摘要:
Aspects of this invention are related, at least in part, to the use of chemical compounds able to inhibit GSK-3 and/or to stabilize β-catenin and formulations thereof. Some aspects of this invention relate to compositions comprising such compounds. Some aspects of the invention provide methods of using such compounds and/or compositions in the treatment of subjects having a neurological disease and/or psychiatric disorder. Some aspects of this invention provide methods of using ruboxistaurin, enzastaurin, sunitinib, midostaurin, lestaurtinib, 7-hydroxystaurosporine, and/or Chir99021 in the treatment of subjects having a neurological disease and/or psychiatric disorder. In some embodiments, compounds are administered in combination with Lithium.
摘要:
Aspects of this invention are related, at least in part, to the use of chemical compounds able to inhibit GSK-3 and/or to stabilize β-catenin and formulations thereof. Some aspects of this invention relate to compositions comprising such compounds. Some aspects of the invention provide methods of using such compounds and/or compositions in the treatment of subjects having a neurological disease and/or psychiatric disorder. Some aspects of this invention provide methods of using ruboxistaurin, enzastaurin, sunitinib, midostaurin, lestaurtinib, 7-hydroxystaurosporine, and/or Chir99021 in the treatment of subjects having a neurological disease and/or psychiatric disorder. In some embodiments, compounds are administered in combination with Lithium.
摘要:
The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer.
摘要:
A method and system for sorting a number of items in a computer system. The sort is based on a plurality of values of a key. Each item has a value of the plurality of values. The method and system include providing plurality of stages, providing at least one switch coupled between the plurality of stages, and providing a final switch coupled with a last stage. Each of the plurality of stages has a pair of first-in-first-out buffers (FIFOs) that store twice as many of the items as the pair of FIFOs in a previous stage. Each switch is for merging and sorting a first portion of the number of items from the pair of FIFOs in the previous stage based on the key and for providing the first portion of the number plurality of items to a first FIFO of the pair of FIFOs of the stage in order. Each switch is also for merging and sorting a second portion of the number of items the pair of FIFOs in the previous stage based on the key and providing the second portion of the number plurality of items to a second FIFO of the pair of FIFOs of the stage in order. The last switch is for merging and sorting a third portion of the number of items to provide the number of items in order.
摘要:
A method and system for providing a graphical image on a display is disclosed. The display includes a plurality of pixels. The data includes a plurality of fragments for the at least one object. The plurality of fragments intersects a portion of the plurality of pixels. The method and system include defining a plurality of macro-pixels. Each of the plurality of macro-pixels includes a second portion of the plurality of pixels. The second portion of the plurality of pixels are adjacent and include n pixels of the second portion of the plurality of pixels in a first direction and m pixels of the second portion of the plurality of pixels in a second direction. The method and system further include rendering the plurality of pixels by rendering a plurality of macro-pixels in raster order. In one aspect, each macro-pixel is rendered by rendering the second portion of the plurality of pixels pixel by pixel. Each of the second portion of the plurality of pixels is rendered by rendering the fragments intersecting the pixel. In another aspect, each macro-pixel is rendered by rendering macro-fragments intersecting the macro-pixel. Each macro-fragment intersecting a macro-pixel includes the fragments for a particular polygon that intersect the macro-pixel. The data is then output pixel by pixel. An output for each pixel includes a first portion of the plurality of fragments that intersect the pixel.
摘要:
A system and method for providing a sort in a computer system is disclosed. The sort is based on a plurality of values of a key. Each of the plurality of items has an associated value of the plurality of values. The method and system include providing a new item of the plurality of items to a plurality of sort cells. The new item includes a new value of the plurality of values. The plurality of sort cells is for sorting the plurality of items. Each sort cell is for sorting a corresponding item of the plurality of items. The corresponding item has a corresponding value of the plurality of values. The method and system further include comparing the new value to the corresponding value for each of the plurality of sort cells to determine whether to retain the corresponding item. Each of the plurality of sort cells retains the corresponding item if the corresponding item is to be retained. For each of the plurality of sort cells, the method and system determine whether to accept the new item or an item corresponding to the previous sort cell if the corresponding item is not to be retained. If the corresponding item is not to be retained, the method and system allow a sort cell to accept the new item or the item corresponding to the previous sort cell.
摘要:
A system and method for providing antialiasing of a graphical image on a display is disclosed. The graphical image is generated from data describing at least one object. The display includes a plurality of pixels. The at least one object includes a plurality of fragments. A portion of the plurality of fragments intersects a pixel of the plurality of pixels. Each of the plurality of fragments including an indication of a portion of a corresponding pixel that is intersected. The system and method include providing at least one active region for the pixel. The at least one active region intersects a first portion of the pixel. The method and system also include providing at least one new region. A first portion of the at least one new region indicates where in the pixel the at least one active region and the fragment intersect. A second portion of the at least one new region indicates where in the pixel the at least one active region and the fragment do not intersect. The method and system further include blending a portion of the fragment in a second portion of the pixel corresponding to the first portion of the at least one new region.
摘要:
A method and system for providing antialiasing of a graphical image on a display from data describing at least one object is disclosed. The display includes a plurality of pixels. The method and system include providing a plurality of fragments for the at least one object. A portion of the plurality of fragments intersects a pixel of the plurality of pixels. Each of the plurality of fragments includes a depth value, a slope of the depth value, and an indication of a portion of a corresponding pixel that is intersected. The method and system include calculating a plurality of subpixel depth values for a fragment of the plurality of fragments. The plurality of subpixel depth values is calculated using the depth value and the slope of the depth value of the fragment. The method and system include determining whether to store a portion of the fragment based on the plurality of subpixel depth values for the fragment and the indication of the extent the corresponding pixel is intersected by the fragment. The method and system also include storing the portion of the fragment if it has been determined that the portion of the fragment is to be stored. The method and system also include repeating the calculating, determining, and storing steps for each remaining fragment in the portion of the plurality of fragments. The method and system also include providing antialiased data for the pixel based on a second portion of the plurality of fragments that have been stored.
摘要:
A system and method for generating a graphical display from data describing at least one three-dimensional object is disclosed. The system method and system include providing a rasterizer for rendering the data in an order. The rasterizer includes a plurality of processors, each of the plurality of processors for receiving a portion of the data, determining if a current position is located within the portion of the data, and providing an output if the current position is located within the portion of the data. The rasterizer further includes a single interpolator coupled to the plurality of processors. The single interpolator is configured such that in response to the output, the single interpolator provides information relating to a plurality of characteristics of the portion of the data in the processor providing the output.
摘要:
A system and method for providing antialiasing of a graphical image on a display is disclosed. The graphical image is generated from data describing at least one object. The display includes a plurality of pixels. The at least one object includes a plurality of fragments. A portion of the plurality of fragments intersects a pixel of the plurality of pixels. Each of the plurality of fragments including an indication of a portion of a corresponding pixel that is intersected. The system and method include providing at least one active region for the pixel. The at least one active region intersects a first portion of the pixel. The method and system also include providing at least one new region. A first portion of the at least one new region indicates where in the pixel the at least one active region and the fragment intersect. A second portion of the at least one new region indicates where in the pixel the at least one active region and the fragment do not intersect. The method and system further include blending a portion of the fragment in a second portion of the pixel corresponding to the first portion of the at least one new region.