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公开(公告)号:US20130004514A1
公开(公告)日:2013-01-03
申请号:US13490093
申请日:2012-06-06
IPC分类号: C07K16/28 , A61P37/04 , A61P29/00 , A61P19/02 , A61P11/06 , A61P1/00 , A61P1/04 , A61P9/00 , A61P25/28 , A61P37/08 , A61K39/395 , A61P3/10
CPC分类号: C07K16/2896 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要: The present invention concerns human antibodies recognising the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders.
摘要翻译: 本发明涉及识别人C5a受体的人抗体。 通过结合C5aR,抗体抑制C5a信号传导,从而抑制促炎信号。 基于C5a及其受体在炎症刺激中的作用,本发明进一步涉及所述人类抗C5aR抗体的治疗用途,特别是涉及免疫学疾病的治疗。
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公开(公告)号:US08613926B2
公开(公告)日:2013-12-24
申请号:US13490093
申请日:2012-06-06
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/2896 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要: The present invention concerns human antibodies recognizing the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders.
摘要翻译: 本发明涉及识别人C5a受体的人抗体。 通过结合C5aR,抗体抑制C5a信号传导,从而抑制促炎信号。 基于C5a及其受体在炎症刺激中的作用,本发明进一步涉及所述人类抗C5aR抗体的治疗用途,特别是涉及免疫学疾病的治疗。
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