公开(公告)号：US06561968B1

公开(公告)日：2003-05-13

申请号：US09650044

申请日：2000-08-29

申请人： Steen Dissing ,  Mogens Unden ,  Teddy Hebo Larsen ,  Soren Schou ,  Hans Nissen Petersen

发明人： Steen Dissing ,  Mogens Unden ,  Teddy Hebo Larsen ,  Soren Schou ,  Hans Nissen Petersen

IPC分类号： A61N202

CPC分类号： A61N2/02

摘要： A method for stimulating growth in biological tissue or sprouts, an apparatus and a use thereof employs fluctuating magnetic fields. The apparatus includes a pulse generator and a plurality of coils in which pulsed currents will cause fluctuating magnetic fields in a predetermined region holding the material to be stimulated. The fluctuating magnetic fields will induce an electric field in the material. An enhanced effect has been detected in the regions where the electric fields are largest. The coils include a number of pairs of coils having, during a given pulse, magnetic fields in opposite directions in order to provide field gradients in the cells, micro organisms or tissue. Selecting a suitable number, size and positioning of coils will provide a homogeneous electric field in the predetermined region, which does not have any undesirable peaked maxima. When four or more coils are used, they can be combined in pairs arranged on opposite sides of the predetermined region, and with the adjacent coils conducting current in opposite directions and the opposing coils conducting currents in the same direction. Thereby, the induced electrical fields add constructively inside the regions between the pairs of coils. In an apparatus for stimulating cell proliferation and differentiation, it is a desired feature that the generated fluctuations in the magnetic fields do not elicit action potentials of living cells since this will cause great inconvenience for the patient.

摘要翻译： 用于刺激生物组织或芽的生长的方法，其装置及其用途使用波动的磁场。 该装置包括脉冲发生器和多个线圈，其中脉冲电流将在保持待刺激的材料的预定区域中引起波动的磁场。 波动的磁场将引起材料中的电场。 在电场最大的区域中已经检测到增强的效果。 线圈包括若干对线圈，在给定的脉冲期间具有相反方向的磁场，以便在细胞，微生物或组织中提供场梯度。 选择合适的数量，尺寸和定位线圈将在预定区域内提供均匀的电场，该区域不具有任何不期望的最大峰值。 当使用四个或更多个线圈时，它们可以成对地组合成布置在预定区域的相对侧上，并且相邻线圈在相反方向上传导电流，并且相对线圈沿相同方向传导电流。 因此，感应电场在线圈对之间的区域内构建性地增加。 在用于刺激细胞增殖和分化的装置中，期望的特征是所产生的磁场波动不会引起活细胞的动作电位，因为这将对患者造成极大的不便。