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公开(公告)号：US5869447A
公开(公告)日：1999-02-09
申请号：US571797
申请日：1995-12-13
申请人： Stephan Henke , Birgit Jordan , Jochen Knolle , Leander Lauffer , Susanne Feiertag , Karl-Heinz Wiesmuller , Gunther Jung
发明人： Stephan Henke , Birgit Jordan , Jochen Knolle , Leander Lauffer , Susanne Feiertag , Karl-Heinz Wiesmuller , Gunther Jung
摘要： The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in whichA, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
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2.发明授权Cyclohexapeptides and their mixtures, a process for preparing them, and their use 失效环己肽及其混合物，其制备方法及其用途
公开(公告)号：US6080719A
公开(公告)日：2000-06-27
申请号：US606711
申请日：1996-02-23
申请人： Stephan Henke , Birgit Jordan , Jochen Knolle , Leander Lauffer , Susanne Feiertag , Karl-Heinz Wiesmuller , Gunther Jung
发明人： Stephan Henke , Birgit Jordan , Jochen Knolle , Leander Lauffer , Susanne Feiertag , Karl-Heinz Wiesmuller , Gunther Jung
摘要： The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in which A, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
摘要翻译： 本发明涉及式I环（ABCEF-（D）-Ala）（I）的化合物，其中A，B，C，E和F各自独立地是除半胱氨酸（Cys）和色氨酸之外的天然氨基酸的残基 （Trp），它们的混合物及其生理耐受盐; 其制备方法及其用于制备诊断剂的用途，用于治疗或预防过敏和感染的药物，或用于抑制白细胞介素-4（IL-4）与IL-4（IL-4）结合的科学工具 受体。
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