公开(公告)号：US20220009976A1

公开(公告)日：2022-01-13

申请号：US17281862

申请日：2019-10-04

Applicant: StemRIM Inc. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Takehiko YAMAZAKI ,  Koichi YOKOTA

IPC: C07K14/47 ,  A61P1/00 ,  A61P17/00 ,  A61P9/10

Abstract: The present inventors designed an artificial sequence peptide based on the results of original research conducted so far, and found that the peptide exhibits an activity of mobilizing mesenchymal stem cells into peripheral blood. The present inventors also found that the artificial sequence peptide has a therapeutic effect on inflammatory bowel disease, atopic dermatitis, and cerebral infarction. Based on these findings, a new regenerative medicine technology that can overcome the problems of cell transplantation therapy is provided.

公开(公告)号：US20230173027A1

公开(公告)日：2023-06-08

申请号：US17919872

申请日：2021-04-19

Applicant: Shionogi & Co., Ltd. ,  StemRim Inc.

Inventor： Nao MATSUOKA ,  Shuichi HATANO ,  Yuya KUGA ,  Maki OKABE ,  Takehiko YAMAZAKI ,  Koichi YOKOTA

IPC: A61K38/19 ,  A61K47/12 ,  A61K47/26 ,  A61K47/02 ,  A61K9/19

CPC classification number: A61K38/19 ,  A61K47/12 ,  A61K47/26 ,  A61K47/02 ,  A61K9/19

Abstract: A pharmaceutical composition containing the substance according to any one of the following (a) to (c), an organic acid, a metal salt of an organic acid, and a sugar and/or a sugar alcohol, wherein when the pharmaceutical composition is dissolved in distilled water for injection, a pH of the pharmaceutical composition is 3.0 to 4.5, the substance according to any one of the following (a) to (c) can be stabilized;



(a) an HMGB1 fragment peptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or an acid addition salt thereof;
(b) a peptide comprising an amino acid sequence having substitution, deletion, insertion or addition of one or more amino acids in the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof; and
(c) a peptide comprising an amino acid sequence having about 80% or more of sequence identity to the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof.