公开(公告)号：US20220192973A1

公开(公告)日：2022-06-23

申请号：US17445918

申请日：2021-08-25

申请人： STEERLIFE INDIA PRIVATE LIMITED

发明人： Babu PADMANABHAN ,  Rakshit SHETTY ,  Vijay KULKARNI ,  Himadri SEN ,  Indu BHUSHAN

IPC分类号： A61K9/46 ,  A61K31/546 ,  A61K9/16 ,  A61K45/06 ,  A61K9/00 ,  A61K9/20 ,  A61K31/198 ,  A61K31/616

摘要： The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.

公开(公告)号：US20190060242A1

公开(公告)日：2019-02-28

申请号：US15766729

申请日：2016-10-07

申请人： STEERLIFE INDIA PRIVATE LIMITED

发明人： Babu PADMANABHAN ,  Himadri SEN ,  Indu BHUSHAN ,  Vijay KULKARNI ,  Rakshith SHETTY ,  Aravind Kumar GURRAM

IPC分类号： A61K9/20 ,  A61K31/403 ,  A61J3/10 ,  A61K31/4985

摘要： A rapidly disintegrating tablet comprising a therapeutically effective amount of a DPP-IV inhibitor and an acid-base couple having mineral content below the daily intake limits is disclosed. The rapidly disintegrating tablet has a sodium content less than 10 mg and a potassium content less than 15 mg. A process for preparation of the rapidly disintegrating tablet comprising the DPP-IV inhibitor is also disclosed.

公开(公告)号：US20220298020A1

公开(公告)日：2022-09-22

申请号：US17805836

申请日：2022-06-07

申请人： Steerlife India Private Limited

发明人： Indu BHUSHAN ,  Vinay RAO ,  Rakshith SHETTY

IPC分类号： C01D7/12 ,  B01J6/00

摘要： The present disclosure relates to a method for chemically modifying particles of a bicarbonate salt in a co-rotating twin-screw extruder and chemically modified bicarbonate particles prepared therefrom. The present disclosure also relates to a method for controlling an amount of carbonate salt formed during chemical modification of bicarbonate salt particles.

公开(公告)号：US20180360737A1

公开(公告)日：2018-12-20

申请号：US15781090

申请日：2016-12-12

申请人： STEERLIFE INDIA PRIVATE LIMITED

发明人： Indu BHUSHAN ,  Vijay KULKARNI ,  Rakshith SHETTY

IPC分类号： A61K9/46 ,  A61K31/155 ,  A61P3/10

摘要： The present invention relates to effervescent compositions of Metformin and optionally other anti-diabetic agents and processes for preparation thereof. More particularly provides an effervescent composition comprising Metformin, an acid and a base such that the composition is free of affirmatively added binders and granulating solvents. The effervescent composition of the present invention has retained carbon dioxide content of at least 90% of the input blend.

公开(公告)号：US20190263042A1

公开(公告)日：2019-08-29

申请号：US16373178

申请日：2019-04-02

申请人： STEERLIFE INDIA PRIVATE LIMITED

发明人： Indu BHUSHAN ,  Babu PADMANABHAN ,  Vinay RAO ,  Vijay KULKARNI ,  Chetan CHINCHOLI ,  Radhika GHIKE ,  Raja GANESHAN

IPC分类号： B29C48/40 ,  B29B9/06 ,  B29C48/57 ,  B29C48/64

摘要： Methods for granulating powder in a single piece of equipment include at least the following: (a) continuously introducing the powder and a granulating fluid to the single piece of equipment; (b) passing the powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules; (c) passing the wet granules through a drying zone of the single piece of equipment; (d) optionally passing granules through a discharge zone of the single piece of equipment; and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.

公开(公告)号：US20180214378A1

公开(公告)日：2018-08-02

申请号：US15881413

申请日：2018-01-26

申请人： STEERLIFE INDIA PRIVATE LIMITED

发明人： Indu BHUSHAN ,  Vinay RAO ,  Radhika GHIKE

IPC分类号： A61K9/16 ,  A61K31/683 ,  A61K9/20

摘要： The present invention relates to a granular composition comprising essentially Tenofovir, wherein the composition is devoid of an excipient. Tenofovir granules of the present invention are prepared in twin-screw processor such that the content of total impurities in the prepared granules is less than 2.0%.