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公开(公告)号：US07763275B2
公开(公告)日：2010-07-27
申请号：US10220590
申请日：2001-03-02
申请人： Steffen Panzner , Gerold Endert , Frank Essler , Anja Behrens , Silke Lutz , Cornelia Panzner
发明人： Steffen Panzner , Gerold Endert , Frank Essler , Anja Behrens , Silke Lutz , Cornelia Panzner
CPC分类号： A61K9/5146 , A61K9/1271 , A61K9/1272 , A61K9/5192 , B01J13/02 , B01J13/22
摘要： A method for the production of nano- or microcapsules having a diameter of from 20 nm to 40 μm is suggested, wherein template particles are supplied in an aqueous medium, electrically recharged with a polyelectrolyte, re-recharged without separation or washing steps using a second polyelectrolyte having a complementary charge with respect to the first polyelectrolyte, and said process is optionally continued with alternately charged polyelectrolytes.
摘要翻译： 建议制备直径为20nm至40μm的纳米或微胶囊的方法，其中将模板颗粒供应在水性介质中，用聚电解质进行电荷再充电，无需分离或再次充电，使用第二 聚电解质相对于第一聚电解质具有互补电荷，并且所述方法任选地连续交替加电的聚电解质。
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公开(公告)号：US20080031937A1
公开(公告)日：2008-02-07
申请号：US11745003
申请日：2007-05-07
IPC分类号： A61K9/127
CPC分类号： A61K9/0019 , A61K9/1272 , A61K48/0025
摘要： Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.
摘要翻译： 提出了两性脂质体，其包括阳性和阴性膜基膜或成膜载体以及这些脂质体的使用。
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公开(公告)号：US20110293695A1
公开(公告)日：2011-12-01
申请号：US12806342
申请日：2010-08-09
申请人： Steffen Panzner , Stefan Fankh+e,uml a+ee nel , Frank Essler , Cornelia Panzner , Gerold Endert
发明人： Steffen Panzner , Stefan Fankh+e,uml a+ee nel , Frank Essler , Cornelia Panzner , Gerold Endert
CPC分类号： A61K31/7105 , A61K9/1272 , A61K31/711 , Y10T428/2984
摘要： Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.
摘要翻译： 提出了两性脂质体，其包括阳性和阴性膜基膜或成膜载体以及这些脂质体的使用。
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公开(公告)号：US20060159737A1
公开(公告)日：2006-07-20
申请号：US11267423
申请日：2005-11-04
申请人： Steffen Panzner , Cornelia Panzner , Silke Lutz , Gerold Endert
发明人： Steffen Panzner , Cornelia Panzner , Silke Lutz , Gerold Endert
CPC分类号： A61K9/127 , A61K9/0031 , A61K9/1272 , A61K48/0025
摘要： A pharmaceutical composition for local application is disclosed, said composition comprising a nucleic acid as a therapeutic agent, an excipient and a pharmaceutically acceptable vehicle therefor, said excipient comprising a liposome. The excipient comprises an amphoteric liposome having an isoelectric point between 4 and 7.4 and said composition is formulated to have a pH in the range 3 to 5. The composition may administered in the form of a colloidal suspension and may be buffered to the lower pH at the time of use by the addition of a suitable acidifying means to a substantially neutral suspension of the nucleic acid and excipient that may be more suitable for long-term storage of the composition. Alternatively, the composition may be lyophilised at the lower pH for subsequent reconstitution just prior to use with a suitable aqueous medium, such for example as substantially unbuffered water or saline.
摘要翻译： 公开了用于局部应用的药物组合物，所述组合物包含作为治疗剂的核酸，赋形剂及其药学上可接受的载体，所述赋形剂包含脂质体。 赋形剂包含等电点在4和7.4之间的两性脂质体，所述组合物被配制成具有3至5范围内的pH。该组合物可以以胶态悬浮液的形式施用，并且可以缓冲至较低的pH值 通过将适当的酸化装置加入到可以更适合长期储存组合物的核酸和赋形剂的基本上中性的悬浮液上的使用时间。 或者，组合物可以在较低的pH下冻干，以便在使用之前用合适的水性介质，例如基本上无缓冲的水或盐水进行重组。
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公开(公告)号：US07858117B2
公开(公告)日：2010-12-28
申请号：US11745003
申请日：2007-05-07
IPC分类号： A61K9/127
CPC分类号： A61K9/0019 , A61K9/1272 , A61K48/0025
摘要： Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.
摘要翻译： 提出了两性脂质体，其包括阳性和阴性膜基膜或成膜载体以及这些脂质体的使用。
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公开(公告)号：US07780983B2
公开(公告)日：2010-08-24
申请号：US11590357
申请日：2006-10-31
IPC分类号： A61K9/127
CPC分类号： A61K31/7105 , A61K9/1272 , A61K31/711 , Y10T428/2984
摘要： Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.
摘要翻译： 提出了两性脂质体，其包括阳性和阴性膜基膜或成膜载体以及这些脂质体的使用。
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公开(公告)号：US20070269504A1
公开(公告)日：2007-11-22
申请号：US11590143
申请日：2006-10-31
IPC分类号： A61K9/127 , A61K31/7105 , A61K31/711 , C07H21/02 , C12N5/10 , C07H21/04 , B01J13/02 , A61K38/02
CPC分类号： A61K31/7105 , A61K9/1272 , A61K31/711 , Y10T428/2984
摘要： Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.
摘要翻译： 提出了两性脂质体，其包括阳性和阴性膜基膜或成膜载体以及这些脂质体的使用。
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公开(公告)号：US20070252295A1
公开(公告)日：2007-11-01
申请号：US11590357
申请日：2006-10-31
IPC分类号： B01J13/02
CPC分类号： A61K31/7105 , A61K9/1272 , A61K31/711 , Y10T428/2984
摘要： Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.
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公开(公告)号：US07371404B2
公开(公告)日：2008-05-13
申请号：US10081617
申请日：2002-02-21
IPC分类号： A61K9/127
CPC分类号： A61K31/7105 , A61K9/1272 , A61K31/711 , Y10T428/2984
摘要： Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.
摘要翻译： 提出了两性脂质体，其包括阳性和阴性膜基膜或成膜载体以及这些脂质体的使用。
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