimeric antigen receptors. The application also provides methods for preparing host cells comprising the chimeric antigen receptors and methods for treating patients using the modified host cells.