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公开(公告)号：US07341737B2
公开(公告)日：2008-03-11
申请号：US10335759
申请日：2002-12-31
申请人： Steven Craig Gehling , Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Chris Clendening , Giovanni M. Pauletti
发明人： Steven Craig Gehling , Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Chris Clendening , Giovanni M. Pauletti
CPC分类号： A61M31/00 , A61F13/202 , A61F13/2051 , A61F13/2074 , A61F13/28 , A61F13/8405 , A61F2013/8414 , A61F2013/8417 , A61K9/0036 , A61K9/025 , A61M2210/1475 , Y10S514/966 , Y10S514/967
摘要： A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body having a distal end; and a dosage form affixed to the distal end of the tampon body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form comprises a plurality of layers. Also, a method for manufacturing a medicated tampon adapted to deliver a therapeutic agent, the method including manufacturing a tampon body having a distal end; producing a dosage form having a plurality of layers, wherein the dosage form includes a formulation including a therapeutic agent; and affixing the dosage form to the distal end of the tampon body.
摘要翻译： 一种适于递送治疗剂的卫生棉条，所述棉塞包括具有远端的棉塞本体; 以及固定在卫生栓体的远端的剂型，其中所述剂型包括包含治疗剂的制剂，并且其中所述剂型包含多个层。 另外，一种适于输送治疗剂的药物棉塞的制造方法，其特征在于，包括制造具有前端的棉塞体; 制备具有多个层的剂型，其中所述剂型包括包含治疗剂的制剂; 并将剂型固定在棉塞体的远端。
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公开(公告)号：US06572874B1
公开(公告)日：2003-06-03
申请号：US09626025
申请日：2000-07-27
IPC分类号： A61F606
CPC分类号： A61K9/0036 , A61F6/08 , A61K9/0034 , A61K9/02
摘要： Devices, methods, and compositions for vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the vagina using a medicated intravaginal device comprising a bisphosphonate composition formulated for transvaginal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transvaginal delivery of bisphosphonates to the general circulation.
摘要翻译： 双膦酸盐阴道分泌物的装置，方法和组合物。 使用包含配制用于经阴道递送的二膦酸盐组合物的药物阴道装置将双膦酸盐靶向位点递送至阴道。 一种治疗骨质疏松症和相关骨骼和骨骼疾病的方法，用于通过阴道内给予双膦酸盐至阴道和经阴道分泌双膦酸盐至一般循环来预防骨质破坏和骨量丧失和强度。
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公开(公告)号：US6086909A
公开(公告)日：2000-07-11
申请号：US249963
申请日：1999-02-12
IPC分类号： A61M31/00 , A61F6/08 , A61F13/20 , A61K9/00 , A61K9/02 , A61K9/08 , A61K31/192 , A61K31/21 , A61K31/27 , A61K31/405 , A61K45/00 , A61P15/00 , A61F6/06 , A61F6/14 , A61F13/02
CPC分类号： A61K9/0034 , A61F6/08 , A61K9/0036
摘要： Methods, devices, and compositions for treatment of dysmenorrhea comprise an intravaginal drug delivery system containing an appropriate pharmaceutical agent incorporated into a pharmaceutically acceptable carrier whereby the pharmaceutical agent is released into the vagina and absorbed through the vaginal mucosa to provide relief of dysmenorrhea. The drug delivery system can be a tampon device, vaginal ring, pessary, tablet, suppository, vaginal medicated tampon, vaginal sponge, bioadhesive tablet, bioadhesive microparticle, cream, lotion, foam, ointment, paste, solution or gel. The system delivers a higher concentration to the muscle of the uterus, the primary site for the dyskinetic muscle contraction, which is the pathophysiologic cause of dysmenorrhea.
摘要翻译： 用于治疗痛经的方法，装置和组合物包括阴道内药物递送系统，其包含掺入药学上可接受的载体中的合适的药剂，由此将药剂释放到阴道中并通过阴道粘膜吸收以缓解痛经。 药物输送系统可以是棉塞装置，阴道环，子宫托，片剂，栓剂，阴道药物棉塞，阴道海绵，生物粘附片，生物粘附微粒，霜剂，洗剂，泡沫，软膏，糊剂，溶液或凝胶。 该系统向子宫肌肉提供更高的浓度，这是运动障碍肌肉收缩的主要部位，这是痛经的病理生理原因。
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公开(公告)号：US06197327B1
公开(公告)日：2001-03-06
申请号：US09079897
申请日：1998-05-15
IPC分类号： A61F606
CPC分类号： A61K9/0034 , A61F6/08 , A61K9/0036
摘要： Methods, devices, and compositions for treatment of dysmenorrhea comprise an intravaginal drug delivery system containing an appropriate pharmaceutical agent incorporated into a pharmaceutically acceptable carrier whereby the pharmaceutical agent is released into the vagina and absorbed through the vaginal mucosa to provide relief of dysmenorrhea. The drug delivery system can be a tampon device, vaginal ring, pessary, tablet, suppository, vaginal sponge, bioadhesive tablet, bioadhesive microparticle, cream, lotion, foam, ointment, paste, solution or gel. The system delivers a higher concentration to the muscle of the uterus, the primary site for the dyskinetic muscle contraction, which is the pathophysiologic cause of dysmenorrhea.
摘要翻译： 用于治疗痛经的方法，装置和组合物包括阴道内药物递送系统，其包含掺入药学上可接受的载体中的合适的药剂，由此将药剂释放到阴道中并通过阴道粘膜吸收以缓解痛经。 药物递送系统可以是棉塞装置，阴道环，子宫托，片剂，栓剂，阴道海绵，生物粘附片，生物粘附微粒，霜剂，洗剂，泡沫，软膏，糊剂，溶液或凝胶。 该系统向子宫肌肉提供更高的浓度，这是运动障碍肌肉收缩的主要部位，这是痛经的病理生理原因。
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5.发明授权公开(公告)号：US08178123B2
公开(公告)日：2012-05-15
申请号：US11522126
申请日：2006-09-15
IPC分类号： A61F2/02
CPC分类号： A61K36/61 , A61K9/0034 , A61K9/006 , A61K9/02 , A61K9/122 , A61K36/16 , A61K36/185 , A61K36/235 , A61K36/24 , A61K36/254 , A61K36/258 , A61K36/28 , A61K36/324 , A61K36/38 , A61K36/48 , A61K36/537 , A61K36/54 , A61K36/67 , A61K36/71 , A61K36/734 , A61K36/752 , A61K36/77 , A61K36/82 , A61K36/84 , A61K36/87 , A61K36/889 , A61K36/8962 , A61K36/906 , A61K36/9066 , A61K36/9068 , B33Y80/00 , A61K2300/00
摘要： A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.
摘要翻译： 对代谢细胞色素P-450酶和膜外排运输系统具有底物亲和力的治疗剂的阴道或口腔递送。 通过将所述药物通过阴道或颊粘膜递送至全身循环，增加对细胞色素P-450酶和膜外排转运体系具有底物亲和力的治疗剂的全身暴露的方法。
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6.发明授权Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections 失效真菌，细菌，病毒或寄生虫感染的阴道内或经阴道治疗的装置和方法公开(公告)号：US06416779B1
公开(公告)日：2002-07-09
申请号：US09613441
申请日：2000-07-11
IPC分类号： A61F608
CPC分类号： A61F6/08 , A61F13/2051 , A61K9/0034 , A61K9/0036
摘要： Devices, methods, and compositions for treating vaginal fungal, bacterial, viral and parasitic infections by intravaginal or transvaginal administration of therapeutic and/or palliative antifungal, antibacterial, antiviral or parasiticidal drugs to the vagina or to the uterus.
摘要翻译： 阴道内或阴道内施用治疗性和/或缓解性抗真菌剂，抗细菌剂，抗病毒药物或杀虫剂药物至阴道或子宫的治疗阴道真菌，细菌，病毒和寄生虫感染的装置，方法和组合物。
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公开(公告)号：US6053942A
公开(公告)日：2000-04-25
申请号：US135879
申请日：1998-08-18
申请人： Robert A. Eno , Donald C. Harrison , Jerry Griffin
发明人： Robert A. Eno , Donald C. Harrison , Jerry Griffin
CPC分类号： A61F2/2493 , A61F2/91
摘要： A transmyocardial implant includes a hollow rigid conduit having a first portion and a second portion. The first portion is sized to be larger than an initial lumen diameter of a coronary vessel. The first portion is smaller than an enlarged lumen diameter. The second portion is sized to extend from the first portion and through a myocardium into a heart chamber. The implant further includes a stent having a first stent diameter and adapted to be enlarged to an enlarged second stent diameter. In the first stent diameter, the stent is sized to be inserted into the initial lumen diameter. In the second diameter, the stent is sized to dilate the lumen to the enlarged lumen diameter. When the stent is at the second stent diameter, the stent has an internal diameter sized to receive the first portion of the conduit.
摘要翻译： 经心肌植入物包括具有第一部分和第二部分的中空刚性导管。 第一部分的尺寸被设计成大于冠状血管的初始管腔直径。 第一部分小于扩大的管腔直径。 第二部分的尺寸设计成从第一部分延伸并通过心肌进入心室。 植入物还包括具有第一支架直径并适于扩大到扩大的第二支架直径的支架。 在第一支架直径中，支架的尺寸设置成插入初始管腔直径。 在第二直径中，支架的尺寸被设计成将内腔扩张至扩大的管腔直径。 当支架处于第二支架直径时，支架具有尺寸设置成容纳导管的第一部分的内径。
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