公开(公告)号：US20090111120A1

公开(公告)日：2009-04-30

申请号：US12295626

申请日：2007-03-30

申请人： Stephen J. Meltzer ,  Zhe Jin ,  Fumiaki Sato ,  Bogdan Constantin Paun

发明人： Stephen J. Meltzer ,  Zhe Jin ,  Fumiaki Sato ,  Bogdan Constantin Paun

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

摘要： The present invention provides methods for identifying or assessing probabilities for developing an abnormal condition in subject and for the recurrence of the abnormal condition in the subject after receiving treatment. The method comprises determining the methylation status of at least one gene in the subject and comparing this methylation status to normal methylation status. Differences between the methylation status of the one or more genes is indicative of the subject developing an abnormal condition or for the recurrence of the abnormal conditions after receiving treatment.

摘要翻译： 本发明提供了用于鉴定或评估在接受治疗后在受试者中发展异常状况和异常状况复发的概率的方法。 该方法包括确定受试者中至少一个基因的甲基化状态，并将该甲基化状态与正常甲基化状态进行比较。 一个或多个基因的甲基化状态之间的差异指示受试者在接受治疗后发展异常状况或异常状况的复发。