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公开(公告)号：US07538114B2
公开(公告)日：2009-05-26
申请号：US11823027
申请日：2007-06-26
IPC分类号： A61K31/4965 , A01N43/62 , A61K31/55 , A01N43/00 , A61K31/33 , C07D243/08 , C07D245/00 , C07D241/04 , C07D295/00
CPC分类号： C07D241/04 , A61K31/495 , A61K31/551 , A61K33/00 , C07D213/36 , C07D241/08 , C07D243/08 , C07D295/15 , C07D333/20
摘要： The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译： 本发明提供了作为甘氨酸转运蛋白1（以下称为GlyT-1）抑制剂的化合物，因此可用于治疗通过抑制GlyT1可治疗的疾病，例如与精神分裂症，ADHD（注意缺陷多动障碍）相关的认知障碍， MCI（轻度认知障碍）等。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US20120195985A1
公开(公告)日：2012-08-02
申请号：US13426539
申请日：2012-03-21
IPC分类号： A61K33/00 , A61P25/18 , A61P25/24 , A61P25/22 , A61P25/00 , A61P25/28 , A61P25/16 , A61P15/00 , A61P21/00 , A61P27/16 , A61K31/496 , A61K31/551 , A61K31/5517 , A61K31/55 , A61K31/495
CPC分类号： C07D241/04 , A61K31/495 , A61K31/551 , A61K33/00 , C07D213/36 , C07D241/08 , C07D243/08 , C07D295/15 , C07D333/20
摘要： The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT-1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译： 本发明提供了甘氨酸转运蛋白1（以下称为GlyT-1）抑制剂的化合物，因此可用于治疗通过抑制GlyT-1治疗的疾病，例如与精神分裂症，ADHD（注意缺陷多动障碍 ），MCI（轻度认知障碍）等。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US08183244B2
公开(公告)日：2012-05-22
申请号：US12464697
申请日：2009-05-12
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号： C07D241/04 , A61K31/495 , A61K31/551 , A61K33/00 , C07D213/36 , C07D241/08 , C07D243/08 , C07D295/15 , C07D333/20
摘要： The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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公开(公告)号：US20090227595A1
公开(公告)日：2009-09-10
申请号：US12464697
申请日：2009-05-12
IPC分类号： A61K31/5513 , A61K31/4965 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/24 , A61P29/00 , A61K31/496
CPC分类号： C07D241/04 , A61K31/495 , A61K31/551 , A61K33/00 , C07D213/36 , C07D241/08 , C07D243/08 , C07D295/15 , C07D333/20
摘要： The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译： 本发明提供了作为甘氨酸转运蛋白1（以下称为GlyT-1）抑制剂的化合物，因此可用于治疗通过抑制GlyT1可治疗的疾病，例如与精神分裂症，ADHD（注意缺陷多动障碍）相关的认知障碍， MCI（轻度认知障碍）等。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US08735383B2
公开(公告)日：2014-05-27
申请号：US13426539
申请日：2012-03-21
IPC分类号： A01N43/00 , A01N43/62 , A61K31/33 , A61K31/55 , A61K31/4965 , A61K31/495 , A61K31/551 , A61K33/00
CPC分类号： C07D241/04 , A61K31/495 , A61K31/551 , A61K33/00 , C07D213/36 , C07D241/08 , C07D243/08 , C07D295/15 , C07D333/20
摘要： The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT-1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译： 本发明提供了甘氨酸转运蛋白1（以下称为GlyT-1）抑制剂的化合物，因此可用于治疗通过抑制GlyT-1治疗的疾病，例如与精神分裂症，ADHD（注意缺陷多动障碍 ），MCI（轻度认知障碍）等。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US20080004289A1
公开(公告)日：2008-01-03
申请号：US11823027
申请日：2007-06-26
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D241/04 , A61K31/495 , A61K31/551 , A61K33/00 , C07D213/36 , C07D241/08 , C07D243/08 , C07D295/15 , C07D333/20
摘要： The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译： 本发明提供了作为甘氨酸转运蛋白1（以下称为GlyT-1）抑制剂的化合物，因此可用于治疗通过抑制GlyT1可治疗的疾病，例如与精神分裂症，ADHD（注意缺陷多动障碍）相关的认知障碍， MCI（轻度认知障碍）等。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
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