-
公开(公告)号：US07803760B2
公开(公告)日：2010-09-28
申请号：US12106882
申请日：2008-04-21
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
-
公开(公告)号：US07364910B2
公开(公告)日：2008-04-29
申请号：US11456033
申请日：2006-07-06
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
-
3.发明授权公开(公告)号：US07507707B2
公开(公告)日：2009-03-24
申请号：US10498639
申请日：2001-12-14
申请人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
发明人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
IPC分类号： A61K31/00
CPC分类号： A61K31/437 , A61K31/00 , A61K31/138 , A61K31/277 , A61K31/352 , A61K31/4196 , A61K31/44 , A61K31/4535 , A61K31/502 , A61K31/519 , A61K31/522 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
-
公开(公告)号：US07078236B2
公开(公告)日：2006-07-18
申请号：US11169183
申请日：2005-06-28
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
-
公开(公告)号：US06953774B2
公开(公告)日：2005-10-11
申请号：US10014812
申请日：2001-12-14
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K31/00 , A61K31/137 , A61K38/24
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase type 4.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是4型磷酸二酯酶抑制剂。
-
公开(公告)号：US07153824B2
公开(公告)日：2006-12-26
申请号：US10817312
申请日：2004-04-01
申请人： Stephen S. Palmer , Sean D. McKenna , Stephen J. Arkinstall , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen S. Palmer , Sean D. McKenna , Stephen J. Arkinstall , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K31/00
CPC分类号： A61K45/06 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61K38/09 , A61K38/24 , A61K2300/00
摘要： The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation using a PDE inhibitor. The inhibitor may be used alone at high doses. Alternatively, the follicular maturation is achieved by combining a low dose of FSH with the PDE inhibitor treatment.
摘要翻译： 本发明涉及增加哺乳动物卵母细胞产生的方法。 更具体地，说明书描述了使用PDE抑制剂诱导滤泡成熟的方法和组合物。 抑制剂可以高剂量单独使用。 或者，通过将低剂量FSH与PDE抑制剂治疗组合来实现滤泡成熟。
-
公开(公告)号：US20080213889A1
公开(公告)日：2008-09-04
申请号：US11938059
申请日：2007-11-09
申请人： Stephen S. Palmer , Sean D. McKenna , Stephen J. Arkinstall , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen S. Palmer , Sean D. McKenna , Stephen J. Arkinstall , Aliza Eshkol , Michael C. MacNamee
IPC分类号： C12N5/02
CPC分类号： A61K45/06 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61K38/09 , A61K38/24 , A61K2300/00
摘要： The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation using a PDE inhibitor. The inhibitor may be used alone at high doses. Alternatively, the follicular maturation is achieved by combining a low dose of FSH with the PDE inhibitor treatment.
摘要翻译： 本发明涉及增加哺乳动物卵母细胞产生的方法。 更具体地，说明书描述了使用PDE抑制剂诱导滤泡成熟的方法和组合物。 抑制剂可以高剂量单独使用。 或者，通过将低剂量FSH与PDE抑制剂治疗组合来实现滤泡成熟。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.032 秒)
