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公开(公告)号：US20090099266A1
公开(公告)日：2009-04-16
申请号：US12316009
申请日：2008-12-09
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.
摘要翻译： 含有烯丙胺，N，N-二（C1-C8）烷基氨基取代的（C4-C18）烷基（C2-C18）羧酸酯或其药学上可接受的酸加成盐的抗真菌指甲油组合物，亲水性聚合物和 公开了药学上可接受的挥发性有机载体。 当与真菌感染或感染的指甲接触时，组合物提供基本上水溶性的杀真菌涂层。
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公开(公告)号：US07462362B2
公开(公告)日：2008-12-09
申请号：US10514190
申请日：2004-03-22
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.
摘要翻译： 公开了一种双作用抗真菌指甲油组合物和用于改善或预防指甲真菌感染和甲真菌病的用途的方法。 公开了适用于日常杀真菌方案的单涂层型和双层型形式的组合物实施方案。 优选的抗真菌指甲涂层组合物包含有效杀真菌量的抗真菌剂，渗透促进量的基本上不挥发的渗透促进剂，成膜量的亲水性聚合物和药学上可接受的挥发性载体。 组合物在接触真菌感染或感染的指甲时提供基本上水溶性的杀真菌涂层。
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公开(公告)号：US20060067898A1
公开(公告)日：2006-03-30
申请号：US10514190
申请日：2004-03-22
申请人： Stanley Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William Pfister
发明人： Stanley Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William Pfister
IPC分类号： A61K31/137 , A61K8/41
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.
摘要翻译： 公开了一种双作用抗真菌指甲油组合物和用于改善或预防指甲真菌感染和甲真菌病的用途的方法。 公开了适用于日常杀真菌方案的单涂层型和双层型形式的组合物实施方案。 优选的抗真菌指甲涂层组合物包含有效杀真菌量的抗真菌剂，渗透促进量的基本上不挥发的渗透促进剂，成膜量的亲水性聚合物和药学上可接受的挥发性载体。 组合物在接触真菌感染或感染的指甲时提供基本上水溶性的杀真菌涂层。
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