公开(公告)号：US20210362255A1

公开(公告)日：2021-11-25

申请号：US17395196

申请日：2021-08-05

Applicant: Stephen MacLennan

Inventor： Stephen MacLennan

IPC: B23D61/04 ,  B27B33/08 ,  A01G23/091

Abstract: The present disclosure concerns a saw tooth holder for a cutting disk of a rotary cutting machine. The saw tooth holder comprises a holder body having a tooth-receiving surface abuttable against a rear surface of a saw tooth of a tooth assembly and a trailing surface, opposed to the tooth-receiving surface, and defining a trailing oblique angle with respect to the tooth-receiving surface. The holder body has a fastener-receiving aperture extending therethrough between the tooth-receiving surface and the trailing surface and being accessible from the tooth-receiving surface and the trailing surface. The present disclosure also concerns a cutting disk comprising such a saw tooth holder, a saw tooth holder in combination with a tooth assembly, and a rotary cutting machine comprising such a cutting disk.

公开(公告)号：US10272508B2

公开(公告)日：2019-04-30

申请号：US15088371

申请日：2016-04-01

Applicant: Stephen MacLennan

Inventor： Stephen MacLennan

IPC: B23D61/02 ,  B23D61/06 ,  B27B33/08

Abstract: A saw tooth including a body defining substantially opposed rear and front ends and an axial centerline extending between the rear and front ends, the body defining side faces joined to each other by body edge sections, each side face and each body edge section extending between the rear and front ends; edge cutting tips extending from the body at the front end and facing the direction of advance, each edge cutting tip being in prolongation of a respective one of the body edge sections; and side cutting tips extending from the body and facing the direction of advance, each of the side cutting tips being provided at the front end between two adjacent ones of the edge cutting tips in prolongation of a respective one of the side faces.

公开(公告)号：US10675695B2

公开(公告)日：2020-06-09

申请号：US15088311

申请日：2016-04-01

Applicant: Stephen MacLennan

Inventor： Stephen MacLennan

IPC: B23D61/02 ,  B27B33/08 ,  B23D61/06

Abstract: A saw tooth mountable to a circular saw disc and including a body defining rear and front ends. In operation, the front end leads the rear end as the saw disc turns. A cutting tip extends from the body and defines a cutting tip base adjacent to the body and an opposed cutting edge. The cutting tip base is rearwardly provided relative to the cutting edge. An elongated gullet extends along the cutting tip substantially adjacent to the cutting tip base and defines opposed gullet first and second ends and a gullet longitudinal axis therebetween. A gullet nadir line extends longitudinally between the gullet first and second ends and joins locations along the gullet that are closest to the rear end at all longitudinal positions along the gullet. The gullet nadir line is closer to the rear end at the gullet first end than at the gullet second end.

公开(公告)号：US20060204502A1

公开(公告)日：2006-09-14

申请号：US11286127

申请日：2005-11-22

Applicant: Pier Borea ,  Pier Baraldi ,  Stefania Merighi ,  Stephen MacLennan ,  Edward Leung ,  Allan Moorman

Inventor： Pier Borea ,  Pier Baraldi ,  Stefania Merighi ,  Stephen MacLennan ,  Edward Leung ,  Allan Moorman

IPC: A61K39/395 ,  A61K31/519

CPC classification number: A61K31/7076 ,  A61K31/519 ,  C07D487/04 ,  C07D487/14 ,  C07K16/18

Abstract: The present invention relates to the use of adenosine receptor antagonists, preferably A3 receptor antagonists, either alone or in combination with other agents for the treatment, prevention and/or management of diseases or disorders associated with overexpression of HIF-1α and/or increased HIF-1α activity (e.g., cancer, respiratory disease). The methods and compositions of the invention are particularly useful for preventing, treating, or ameliorating symptoms associated with a cancer, disease or disorder associated with hypoxia-inducible factor 1α (HIF-1α) using the A3 receptor antagonists of the invention. The present invention provides methods to inhibit the growth of tumors, particularly solid tumors and more particularly hypoxic tumors.

Abstract translation: 本发明涉及腺苷受体拮抗剂，优选Aβ3受体拮抗剂，其单独使用或与其它药物组合用于治疗，预防和/或控制与过表达相关的疾病或病症 HIF-1α和/或增加的HIF-1α活性（如癌症，呼吸系统疾病）。 本发明的方法和组合物特别可用于预防，治疗或改善与使用Aβ受体相关的与缺氧诱导因子1α（HIF-1α）相关的癌症，疾病或病症相关症状。 本发明的拮抗剂。 本发明提供抑制肿瘤，特别是实体瘤，特别是缺氧性肿瘤生长的方法。

公开(公告)号：US20060194756A1

公开(公告)日：2006-08-31

申请号：US11286129

申请日：2005-11-22

Applicant: Pier Borea ,  Pier Baraldi ,  Stefania Merighi ,  Stephen MacLennan ,  Edward Leung ,  Allan Moorman

Inventor： Pier Borea ,  Pier Baraldi ,  Stefania Merighi ,  Stephen MacLennan ,  Edward Leung ,  Allan Moorman

IPC: A61K31/7076

CPC classification number: A61K31/7076 ,  A61K31/519 ,  C07D487/04 ,  C07D487/14 ,  C07K16/18

Abstract: The present invention relates to the use of adenosine receptor agonists, preferably A3 receptor agonists, either alone or in combination with other agents for the treatment, prevention and/or management of diseases or disorders associated with under-expression of HIF-1α and/or decreased HIF-1 α activity (e.g., ischemic related disorders). The methods of the invention are directed to methods of reducing tissue damage (e.g., substantially prevention tissue damage, inducing tissue protection) resulting from ischemia orhypoxia. The invention provides methods for treating, preventing and/or ameliorating one or more symptoms of hypoxic or HIF-1α related disorders by administering an A3 receptor agonist either alone or in combination with other agents.

Abstract translation: 本发明涉及腺苷受体激动剂，优选A 3 N 3受体激动剂，单独使用或与其它药剂组合用于治疗，预防和/或控制与低血糖相关的疾病或病症， HIF-1α的表达和/或降低的HIF-1α活性（例如缺血性相关疾病）。 本发明的方法涉及减少由局部缺血或缺氧引起的组织损伤（例如，基本上预防组织损伤，诱导组织保护）的方法。 本发明提供了通过单独或与其它药剂组合施用A 3 O 3受体激动剂来治疗，预防和/或改善一种或多种缺氧或HIF-1α相关疾病症状的方法。