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1.发明申请Pharmaceutical composition for the prophylaxis and/or treatment of virus diseases 审中-公开用于预防和/或治疗病毒病的药物组合物公开(公告)号：US20050129694A1
公开(公告)日：2005-06-16
申请号：US10486313
申请日：2002-07-26
IPC分类号： C12N15/09 , A61K31/00 , A61K31/13 , A61K31/136 , A61K31/275 , A61K31/4439 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20 , A61P43/00 , C12Q1/02 , C12Q1/70 , A61K39/395 , A61K31/551 , A61K31/553
CPC分类号： A61K31/00 , A61K31/136 , A61K31/4439 , A61K2300/00
摘要： The invention relates to the use of at least one active substance for producing a pharmaceutical composition for the prophylaxis and/or treatment of at least one viral disease. It is characterized by active substance(s) which inhibit(s) either at least two kinases or at least one SEK kinase of a cellular signal transmission path such that virus multiplication is inhibited.
摘要翻译： 本发明涉及至少一种活性物质用于制备用于预防和/或治疗至少一种病毒性疾病的药物组合物的用途。 其特征在于抑制至少两种激酶或至少一种细胞信号传递途径的SEK激酶的活性物质，使得病毒繁殖被抑制。
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2.发明授权公开(公告)号：US08313751B2
公开(公告)日：2012-11-20
申请号：US12199694
申请日：2008-08-27
IPC分类号： A61K39/145 , A61K39/285
CPC分类号： G01N33/5008 , A61K31/00 , A61K31/13 , A61K31/19 , A61K31/335 , A61K31/35 , A61K31/40 , A61K31/54 , A61K31/60 , A61K31/70 , A61K36/82 , A61K45/06 , G01N33/5041 , Y02A50/406 , A61K2300/00
摘要： The invention relates to the use preferably of at least one active ingredient for the prophylaxis or therapy of a viral disease, wherein this active ingredient inhibits at least one component of the cellular signal transduction pathway for the activation of the transcription factor NF-kB such that virus multiplication is inhibited. The present invention relates furthermore to the local, preferably aerogenic, administration of the active ingredient according to the invention for inhibiting virus multiplication. The active ingredient according to the invention may be combined with at least one further antivirally effective substance for the prophylaxis or therapy of a viral disease.
摘要翻译： 本发明涉及优选使用至少一种活性成分用于预防或治疗病毒性疾病的用途，其中该活性成分抑制细胞信号转导途径的至少一个组分用于激活转录因子NF-kB，使得 病毒繁殖被抑制。 本发明进一步涉及根据本发明的用于抑制病毒增殖的局部优选生气发生的给药。 根据本发明的活性成分可与至少一种另外的抗病毒有效物质组合以预防或治疗病毒性疾病。
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3.发明申请公开(公告)号：US20090191207A1
公开(公告)日：2009-07-30
申请号：US12199694
申请日：2008-08-27
IPC分类号： A61K39/395 , C12Q1/70 , A61K31/192 , A61K31/60 , A61K31/40 , A61K31/355 , A61K31/5415 , A61K31/353 , A61K38/16 , A61K31/7105
CPC分类号： G01N33/5008 , A61K31/00 , A61K31/13 , A61K31/19 , A61K31/335 , A61K31/35 , A61K31/40 , A61K31/54 , A61K31/60 , A61K31/70 , A61K36/82 , A61K45/06 , G01N33/5041 , Y02A50/406 , A61K2300/00
摘要： The invention relates to the use preferably of at least one active ingredient for the prophylaxis or therapy of a viral disease, wherein this active ingredient inhibits at least one component of the cellular signal transduction pathway for the activation of the transcription factor NF-kB such that virus multiplication is inhibited. The present invention relates furthermore to the local, preferably aerogenic, administration of the active ingredient according to the invention for inhibiting virus multiplication. The active ingredient according to the invention may be combined with at least one further antivirally effective substance for the prophylaxis or therapy of a viral disease.
摘要翻译： 本发明涉及优选使用至少一种活性成分用于预防或治疗病毒性疾病的用途，其中该活性成分抑制细胞信号转导途径的至少一个组分用于激活转录因子NF-kB，使得 病毒繁殖被抑制。 本发明进一步涉及根据本发明的用于抑制病毒增殖的局部优选生气发生的给药。 根据本发明的活性成分可与至少一种另外的抗病毒有效物质组合以预防或治疗病毒性疾病。
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4.发明申请PHARMACEUTICAL COMPOSITION FOR THE PROPHYLAXIS AND/OR TREATMENT OF VIRAL DISEASES 审中-公开预防和/或治疗病毒性疾病的药物组合物公开(公告)号：US20100239563A1
公开(公告)日：2010-09-23
申请号：US12343461
申请日：2008-12-23
IPC分类号： A61K39/395 , C12Q1/70 , A61K31/7056 , A61K31/713 , A61K31/7088 , A61K31/553 , A61K31/55 , A61K31/52 , A61K31/437 , A61K31/4439 , A61K31/343 , A61K31/13 , A61K31/122 , A61P31/12
CPC分类号： A61K31/00 , A61K31/136 , A61K31/4439 , A61K2300/00
摘要： The invention relates to the use of at least one active substance for producing a pharmaceutical composition for the prophylaxis and/or treatment of at least one viral disease. It is characterized by active substance(s) which inhibit(s) either at least two kinases or at least one SEK kinase of a cellular signal transmission path such that virus multiplication is inhibited.
摘要翻译： 本发明涉及至少一种活性物质用于制备用于预防和/或治疗至少一种病毒性疾病的药物组合物的用途。 其特征在于抑制至少两种激酶或至少一种细胞信号传递途径的SEK激酶的活性物质，使得病毒繁殖被抑制。
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5.发明申请USE OF SUBSTANCES THAT ACT AS CASCADE INHIBITORS OF THE RAF/MEK/ERK SIGNAL CASCADE, FOR PRODUCING A MEDICAMENT TO TREAT DNA AND RNA VIRUSES 审中-公开使用作为RAF / MEK / ERK信号CASCADE的CASCADE抑制剂的物质，用于生产用于治疗DNA和RNA病毒的药物公开(公告)号：US20100137431A1
公开(公告)日：2010-06-03
申请号：US12470441
申请日：2009-05-21
申请人： Stephan Ludwig , Stephan Pleschka
发明人： Stephan Ludwig , Stephan Pleschka
IPC分类号： A61K31/277 , A61P31/14 , A61P31/16
CPC分类号： A61K31/352 , A61K31/145 , A61K31/166
摘要： The invention consists in that substances acting as cascade inhibitors of the Raf/MEK/ERK signaling pathway, in particular MEK inhibitors, are used for the production of a drug for the preventive and antiviral therapy against DNA and RNA viruses, in particular against intranuclear-replicating negative strand RNA viruses, for instance influenza or Borna disease viruses.
摘要翻译： 本发明包括作为Raf / MEK / ERK信号通路的级联抑制剂的物质，特别是MEK抑制剂，用于生产用于预防和抗病毒治疗的药物，用于针对DNA和RNA病毒，特别是针对核内 - 复制负链RNA病毒，例如流感或博尔那病毒。
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6.发明申请Use of active ingredients for the prophylaxis and/or therapy of viral diseases 审中-公开使用活性成分预防和/或治疗病毒性疾病公开(公告)号：US20060247161A1
公开(公告)日：2006-11-02
申请号：US10541633
申请日：2004-01-02
IPC分类号： A61K38/16 , A61K31/7056 , A61K31/7048 , A61K31/63 , A61K31/60 , A61K31/56 , A61K31/401 , A61K31/13 , A61K31/355 , A61K31/353
CPC分类号： G01N33/5008 , A61K31/00 , A61K31/13 , A61K31/19 , A61K31/335 , A61K31/35 , A61K31/40 , A61K31/54 , A61K31/60 , A61K31/70 , A61K36/82 , A61K45/06 , G01N33/5041 , A61K2300/00
摘要： The invention relates to the use preferably of at least one active ingredient for the prophylaxis and/or therapy of a viral disease, wherein this active ingredient inhibits at least one component of the cellular signal transduction pathway for the activation of the transcription factor NF-kB such that the virus multiplication is inhibited. The present invention relates furthermore to the local, preferably aerogenic administration of the active ingredient according to the invention for inhibiting a virus multiplication. The active ingredient according to the invention may be combined with at least one further antivirally effective substance for the prophylaxis and/or therapy of a viral disease.
摘要翻译： 本发明涉及优选使用至少一种活性成分用于预防和/或治疗病毒性疾病的用途，其中该活性成分抑制细胞信号转导途径的至少一种成分用于激活转录因子NF-kB 使得病毒繁殖被抑制。 本发明进一步涉及根据本发明的用于抑制病毒繁殖的局部优选产生生成剂。 根据本发明的活性成分可以与至少一种另外的抗病毒有效物质组合，用于预防和/或治疗病毒性疾病。
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7.发明申请Application of substances acting as cascade inhibitors of the Raf/MEK/ERK signaling cascade for the production of a drug against DNA and RNA viruses 审中-公开作为Raf / MEK / ERK信号级联的级联抑制剂的物质用于生产针对DNA和RNA病毒的药物的应用公开(公告)号：US20050215627A1
公开(公告)日：2005-09-29
申请号：US10970118
申请日：2004-10-21
申请人： Stephan Ludwig , Stephan Pleschka
发明人： Stephan Ludwig , Stephan Pleschka
IPC分类号： C07D311/32 , A61K31/145 , A61K31/166 , A61K31/275 , A61K31/352 , A61K31/353 , A61K45/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20 , A61K31/343 , A61K31/137 , A61K31/165
CPC分类号： A61K31/352 , A61K31/145 , A61K31/166
摘要： The invention consists in that substances acting as cascade inhibitors of the Raf/MEK/ERK signaling pathway, in particular MEK inhibitors, are used for the production of a drug for the preventive and antiviral therapy against DNA and RNA viruses, in particular against intranuclear-replicating negative strand RNA viruses, for instance influenza or Borna disease viruses.
摘要翻译： 本发明包括作为Raf / MEK / ERK信号通路的级联抑制剂的物质，特别是MEK抑制剂，用于生产用于预防和抗病毒治疗的药物，用于针对DNA和RNA病毒，特别是针对核内 - 复制负链RNA病毒，例如流感或博尔那病毒。
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公开(公告)号：US20150224103A1
公开(公告)日：2015-08-13
申请号：US14434328
申请日：2013-10-08
发明人： Stephan Pleschka , Oliver Planz , Stephan Ludwig
IPC分类号： A61K31/535 , A61K31/4184 , A61K31/4412 , A61K31/44 , A61K31/245 , A61K31/18 , A61K31/506 , A61K31/185 , A61K31/4458 , A61K31/353 , A61K31/4375 , A61K31/519
CPC分类号： A61K31/519 , A61K31/166 , A61K31/18 , A61K31/185 , A61K31/215 , A61K31/245 , A61K31/325 , A61K31/353 , A61K31/4184 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4458 , A61K31/506 , A61K31/52 , A61K31/535 , A61K45/06 , A61K2300/00
摘要： The present invention relates to MEK inhibitors that are capable of displaying one or more beneficial therapeutic effects. The MEK inhibitors can be used in the prevention and/or treatment of viral infection. MEK inhibitors in combination with neuraminidase inhibitor compounds are capable of displaying one or more beneficial therapeutic effects in the treatment of viral diseases.
摘要翻译： 本发明涉及能够显示一种或多种有益治疗效果的MEK抑制剂。 MEK抑制剂可用于预防和/或治疗病毒感染。 与神经氨酸酶抑制剂化合物组合的MEK抑制剂能够在治疗病毒性疾病中显示一种或多种有益的治疗效果。
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公开(公告)号：US09566281B2
公开(公告)日：2017-02-14
申请号：US14434328
申请日：2013-10-08
发明人： Stephan Pleschka , Oliver Planz , Stephan Ludwig
IPC分类号： A61K31/195 , A61K31/35 , A61K31/24 , A61K31/519 , A61K31/415 , A61K31/215 , A61K31/44 , A61K31/425 , A61K31/535 , A61K45/06 , A61K31/325 , A61K31/437 , A61K31/4458 , A61K31/52 , A61K31/18 , A61K31/185 , A61K31/245 , A61K31/353 , A61K31/4184 , A61K31/4375 , A61K31/4412 , A61K31/506
CPC分类号： A61K31/519 , A61K31/166 , A61K31/18 , A61K31/185 , A61K31/215 , A61K31/245 , A61K31/325 , A61K31/353 , A61K31/4184 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4458 , A61K31/506 , A61K31/52 , A61K31/535 , A61K45/06 , A61K2300/00
摘要： The present invention relates to MEK inhibitors that are capable of displaying one or more beneficial therapeutic effects. The MEK inhibitors can be used in the prevention and/or treatment of viral infection. MEK inhibitors in combination with neuraminidase inhibitor compounds are capable of displaying one or more beneficial therapeutic effects in the treatment of viral diseases.
摘要翻译： 本发明涉及能够显示一种或多种有益治疗效果的MEK抑制剂。 MEK抑制剂可用于预防和/或治疗病毒感染。 与神经氨酸酶抑制剂化合物组合的MEK抑制剂能够在治疗病毒性疾病中显示一种或多种有益的治疗效果。
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10.发明申请CASPASE INHIBITORS, ESPECIALLY CASPASE 3 INHIBITORS, FOR THE TREATMENT OF INFLUENZA 审中-公开CASPASE INHIBITORS，特别是CASPASE 3抑制剂，用于治疗流感公开(公告)号：US20090155270A1
公开(公告)日：2009-06-18
申请号：US12331864
申请日：2008-12-10
IPC分类号： A61K39/395 , A61K38/16 , C12N5/10 , C12Q1/68 , A61P37/04
CPC分类号： C07K14/81
摘要： The invention relates to the use of at least one caspase inhibitor, in particular a caspase-3 inhibitor, for preparing a pharmaceutical composition for the prophylaxis or therapy of a viral infection, in particular an infection with an RNA negative-strand virus, preferably an influenza infection, and to a test system for identifying suitable active substances.
摘要翻译： 本发明涉及至少一种半胱天冬酶抑制剂，特别是胱天蛋白酶-3抑制剂用于制备用于预防或治疗病毒感染的药物组合物的用途，特别是RNA负链病毒的感染，优选为 流感感染，以及用于鉴定合适活性物质的测试系统。
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